Protein Alignment tay and auts2a

DIOPT Version :10

• Sequence 1: NP_573086.2
• Gene: tay / 32547
• FlyBaseID: FBgn0260938
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: XP_073770954.1
• Gene: auts2a / 368890
• ZFINID: ZDB-GENE-030616-571
• Length: 1276
• Species: Danio rerio
• Alignment Length: 1561
• Identity: 349/1561 - (22%)
• Similarity: 518/1561 - (33%)
• Gaps: 546/1561 - (34%)

  Fly  1112 SIKN---TNNGSNNGSANGQGQLSSVGLSSTSEIAKSNSVPTTSSPPNP--------------MV 1159
            |::|   .:||..|....|    |.:..||.||....::.|::||.|.|              ::
Zfish    17 SVRNRERISNGIRNNHVRG----SVLRFSSDSEKEDGSTNPSSSSRPRPPRRKRKESSSAEEDII 77

  Fly  1160 NGFLSVYPPPAATIATSSVTTSALSR---VSPNAANKLVPPVSATTSISINTNYVGISGGTTTTS 1221
            :||         :|| ..:|..||.:   :.|:...:               |..|
Zfish    78 DGF---------SIA-GFMTLEALEKDMTLKPHERRQ---------------NQAG--------- 108

  Fly  1222 GMGKVVFGAGGNAIVGTGSPL--LFPGAPPAPISHVATGVPMIIQAPPYRAPYTNYPLYTPYSGL 1284
                               ||  ..||       .||.|:.:.:
Zfish   109 -------------------PLRKKKPG-------RVANGLSLDL--------------------- 126

  Fly  1285 THGSYLPPVLPVATPNLSNLPPTQHRSSDSRNSRESPASLKSTPSNIGLNVSMAPTLRSITPLNN 1349
             |...|         |.||     |:.||..|:    ..|..|.|.......:....|.:.|..|
Zfish   127 -HKDRL---------NHSN-----HQHSDQENN----PRLARTHSKKKKKKHLQKKHRPLKPGQN 172

  Fly  1350 S-----SAISSGASQPVVSVVPSANSTALSMSNPHISHSHHVPAYASGAFSSSAAAGTSTPNSGL 1409
            :     |...||.|:|  |:..|:........:..........|.:...||::|   ...|:
Zfish   173 NCKDSDSESVSGESKP--SIRSSSRDRLTDCDSESDQEDKGSDASSEKLFSTAA---VKVPD--- 229

  Fly  1410 STLAVTSLSTSAAPQPHSHFPQSTQMLPQSGNFSSVSHLLTTHPMSSQNQPMVRCGSTLYSQSSA 1474
              .:|.:|||:|:.:...........|.:|...|..    |:..:||...|:|          ..
Zfish   230 --FSVDTLSTNASQELRGLGIPKVSGLERSQEKSQE----TSREISSATPPLV----------PT 278

  Fly  1475 AATAPPSAAAAVSNFTPSVLAVQSLTTAVTSSSSSPSTLSSSVIQKVISPKGESPCNKDRDSSYS 1539
            :...||         .|:.|.:|      ...||....|.|...|.      ::||.:
Zfish   279 SHPKPP---------LPAPLHLQ------PPPSSRGLPLPSRPAQT------QNPCPE------- 315

  Fly  1540 TNIRSHGASTMLPGASQGIGLGSSFCGIAP---SQYGGTGTPVLSSSSSMPPGLGNLSSYSSKAA 1601
            ..:|.......|| .|||..|..     ||   ||:     |..|.|...||         ...:
Zfish   316 RTLRPLSPPIALP-QSQGQELSQ-----APPHQSQH-----PPESPSHPKPP---------RTPS 360

  Fly  1602 LWLNSPANAVVTTCAPTTPIVSSGSARPTPPLSNCTSMGIG------MVNAASTARSSCNAISPL 1660
            ::.:.|:.|:.....||.|:      :..|| |.|....|.      .:|..|::|||.....|.
Zfish   361 IYHHPPSPALPAQQNPTQPV------QHRPP-SRCHQRPISAYSGSLTLNGLSSSRSSTPGKPPG 418

  Fly  1661 SIPATAGIHVSATNPSFQSSSYFPTPLAPPPSSPSPATSSAAIISSSASQFNPAVSHSMSSIVTT 1725
            ..|| ..:|.....|:..|:| ||.||:..|              :::..|.|::..|     |.
Zfish   419 PSPA-PHLHHHQPAPTGASAS-FPLPLSANP--------------TASHTFPPSLPSS-----TL 462

  Fly  1726 AGATTTTASSVTQPSVAAISNPVTNTPHPFSAESLFQP-----SKNDQADLLRRELDSRFL---- 1781
            ...|...||....|           .|.|.::.:|..|     |...:.|:||:||::|||
Zfish   463 PHHTNMFASPAALP-----------PPPPLTSNTLPVPGHPAGSAYSEQDILRQELNTRFLASQS 516

  Fly  1782 -DRSGLAVTPTPPSSTYLRTDL-----QHQ-QHAHLHQH---------PQLLPPVSAPSTPLSAV 1830
             || |.::.|.|    ||||:.     ||| ||.|.|||         |..:.|..||  |:...
Zfish   517 ADR-GASLGPPP----YLRTEFHQHQHQHQHQHQHTHQHTHQHTFTPFPHAIMPTPAP--PMVRT 574

