DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CycD and Ccna1

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001292150.1	Gene:	Ccna1 / 12427	MGIID:	108042	Length:	421	Species:	Mus musculus

Alignment Length:	323	Identity:	89/323 - (27%)
Similarity:	141/323 - (43%)	Gaps:	52/323 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 PTSHCQRLDERLTTTADPPATDNVNTAIGDPTLYSDRCLENFLKVEEKHHKIPDTYFSIQKDITP 179
            ||:|.|          ...|||..:..| :.|.|::. :..:|:..|..|:....|...|.|||.
Mouse   145 PTTHAQ----------SEEATDFGSDVI-NVTEYAEE-IHRYLREAEVRHRPKAHYMRKQPDITE 197

  Fly   180 PMRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSSKSVRKTQLQILAAACLLLASKLRE--PS 242
            .||.|:.:|::||..|...:.|.:.||:|::|||||..||.:.:||::..|.:|||||..|  |.
Mouse   198 GMRAILVDWLVEVGEEYKLRTETLYLAVNFLDRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPP 262

  Fly   243 CRALSVDLLVVYTDNSIYKDDLIKWELYVLSRLGWDLSSVTPLDFLELLMMRLPIGSKNFPDINI 307
                .||..|..||::..|..|::.|..:|..|.:||:..|...||...:.|..:..:.   .|:
Mouse   263 ----DVDEFVYITDDTYTKRQLLRMEHLLLKVLAFDLTVPTTNQFLLQYLRRQGVCIRT---ENL 320

  Fly   308 GKVRGHAQAFISLAAKEHKFAKFSASTIAASSIAASMNGLKWHLRSGHNLHFLLSLMTDLTSVEQ 372
            .|.    .|.:||...: .|.|:..|.:||::...: |.:.       |.||....:...|....
Mouse   321 AKY----VAELSLLEAD-PFLKYLPSLVAAAAYCLA-NYIV-------NRHFWPETLAAFTGYSL 372

  Fly   373 AQVRDCM--LHMEDIFKEHSRNLEPFLVNIDPKEMSTLYYKRRFQIHQSQHLSQISIRPLPLP 433
            .::..|:  ||...:...|.           |::.....||....:|.|     :...|:.||
Mouse   373 NEIVPCLSELHKACLSIPHR-----------PQQAIREKYKASKYLHVS-----LMEPPVVLP 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	47/126 (37%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	23/111 (21%)
Ccna1	NP_001292150.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Cyclin_N2	27..>101	CDD:406812
		CYCLIN_CCNA1_rpt1	132..294	CDD:410263	56/164 (34%)
		CYCLIN_CCNA1_rpt2	298..420	CDD:410266	31/154 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840