DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta13F and Gnb4

DIOPT Version :9

Sequence 1:	NP_001303567.1	Gene:	Gbeta13F / 32544	FlyBaseID:	FBgn0001105	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_001334991.1	Gene:	Gnb4 / 14696	MGIID:	104581	Length:	340	Species:	Mus musculus

Alignment Length:	340	Identity:	276/340 - (81%)
Similarity:	313/340 - (92%)	Gaps:	0/340 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNELDSLRQEAESLKNAIRDARKAACDTSLLQAATSLEPIGRIQMRTRRTLRGHLAKIYAMHWGN 65
            |:||:.||||||.|:|.|:|||||..|.:|:|..::::.:||||||||||||||||||||||||.
Mouse     1 MSELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGY 65

  Fly    66 DSRNLVSASQDGKLIVWDSHTTNKVHAIPLRSSWVMTCAYAPSGSYVACGGLDNMCSIYNLKTRE 130
            |||.|||||||||||:|||:||||:|||||||||||||||||||:|||||||||:||||||||||
Mouse    66 DSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE 130

  Fly   131 GNVRVSRELPGHGGYLSCCRFLDDNQIVTSSGDMSCGLWDIETGLQVTSFLGHTGDVMALSLAPQ 195
            ||||||||||||.|||||||||||.||:|||||.:|.|||||||.|.|:|.||:||||:|||:|.
Mouse   131 GNVRVSRELPGHTGYLSCCRFLDDGQIITSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPD 195

  Fly   196 CKTFVSGACDASAKLWDIREGVCKQTFPGHESDINAVTFFPNGQAFATGSDDATCRLFDIRADQE 260
            .|||||||||||:||||||:|:|:|:|.||.||||||:|||:|.|||||||||||||||:|||||
Mouse   196 LKTFVSGACDASSKLWDIRDGMCRQSFTGHISDINAVSFFPSGYAFATGSDDATCRLFDLRADQE 260

  Fly   261 LAMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTMKAERSGILAGHDNRVSCLGVTENGM 325
            |.:|||||||||||||||||||||||||||||||:|||.:|..|||:||||||||||||||::||
Mouse   261 LLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCSVWDALKGGRSGVLAGHDNRVSCLGVTDDGM 325

  Fly   326 AVATGSWDSFLRVWN 340
            ||||||||||||:||
Mouse   326 AVATGSWDSFLRIWN 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta13F	NP_001303567.1	WD40	48..340	CDD:238121	247/291 (85%)
		WD40 repeat	58..95	CDD:293791	31/36 (86%)
		WD40 repeat	101..141	CDD:293791	37/39 (95%)
		WD40 repeat	146..181	CDD:293791	26/34 (76%)
		WD40 repeat	188..223	CDD:293791	25/34 (74%)
		WD40 repeat	229..265	CDD:293791	29/35 (83%)
		WD40 repeat	273..309	CDD:293791	29/35 (83%)
		WD40 repeat	315..339	CDD:293791	21/23 (91%)
Gnb4	NP_001334991.1	WD40	48..340	CDD:238121	247/291 (85%)
		WD 1	53..92		33/38 (87%)
		WD40 repeat	58..95	CDD:293791	31/36 (86%)
		WD 2	95..134		36/38 (95%)
		WD40 repeat	101..141	CDD:293791	37/39 (95%)
		WD 3	141..179		29/37 (78%)
		WD40 repeat	146..181	CDD:293791	26/34 (76%)
		WD 4	182..221		29/38 (76%)
		WD40 repeat	188..223	CDD:293791	25/34 (74%)
		WD 5	224..263		33/38 (87%)
		WD40 repeat	229..265	CDD:293791	29/35 (83%)
		WD 6	268..307		33/38 (87%)
		WD40 repeat	273..309	CDD:293791	29/35 (83%)
		WD 7	310..339		26/28 (93%)
		WD40 repeat	315..339	CDD:293791	21/23 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849166
Domainoid	1	1.000	66	1.000	Domainoid score	I9873
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	609	1.000	Inparanoid score	I921
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54867
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		otm43518
orthoMCL	1	0.900	-	-		OOG6_101247
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R475
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.790