DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tay and auts2b

DIOPT Version :9

Sequence 1:	NP_001259585.1	Gene:	tay / 32547	FlyBaseID:	FBgn0260938	Length:	2486	Species:	Drosophila melanogaster
Sequence 2:	XP_001921311.2	Gene:	auts2b / 100150849	ZFINID:	ZDB-GENE-131127-20	Length:	748	Species:	Danio rerio

Alignment Length:	757	Identity:	185/757 - (24%)
Similarity:	276/757 - (36%)	Gaps:	229/757 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly  1731 TTASSVTQPSVAAISNPVTNTPH--PFSAESLFQPSKNDQADLLRRELDSRFL-----DRSGLAV 1788
            |||.....|.:...:.||.:||.  |::           ..||||:||:||||     ||.|...
Zfish     5 TTALPPPPPLLTGSALPVPSTPSAGPYT-----------DHDLLRQELNSRFLASQTADRGGALA 58

  Fly  1789 TPTPPSSTYLRTDLQHQQHAHLHQHPQLLPP-----VSAPSTPLSAVQPSSGQIFPPPLFKDISK 1848
            .|     .||||:....||.|.|.|.....|     :.:|:.||  |:..:.|....|...|..:
Zfish    59 PP-----AYLRTEFHQHQHTHQHTHQHTFTPFPHSIMPSPAAPL--VRTPARQFEKYPAKVDSFQ 116

  Fly  1849 ISSVDPQFYRTGMGLPP-----GGYSGYTSAGLLHSGLGGPTPF------MPPNHLTSFA----- 1897
            ..|:.|.:.....|:||     |.:|  :..|........|...      :|..||...:
Zfish   117 RHSLVPSYPSVMTGIPPMVPPAGPFS--SLQGAFQPKASNPLDVVSRPGSVPHQHLQKDSRLLDP 179

  Fly  1898 ---PKKTGRWNAMHVRIAWEIYYHQNKQSPEKQ-----------PGFPTASSNAGSI-----NAP 1943
               |||.|:|.||||.|||::|:||.|...:.|           |.|...||.:..:     :.|
Zfish   180 MCKPKKPGKWCAMHVHIAWQVYHHQQKIKKQMQIEPHKLEFGFKPEFLNQSSGSNFVGLQPRDLP 244

  Fly  1944 IPPGNMISGGGGGMASGASTPVNNVAAIPAVGGGVLVSNGP--PSVL---GMKTTPT-LGMSSTP 2002
            .|                ||.::|.              ||  |||.   .::.||: |.....|
Zfish   245 RP----------------STILSNA--------------GPTHPSVSPYGSLQHTPSNLQSGLVP 279

  Fly  2003 QHILHRASEMPPSAAFPGGLPGRLAFETSPLAASFIGAPPSHIGT-AVSPFGRYVTPFGFTGLTH 2066
            .|      |....|...|||        :.|::|..|.    :|. :::|.....|..|....|.
Zfish   280 HH------ESLNKAVTFGGL--------TTLSSSAFGG----LGNPSLTPNAANGTKDGKMAATS 326

  Fly  2067 FGGHLDSWRTNAMQRSVAYHPSSAAPSPNWPVKSDPGLDNARREAEERERELRDREQRERD---- 2127
             .|.|:.|  |.:.::    |||....|..|..|:|          ||...:.||...:||
Zfish   327 -NGTLEPW--NRLHQT----PSSFPTPPLCPRPSEP----------ERAPSVPDRVANKRDSVDN 374

  Fly  2128 RQRREREER----------------ERKEKEEKLKR----EQQERERERER---------DRKER 2163
            :|.:||..:                |.|:..|.||.    |.:|.||.||:         :|:..
Zfish   375 KQDQERGLKDKSNVRQLSPVRNITLENKQSTESLKASTPDEHKEEERAREKPPAQELLHQNREIE 439

  Fly  2164 ERERREIERREMERERMLQQQRINESNKQAA------------------VQAAAAATAPVR-DRS 2209
            |::.:||...:.|::...:||:..| :|.||                  :|....|...:| :..
Zfish   440 EQKHKEIHSDKKEKDVKTEQQQPAE-DKPAAKESSSPKQREDLKRPNTDIQPWEPAEKKIRGEFE 503

  Fly  2210 PHRNVGELNTEIRIKEEHPRTKEEQDVM--LLRASAAAVGVGDPRYHSSSLAAAQASAAAAAAHH 2272
            ||..    .:::|:|||. |..::.||.  |........|...|..:.|||:.........|.|
Zfish   504 PHAK----TSKVRVKEER-RDDQDHDVTSHLKVLEKTWQGPRTPATNCSSLSTLPLPIGIPAGH- 562

  Fly  2273 HHANFMAASRHGLPPPPSHLTRTMMPPTLSVGG-PITHFGAPAPPGW--------GID-PYRDPY 2327
                            |......::.|.|.||. |:......:|..|        |:| |.||..
Zfish   563 ----------------PGLDRSRLVSPFLGVGPLPVAERLPYSPQHWESMRNVYRGLDLPRRDLL 611

  Fly  2328 P---ILRYNPIMEAALRHEAEERQKAINIYAAQSAAHLRSKE 2366
            .   ::|.:|:..|.:.|.|..|:..:...|.:...||..::
Zfish   612 GKDLLMRADPLQRAIIGHPAYPREPFLQSMALEQRNHLEERQ 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tay	NP_001259585.1	Auts2	1900..>1922	CDD:291981	13/21 (62%)
auts2b	XP_001921311.2	Auts2	185..393	CDD:291981	67/272 (25%)
auts2b	XP_001921311.2	CAF-1_p150	402..546	CDD:288454	36/149 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12098
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I4254
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.050