DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CycD and CCNI

DIOPT Version :9

Sequence 1:	NP_523355.2	Gene:	CycD / 32551	FlyBaseID:	FBgn0010315	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_001335061.1	Gene:	CCNI / 10983	HGNCID:	1595	Length:	377	Species:	Homo sapiens

Alignment Length:	299	Identity:	68/299 - (22%)
Similarity:	124/299 - (41%)	Gaps:	64/299 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 LENFLKVEEKHHKIPDTYFSIQKDITPPMRKIVAEWMMEVCAEENCQEEVVLLALNYMDRFLSSK 217
            ||..:..|.:..|:........::::|..|..|.:|:.::..:.|...|...||.:.:||||::.
Human    16 LEKAITREAQMWKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATV 80

  Fly   218 SVRKTQLQILAAACLLLASKLREPSCRALSVDLLVVYTDNSI---YKDDLIKWELYVLSRLGWDL 279
            ......|..:|.:|..||:|..|...|   :.:|.|...:|.   ...::::.|..:|.:|.|||
Human    81 KAHPKYLSCIAISCFFLAAKTVEEDER---IPVLKVLARDSFCGCSSSEILRMERIILDKLNWDL 142

  Fly   280 SSVTPLDFLEL-----------LMMRLPIGSKNFPDINIG---KVRGHAQAFISLAAKEHKFAKF 330
            .:.||||||.:           |:..||   |..|..::.   |...|..|.       ::..:|
Human   143 HTATPLDFLHIFHAIAVSTRPQLLFSLP---KLSPSQHLAVLTKQLLHCMAC-------NQLLQF 197

  Fly   331 SASTIAASSIAASMNGL--KWHLRSGHNLHFLLSLMTDLTSVEQAQVRDC-MLHMEDIFKEHSRN 392
            ..|.:|.:.::..|..|  .|           |||..:|  :::||:... ::|..::...|...
Human   198 RGSMLALAMVSLEMEKLIPDW-----------LSLTIEL--LQKAQMDSSQLIHCRELVAHHLST 249

  Fly   393 LEPFLVNIDPKEMSTLYYKRR------------FQIHQS 419
            |:..|      .::::|..|.            |::|.|
Human   250 LQSSL------PLNSVYVYRPLKHTLVTCDKGVFRLHPS 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CycD	NP_523355.2	Cyclin_N	155..280	CDD:278560	30/127 (24%)
CycD	NP_523355.2	Cyclin_C	282..>392	CDD:281044	28/126 (22%)
CCNI	NP_001335061.1	Cyclin_N	34..142	CDD:365896	27/110 (25%)
CCNI	NP_001335061.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	357..377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146227
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840