Protein Alignment tay and Auts2

DIOPT Version :10

• Sequence 1: NP_573086.2
• Gene: tay / 32547
• FlyBaseID: FBgn0260938
• Length: 2486
• Species: Drosophila melanogaster
• Sequence 2: NP_001350409.1
• Gene: Auts2 / 319974
• MGIID: 1919847
• Length: 1261
• Species: Mus musculus
• Alignment Length: 1591
• Identity: 344/1591 - (21%)
• Similarity: 492/1591 - (30%)
• Gaps: 654/1591 - (41%)

  Fly  1114 KNTNNGSNNGSANGQG----QLSSVGLSSTSEIAKSNSVPTTSSPPNP----------------M 1158
            :.:..|...|:|.|.|    :..|:..||.|: .:.|..|.:|:|..|                :
Mouse    24 RRSRAGLGTGAAGGIGAGRTRAPSLASSSGSD-KEDNGKPPSSAPSRPRPPRRKRRESTSAEEDI 87

  Fly  1159 VNGFLSVYPPPAATIATSSVTTSALSR---VSP-NAANKLVPPVSATTSISINTNYVGISGGTTT 1219
            ::||          ..||.||..||.:   |.| ..|.|...|::...
Mouse    88 IDGF----------AMTSFVTFEALEKDVAVKPQERAEKRQTPLTKKK----------------- 125

  Fly  1220 TSGMGKVVFGAGGNAIVGTGSPLLFPGAPPAPISHVATGVPMIIQAPPYRAPYTNYPLYTPYSGL 1284
                                                             |...||        ||
Mouse   126 -------------------------------------------------REALTN--------GL 133

  Fly  1285 THGSYLPPVLPVATPNLSNLPPTQHRSSDSRNSRESPASLKSTPSNIGLNVSMAPTLRSITPLNN 1349
            :..|           ..|.|..:.|.|||..|.|       :...::|....|...||.:.|..|
Mouse   134 SFHS-----------KKSRLSHSHHYSSDRENDR-------NLCQHLGKRKKMPKGLRQLKPGQN 180

  Fly  1350 S-----SAISSGASQPVVSVVPSANSTALSMSNPHISHSHHVPAYASGAFSSSAA---------- 1399
            |     |..:||.|:          ....|.|...:|.|....:..:|.|..|.:
Mouse   181 SCRDSDSESASGESK----------GFQRSSSRERLSDSSAPSSLGTGYFCDSDSDQEEKASDAS 235

  Fly  1400 ---------------------------AGTSTPN-SGLSTLAVTSLSTSAAP--------QPHSH 1428
                                       ||...|. |||......|......|        .||..
Mouse   236 SEKLFNTVLVNKDPELGVGALPEHNQDAGPIVPKISGLERSQEKSQDCCKEPVFEPVVLKDPHPQ 300

  Fly  1429 FPQSTQMLPQSGNFSSVSHLLTTHPMSSQNQPMVRC---GSTLYSQSSAAATAPPSAAAAVSNFT 1490
            .||.                    |..:|.:|.::.   |..|..::.|....||
Mouse   301 LPQL--------------------PSQAQAEPQLQIPSPGPDLVPRTEAPPQFPP---------- 335

  Fly  1491 PSVLAVQSLTTAVTSSSSSPSTLSSSVIQKVISPKGESPCNKDRDSSYSTNIRSHGASTMLPGAS 1555
            ||....|....|....:..|     .|.|:  .|:.:||              ||.....||...
Mouse   336 PSTQPAQGPPEAQLQPAPLP-----QVQQR--PPRPQSP--------------SHLLQQTLPPVQ 379

  Fly  1556 QGIGLGSSFCGIAPSQYGGTGTPVLSSSSSMPPGLGNLSSYSSKAALWLNSPANAVVTTCAPTTP 1620
            .           .||          |.|.|.|     ||:|:| ::|.|||      .:...:||
Mouse   380 S-----------HPS----------SQSLSQP-----LSAYNS-SSLSLNS------LSSRSSTP 411

  Fly  1621 IVSSGSARPTPP-LSNCTSMGIGMVNAASTARSSCNAISPLSIPATAGIHVSATNPSFQ--SSSY 1682
                ...:|.|| :|:..|        ||.        .|||:|..:.:|  :..|:.|  :.|:
Mouse   412 ----AKTQPAPPHISHHPS--------ASP--------FPLSLPNHSPLH--SFTPTLQPPAHSH 454

  Fly  1683 FPTPLAPPPSSPSPATSSAAIISSSASQFNPAVSHSMSSIVTTAGATTTTASSVTQPSVAAISNP 1747
            .|...|||.:.|.|                |.:                |:.|:..|.
Mouse   455 HPNMFAPPTALPPP----------------PPL----------------TSGSLQVPG------- 480

  Fly  1748 VTNTPHPFSAESLFQPSKNDQADLLRRELDSRFL-----DRSGLAVTPTPPSSTYLRTDL-QHQ- 1805
                 ||..       |...:.|:||:||::|||     || |.::.|.|    ||||:. |||
Mouse   481 -----HPAG-------STYSEQDILRQELNTRFLASQSADR-GASLGPPP----YLRTEFHQHQH 528

  Fly  1806 QHAHLHQH---------PQLLPPVSAPSTPLSAVQPSSGQIFPPPLFKDISKISSVDPQFYRTGM 1861
            ||.|.|||         |..:||.:...||            .||:|....  :.||| |||..:
Mouse   529 QHQHTHQHTHQHTFTPFPHAIPPTAIMPTP------------APPMFDKYP--TKVDP-FYRHSL 578

