DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta13F and Gnb5

DIOPT Version :9

Sequence 1:	NP_001303567.1	Gene:	Gbeta13F / 32544	FlyBaseID:	FBgn0001105	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_034443.1	Gene:	Gnb5 / 14697	MGIID:	101848	Length:	395	Species:	Mus musculus

Alignment Length:	344	Identity:	185/344 - (53%)
Similarity:	235/344 - (68%)	Gaps:	6/344 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 NE-LDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPIGRIQMRTRRTLRGHLAKIYAMHWGN 65
            || |.||:.||||||..:.:.|....|..|.|.|..:|.:|:..|:|||||:||..|:..|.|..
Mouse    51 NETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCK 115

  Fly    66 DSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNL--KT 128
            |.|.:||:|||||:|||||.||||.||:.:..:|||.|||||||..:|||||||.||:|.|  ..
Mouse   116 DKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDK 180

  Fly   129 REGNVRVSRELPGHGGYLSCCRFLD-DNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSL 192
            .|......:.:..|..|||.|.|.: |.||:|:|||.:|.|||:|:|..:.||.||..||:.|.|
Mouse   181 NENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDL 245

  Fly   193 APQ--CKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCRLFDI 255
            ||.  ..|||||.||..|.:||:|.|.|.|.|..||||:|:|.::|:|.|||:|||||||||:|:
Mouse   246 APSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDL 310

  Fly   256 RADQELAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGV 320
            |||:|:|:||.::||.|.:||.||.|||||.|||:|:..||||.:|..|..||.||:||||.|.|
Mouse   311 RADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRV 375

  Fly   321 TENGMAVATGSWDSFLRVW 339
            :.:|.|..:||||..||||
Mouse   376 SPDGTAFCSGSWDHTLRVW 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta13F	NP_001303567.1	WD40	48..340	CDD:238121	165/297 (56%)
		WD40 repeat	58..95	CDD:293791	22/36 (61%)
		WD40 repeat	101..141	CDD:293791	20/41 (49%)
		WD40 repeat	146..181	CDD:293791	18/35 (51%)
		WD40 repeat	188..223	CDD:293791	18/36 (50%)
		WD40 repeat	229..265	CDD:293791	22/35 (63%)
		WD40 repeat	273..309	CDD:293791	20/35 (57%)
		WD40 repeat	315..339	CDD:293791	12/23 (52%)
Gnb5	NP_034443.1	WD40	98..395	CDD:238121	165/297 (56%)
		WD 1	103..142		23/38 (61%)
		WD40 repeat	108..145	CDD:293791	22/36 (61%)
		WD 2	145..184		22/38 (58%)
		WD40 repeat	151..193	CDD:293791	20/41 (49%)
		WD 3	193..234		20/40 (50%)
		WD40 repeat	198..234	CDD:293791	18/35 (51%)
		WD 4	236..278		21/41 (51%)
		WD40 repeat	241..278	CDD:293791	18/36 (50%)
		WD 5	279..318		25/38 (66%)
		WD40 repeat	284..320	CDD:293791	22/35 (63%)
		WD 6	320..362		23/41 (56%)
		WD40 repeat	328..364	CDD:293791	20/35 (57%)
		WD 7	365..394		16/28 (57%)
		WD40 repeat	370..394	CDD:293791	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920