DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gbeta13F and Gnb5

DIOPT Version :9

Sequence 1:	NP_001303567.1	Gene:	Gbeta13F / 32544	FlyBaseID:	FBgn0001105	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_113958.1	Gene:	Gnb5 / 83579	RGDID:	620759	Length:	353	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	185/344 - (53%)
Similarity:	235/344 - (68%)	Gaps:	6/344 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NE-LDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPIGRIQMRTRRTLRGHLAKIYAMHWGN 65
            || |.||:.||||||..:.:.|....|..|.|.|..:|.:|:..|:|||||:||..|:..|.|..
  Rat     9 NETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCK 73

  Fly    66 DSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNL--KT 128
            |.|.:||:|||||:|||||.||||.||:.:..:|||.|||||||..:|||||||.||:|.|  ..
  Rat    74 DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 138

  Fly   129 REGNVRVSRELPGHGGYLSCCRFLD-DNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSL 192
            .|......:.:..|..|||.|.|.: |.||:|:|||.:|.|||:|:|..:.||.||..||:.|.|
  Rat   139 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 203

  Fly   193 APQ--CKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCRLFDI 255
            ||.  ..|||||.||..|.:||:|.|.|.|.|..||||:|:|.::|:|.|||:|||||||||:|:
  Rat   204 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDL 268

  Fly   256 RADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGV 320
            |||:|:|:||.::||.|.:||.||.|||||.|||:|:..||||.:|..|..||.||:||||.|.|
  Rat   269 RADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRV 333

  Fly   321 TENGMAVATGSWDSFLRVW 339
            :.:|.|..:||||..||||
  Rat   334 SPDGTAFCSGSWDHTLRVW 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta13F	NP_001303567.1	WD40	48..340	CDD:238121	165/297 (56%)
		WD40 repeat	58..95	CDD:293791	22/36 (61%)
		WD40 repeat	101..141	CDD:293791	20/41 (49%)
		WD40 repeat	146..181	CDD:293791	18/35 (51%)
		WD40 repeat	188..223	CDD:293791	18/36 (50%)
		WD40 repeat	229..265	CDD:293791	22/35 (63%)
		WD40 repeat	273..309	CDD:293791	20/35 (57%)
		WD40 repeat	315..339	CDD:293791	12/23 (52%)
Gnb5	NP_113958.1	WD40	56..353	CDD:238121	165/297 (56%)
		WD 1	61..100		23/38 (61%)
		WD40 repeat	66..103	CDD:293791	22/36 (61%)
		WD 2	103..142		22/38 (58%)
		WD40 repeat	109..151	CDD:293791	20/41 (49%)
		WD 3	151..192		20/40 (50%)
		WD40 repeat	156..192	CDD:293791	18/35 (51%)
		WD 4	194..236		21/41 (51%)
		WD40 repeat	199..236	CDD:293791	18/36 (50%)
		WD 5	237..276		25/38 (66%)
		WD40 repeat	242..278	CDD:293791	22/35 (63%)
		WD 6	278..320		23/41 (56%)
		WD40 repeat	286..322	CDD:293791	20/35 (57%)
		WD 7	323..352		16/28 (57%)
		WD40 repeat	328..352	CDD:293791	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820