  Fly  1831 QPSSGQIFPPPLFKDISKISSVDPQFYRTGM---------GLPP------------GGYSGYTSA 1874
            ...:.:.:|          :.||| |||..:         |:||            |.:...||.
Zfish   575 PARNFEKYP----------TKVDP-FYRHSLFHSYPPAVSGIPPVIPPTGPFGSLQGAFQPKTSN 628

  Fly  1875 GLLHSGLGGPTPF----MPPNHLTSFAP--KKTGRWNAMHVRIAWEIYYHQNKQSPEKQ------ 1927
            .|..:...|..|.    ..|.....|.|  :|.|:|.||||.|||:||:||.|...:.|
Zfish   629 PLDVAARPGAVPHTLLQKDPRLTDPFRPVLRKPGKWCAMHVHIAWQIYHHQQKVKQQMQVDPHKL 693

  Fly  1928 -----PGF---PTASSNAGSINAP---IPPGNMISGGGGGMASGASTPVNNVAAIPAVGGGVLVS 1981
                 |.|   |...:..|:|:.|   ..|.::.|      |:|::.|    ||.|        .
Zfish   694 DFGLKPEFLSRPPGPTLFGAIHHPHDLARPASLFS------AAGSTHP----AAAP--------F 740

  Fly  1982 NGPPSVLGMKTTPTLGMSSTPQHILHRASEMPPSAAFP--GGLPGRLAFETSPLAASFIGAPPSH 2044
            ..||              ..|.:.|..|..:.|.:..|  |||.     ..|..|...:|.|..
Zfish   741 GHPP--------------HHPSNFLTPAPHLEPFSRPPSFGGLA-----SLSTAAFGGLGNPAL- 785

  Fly  2045 IGTAVSPFGRYVTPFGFTGLTHFGGHLDSWRTNAMQRSVAYHPSSAAPSPNWPVKSDPGLDNARR 2109
              .:.|.||...:|   :...||.|..:.|  |.:.|:    |.|....|.| :|......:|..
Zfish   786 --ASNSVFGHKDSP---SAQQHFSGPHEPW--NRLHRT----PPSFPTPPPW-LKPGESERSASV 838

  Fly  2110 EAEERERELRDREQRERDRQRRERE-ERERKEKEEKLKREQQERE-------------------- 2153
            .:.||||| |||| ||||..:|:.. .::.||:|...||.|..:.
Zfish   839 SSHERERE-RDRE-RERDLDKRDSSVNKDDKEREPVEKRHQNHQSPLPVNPLTLLGHTRPSEPSR 901

  Fly  2154 --------RERERDR-KERERERREIERREMERER--------------MLQQQRINESNKQAAV 2195
                    |::::|: |:|||:|...:.::...:.              ::...|::|......:
Zfish   902 NHISSSEPRDKDKDKPKDRERDREHSDWKDSNTDEHKLKENHHSDKDTPVIHDGRVSEDKPANRI 966

  Fly  2196 QAA------------AAATAPVRDRSPHRNVGELNTEIRIKEEHPRTKEEQDVMLLRASAAAVGV 2248
            .|:            ...|..:.::.......:.|:|:::|||.   |||||
Zfish   967 TASPYMRPGGMDRVNGGLTRDILEKKAEITYEKKNSEVKVKEER---KEEQD------------- 1015

  Fly  2249 GDPRYHSSSLAAAQASAAAAAAHHHHANFMAASRHGLPPPPSHLTRTM----MPPTLSVG----- 2304
            |.........:..||....||.|                |||.:...|    |.|..|:.
Zfish  1016 GPTERSPEQRSTPQAPPPPAALH----------------PPSSMPVPMGMASMHPINSISSLERT 1064

  Fly  2305 ---GPITHFGAPAPPG----------WGIDPYRDPY---PILRYNPI-MEAALRHEAEERQKAIN 2352
               .|.  .|..|.||          |  ||.||||   .|.|.:|: .|..||::...|..|..
Zfish  1065 RMVAPF--MGISAIPGAERFPYPAFHW--DPMRDPYRGLDIHRRDPLARELLLRNDPLHRLAAPR 1125

  Fly  2353 IYAA---------------------------QSAAHLRSKEPSPIPPSVGSLGPPPPHHRLQIVS 2390
            :|.|                           |..|||..:|...:.......|...|.|...:..
Zfish  1126 LYEAERSYRDREPHDFNRDHPHVLTLEQRREQERAHLEERERLHLLREDYEQGRLHPMHHPVLDG 1190

  Fly  2391 SVAQSGVQQPGPPSQQQQQQMSSGG------GMVKNSGGPQAPGSIPVQHMISVDSMGQQSVSAK 2449
            .:...|:..||.||....:...|..      ..:.|...|.|..|.|..   .:.::|.:|.|.:
Zfish  1191 HLPHPGLMAPGLPSMHYPRVSPSSAVAAAAQNGILNKTPPTASLSAPPP---LIPTLGARSSSPR 1252

  Fly  2450 K 2450
            :
Zfish  1253 R 1253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tay	NP_573086.2	Auts2	1900..>2023	CDD:464656	39/141 (28%)
auts2a	XP_073770954.1	None