DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta13F and gnb3b

DIOPT Version :9

Sequence 1:	NP_001303567.1	Gene:	Gbeta13F / 32544	FlyBaseID:	FBgn0001105	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_998367.1	Gene:	gnb3b / 406483	ZFINID:	ZDB-GENE-040426-2280	Length:	338	Species:	Danio rerio

Alignment Length:	340	Identity:	212/340 - (62%)
Similarity:	267/340 - (78%)	Gaps:	2/340 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNELDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPIGRIQMRTRRTLRGHLAKIYAMHWGN 65
            |.|::.:::|||.||..|..|||||.||.:..||..:.|..|:|::||:||:|||||||||||..
Zfish     1 MGEMEQMKKEAEGLKTQIEAARKAAHDTDMAAAAAGVAPAPRVQLKTRKTLKGHLAKIYAMHWCT 65

  Fly    66 DSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNLKTRE 130
            |:|.:|||||||||::||:|:.|||:|:||:|||||||:|||||:.||.|||||||::|||||..
Zfish    66 DNRLMVSASQDGKLLIWDAHSGNKVNAVPLKSSWVMTCSYAPSGNLVASGGLDNMCTVYNLKTPV 130

  Fly   131 GNVRVSRELPGHGGYLSCCRFLDDNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSLAPQ 195
              ::..:||..|.||||||||:.|.:|||||||.:|.|||:|||.|.|.||.|.||.|.|||:|.
Zfish   131 --IKTVKELDAHTGYLSCCRFISDTEIVTSSGDTTCALWDLETGKQKTVFLNHIGDCMCLSLSPD 193

  Fly   196 CKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCRLFDIRADQE 260
            ...|:|||||:.|||||||:|.|||||.||.|||||::|.|:..||.|||||.||:::|||||||
Zfish   194 NNMFISGACDSLAKLWDIRDGQCKQTFQGHTSDINAISFLPSATAFITGSDDCTCKMYDIRADQE 258

  Fly   261 LAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGVTENGM 325
            :..|....:..|:||||.|.||||:.|||||||||:||::|.|:.|:|:||||||||.||..:||
Zfish   259 VICYQDSALNSGVTSVALSVSGRLIFAGYDDFNCNIWDSLKGEKVGVLSGHDNRVSCTGVPGDGM 323

  Fly   326 AVATGSWDSFLRVWN 340
            .|.||||||||::||
Zfish   324 CVCTGSWDSFLKIWN 338

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta13F	NP_001303567.1	WD40	48..340	CDD:238121	189/291 (65%)
		WD40 repeat	58..95	CDD:293791	24/36 (67%)
		WD40 repeat	101..141	CDD:293791	24/39 (62%)
		WD40 repeat	146..181	CDD:293791	23/34 (68%)
		WD40 repeat	188..223	CDD:293791	23/34 (68%)
		WD40 repeat	229..265	CDD:293791	21/35 (60%)
		WD40 repeat	273..309	CDD:293791	23/35 (66%)
		WD40 repeat	315..339	CDD:293791	16/23 (70%)
gnb3b	NP_998367.1	WD40	<46..338	CDD:225201	190/293 (65%)
		WD40	48..338	CDD:238121	189/291 (65%)
		WD40 repeat	58..95	CDD:293791	24/36 (67%)
		WD40 repeat	101..139	CDD:293791	24/39 (62%)
		WD40 repeat	144..179	CDD:293791	23/34 (68%)
		WD40 repeat	186..221	CDD:293791	23/34 (68%)
		WD40 repeat	227..263	CDD:293791	21/35 (60%)
		WD40 repeat	271..307	CDD:293791	23/35 (66%)
		WD40 repeat	313..337	CDD:293791	16/23 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920