DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta13F and STE4

DIOPT Version :9

Sequence 1:	NP_001303567.1	Gene:	Gbeta13F / 32544	FlyBaseID:	FBgn0001105	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_014855.3	Gene:	STE4 / 854387	SGDID:	S000005738	Length:	423	Species:	Saccharomyces cerevisiae

Alignment Length:	386	Identity:	136/386 - (35%)
Similarity:	206/386 - (53%)	Gaps:	50/386 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NELDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPI--GRIQMRTRRTLRGHLAKIYAMHWG 64
            |::::.|||::.|...|..|:....|.||.|.|..:..:  .:|.::....|:||..||....|.
Yeast    37 NKIEAARQESKQLHAQINKAKHKIQDASLFQMANKVTSLTKNKINLKPNIVLKGHNNKISDFRWS 101

  Fly    65 NDSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNLKTR 129
            .||:.::||||||.:::|||.:..|.:||||.|.||::||.:||.:.||..||:|.|:||.: ::
Yeast   102 RDSKRILSASQDGFMLIWDSASGLKQNAIPLDSQWVLSCAISPSSTLVASAGLNNNCTIYRV-SK 165

  Fly   130 EGNV--RVSRELPGHGGYLSCCRFLDDNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSL 192
            |..|  .|:....||..|:|...|.|:..|:|:||||:|.||||....:|..:..|.|||:||::
Yeast   166 ENRVAQNVASIFKGHTCYISDIEFTDNAHILTASGDMTCALWDIPKAKRVREYSDHLGDVLALAI 230

  Fly   193 APQ------CKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCR 251
            ..:      ..||.|...|....:||.|.....|:|..::|||||:.||.:|.:...|||:....
Yeast   231 PEEPNSENSSNTFASCGSDGYTYIWDSRSPSAVQSFYVNDSDINALRFFKDGMSIVAGSDNGAIN 295

  Fly   252 LFDIRADQELAMYS-------------------------------------HDNIICGITSVAFS 279
            ::|:|:|..:|.:|                                     .||  .|:.|:.||
Yeast   296 MYDLRSDCSIATFSLFRGYEERTPTPTYMAANMEYNTAQSPQTLKSTSSSYLDN--QGVVSLDFS 358

  Fly   280 KSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGVTENGMAVATGSWDSFLRVWN 340
            .||||:.:.|.|..|.|||.:|.|..|.|.||..||:.:..:.:|:||.||||||.:::|:
Yeast   359 ASGRLMYSCYTDIGCVVWDVLKGEIVGKLEGHGGRVTGVRSSPDGLAVCTGSWDSTMKIWS 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta13F	NP_001303567.1	WD40	48..340	CDD:238121	122/336 (36%)
		WD40 repeat	58..95	CDD:293791	16/36 (44%)
		WD40 repeat	101..141	CDD:293791	15/41 (37%)
		WD40 repeat	146..181	CDD:293791	15/34 (44%)
		WD40 repeat	188..223	CDD:293791	10/40 (25%)
		WD40 repeat	229..265	CDD:293791	13/35 (37%)
		WD40 repeat	273..309	CDD:293791	16/35 (46%)
		WD40 repeat	315..339	CDD:293791	10/23 (43%)
STE4	NP_014855.3	WD40	87..419	CDD:238121	122/334 (37%)
		WD40 repeat	95..132	CDD:293791	16/36 (44%)
		WD40 repeat	138..179	CDD:293791	15/41 (37%)
		WD40 repeat	184..218	CDD:293791	15/33 (45%)
		WD40 repeat	226..266	CDD:293791	10/39 (26%)
		WD40 repeat	273..329	CDD:293791	14/55 (25%)
		WD40 repeat	352..388	CDD:293791	16/35 (46%)
		WD40 repeat	394..418	CDD:293791	10/23 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346074
Domainoid	1	1.000	47	1.000	Domainoid score	I3018
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I698
Isobase	1	0.950	-	0	Normalized mean entropy	S419
OMA	1	1.010	-	-		QHG54867
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		otm46827
orthoMCL	1	0.900	-	-		OOG6_101247
Panther	1	1.100	-	-	LDO	PTHR19850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R475
SonicParanoid	1	1.000	-	-		X182
TreeFam	0	0.000	Not matched by this tool.
	14	13.780