DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta13F and gpb-1

DIOPT Version :9

Sequence 1:	NP_001303567.1	Gene:	Gbeta13F / 32544	FlyBaseID:	FBgn0001105	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001366714.1	Gene:	gpb-1 / 174803	WormBaseID:	WBGene00001679	Length:	340	Species:	Caenorhabditis elegans

Alignment Length:	340	Identity:	292/340 - (85%)
Similarity:	320/340 - (94%)	Gaps:	0/340 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNELDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPIGRIQMRTRRTLRGHLAKIYAMHWGN 65
            |:|||.||||||.||:.||:|||:|.||:|...|::|||||||||||||||||||||||||||.:
Worm     1 MSELDQLRQEAEQLKSQIREARKSANDTTLATVASNLEPIGRIQMRTRRTLRGHLAKIYAMHWAS 65

  Fly    66 DSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNLKTRE 130
            |||||||||||||||||||:|||||||||||||||||||||||||:||||||||:||||:|||||
Worm    66 DSRNLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGSFVACGGLDNICSIYSLKTRE 130

  Fly   131 GNVRVSRELPGHGGYLSCCRFLDDNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSLAPQ 195
            ||||||||||||.|||||||||||||||||||||:|.|||||||.|.|:|.|||||||:|||:|.
Worm   131 GNVRVSRELPGHTGYLSCCRFLDDNQIVTSSGDMTCALWDIETGQQCTAFTGHTGDVMSLSLSPD 195

  Fly   196 CKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCRLFDIRADQE 260
            .:||:||||||||||||||:|:|||||||||||||||.|||:|.|||||||||||||||||||||
Worm   196 FRTFISGACDASAKLWDIRDGMCKQTFPGHESDINAVAFFPSGNAFATGSDDATCRLFDIRADQE 260

  Fly   261 LAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGVTENGM 325
            |||||||||||||||||||||||||.||||||||||||:|:.||:|:|||||||||||||||:||
Worm   261 LAMYSHDNIICGITSVAFSKSGRLLFAGYDDFNCNVWDSMRQERAGVLAGHDNRVSCLGVTEDGM 325

  Fly   326 AVATGSWDSFLRVWN 340
            ||.||||||||::||
Worm   326 AVCTGSWDSFLKIWN 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta13F	NP_001303567.1	WD40	48..340	CDD:238121	257/291 (88%)
		WD40 repeat	58..95	CDD:293791	33/36 (92%)
		WD40 repeat	101..141	CDD:293791	36/39 (92%)
		WD40 repeat	146..181	CDD:293791	29/34 (85%)
		WD40 repeat	188..223	CDD:293791	26/34 (76%)
		WD40 repeat	229..265	CDD:293791	32/35 (91%)
		WD40 repeat	273..309	CDD:293791	29/35 (83%)
		WD40 repeat	315..339	CDD:293791	20/23 (87%)
gpb-1	NP_001366714.1	WD40	48..340	CDD:238121	257/291 (88%)
		WD40 repeat	58..95	CDD:293791	33/36 (92%)
		WD40 repeat	101..141	CDD:293791	36/39 (92%)
		WD40 repeat	146..181	CDD:293791	29/34 (85%)
		WD40 repeat	188..223	CDD:293791	26/34 (76%)
		WD40 repeat	229..265	CDD:293791	32/35 (91%)
		WD40 repeat	273..309	CDD:293791	29/35 (83%)
		WD40 repeat	315..339	CDD:293791	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166301
Domainoid	1	1.000	106	1.000	Domainoid score	I4148
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55532
Inparanoid	1	1.050	620	1.000	Inparanoid score	I482
Isobase	1	0.950	-	0	Normalized mean entropy	S419
OMA	1	1.010	-	-		QHG54867
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		oto17828
orthoMCL	1	0.900	-	-		OOG6_101247
Panther	1	1.100	-	-	LDO	PTHR19850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R475
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890