  Fly  1862 ---------GLPP------------GGYSGYTSAGLLHSGLGGPTPF----MPPNHLTSFAP--K 1899
                     |:||            |.:...||..:..:...|..|.    ..|.....|.|  :
Mouse   579 FHSYPPAVSGIPPMIPPTGPFGSLQGAFQPKTSNPIDVAARPGTVPHTLLQKDPRLTDPFRPMLR 643

  Fly  1900 KTGRWNAMHVRIAWEIYYHQNK------QSPEK-----QPGF---PTASSNAGSINAP---IPPG 1947
            |.|:|.||||.|||:||:||.|      ..|.|     :|.|   |...|..|:|:.|   ..|.
Mouse   644 KPGKWCAMHVHIAWQIYHHQQKVKKQMQSDPHKLDFGLKPEFLSRPPGPSLFGAIHHPHDLARPS 708

  Fly  1948 NMISGGGGGMASGASTPVN---------NVAA-------------IPAVGGGVLVSNG-----PP 1985
            .:.|..|....:|  ||..         |.||             :.||||......|     |.
Mouse   709 TLFSAAGAAHPTG--TPFGPPPHHSNFLNPAAHLEPFNRPSTFTGLAAVGGNAFGGLGNPSVTPN 771

  Fly  1986 SVLGMKTTPTLGMSSTPQHILHRASEMPPSAAFPGG--LPGRLAFETSPLAASF-----IGAPPS 2043
            ||.|.|.:|::...|.|....:|....|||...|..  .||.|  |.|..||:.     :....|
Mouse   772 SVFGHKDSPSVQNFSNPHEPWNRLHRTPPSFPTPPPWLKPGEL--ERSASAAAHDRDRDVDKRDS 834

  Fly  2044 HIGTAVSPFGRYVTPFGFTGLTHFGGHLDSWRTNAMQRSVAYHPSSAAPSPNWPV--------KS 2100
            .:...                       |..|.:..:|    |||..:|:|..||        .:
Mouse   835 SVSKD-----------------------DKERESVEKR----HPSHPSPAPPVPVSALGHNRSST 872

  Fly  2101 DPGLDNARREAEERERELRDREQRERDRQRREREERERKEKEEKLKREQQERERERERDRKERER 2165
            || ........|.||::....::|:....|::....|.|.||..|.          |||....|.
Mouse   873 DP-TTRGHLNTEAREKDKPKEKERDHSGSRKDLTTEEHKAKESHLP----------ERDGHSHEG 926

  Fly  2166 ERREIERREMERERM-------LQQQRINESNKQAAVQAAAAATAPVRDRSPHRNVGELNTEIRI 2223
            .....|.:::.|...       :...|.|.::.:.|        .|.:....:.| .:.|.|:::
Mouse   927 RAAGEEPKQLSRVPSPYVRTPGVDSTRPNSTSSREA--------EPRKGEPAYEN-PKKNAEVKV 982

  Fly  2224 KEEHPRTKEEQDVMLLRASAAAVGVGDPRYHSSSLAAAQASAAAAAAHHHHANFMAASRHGLPPP 2288
            |||.   ||:.|   |...|       |:.|.:|.|...:|:|:|:.|               |.
Mouse   983 KEER---KEDHD---LPTEA-------PQAHRTSEAPPPSSSASASVH---------------PG 1019

  Fly  2289 PSHLTRTMMPPTLSVGG--------------PITHFG--APAPPG---------WG--IDPYRDP 2326
            |    ...||.|:.|.|              .:|.|.  :|.|.|         |.  .||.|||
Mouse  1020 P----LASMPMTVGVTGIHAMNSIGSLDRTRMVTPFMGLSPIPGGERFPYPSFHWDPMRDPLRDP 1080

  Fly  2327 YPIL---RYNPI-MEAALRHEAEERQKAINIYAA------------------------------- 2356
            |..|   |.:|: .:..||::...|.....:|.|
Mouse  1081 YRDLDMHRRDPLGRDFLLRNDPLHRLSTPRLYEADRSFRDREPHDYSHHHHHHHHPLAVDPRREH 1145

  Fly  2357 QSAAHLRSKE------------------PSPIP-----PSVGSLGPPPPHHRLQIVSSVAQSGVQ 2398
            :...||..:|                  |:.:.     ||:.:.|.|..|:.....::..|:|:.
Mouse  1146 ERGGHLDERERLHVLREDYEHPRLHPVHPASLDGHLPHPSLLTPGLPSMHYPRISPTAGHQNGLL 1210

  Fly  2399 QPGPPSQQQQQQMSSGGGMVKNSGGPQAPGS 2429
            ...||:    ..:|:...::...||  .|||
Mouse  1211 NKTPPT----AALSAPPPLISTLGG--RPGS 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tay	NP_573086.2	Auts2	1900..>2023	CDD:464656	51/168 (30%)
Auts2	NP_001350409.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..88		14/64 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	105..236		37/232 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	251..486		77/391 (20%)
		Important for regulation of lamellipodia formation. /evidence=ECO:0000269|PubMed:25533347	288..471		64/304 (21%)
		PAT1	297..>490	CDD:401645	70/349 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	505..545		18/44 (41%)
		Auts2	644..848	CDD:464656	61/230 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	771..1023		73/332 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1148		0/26 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1201..1261		10/41 (24%)