DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myb and DMTF1

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_001135799.1	Gene:	DMTF1 / 9988	HGNCID:	14603	Length:	760	Species:	Homo sapiens

Alignment Length:	645	Identity:	122/645 - (18%)
Similarity:	212/645 - (32%)	Gaps:	226/645 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TENGEEL-MNYGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPEL------------- 56
            :||.:.. :...:.::..:.|.:|...||:   ...||...|...||.:.|:
Human    79 SENDQSFEVTMTATTEVADDEVTEGTVTQI---QILQNEQLDEISPLGNEEVSAVSQAWFTTKED 140

  Fly    57 QDSKTTGQKGQNKSGKTSIGAVHPNYGFGKRWSKSE-DVL------------------------- 95
            :||.|      ||..|...|          .|||.| |:|
Human   141 KDSLT------NKGHKWKQG----------MWSKEEIDILMNNIERYLKARGIKDATEIIFEMSK 189

  Fly    96 ---------------------------------------------LKQLVETHGENWEIIGPHFK 115
                                                         ||:|...||.:|..||...
Human   190 DERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAAL- 253

  Fly   116 DRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKK----------WTLIARYLNGRI 170
            .|....|:.| .:::......|.||.:|:..:.::|......:          |..:|..:..|.
Human   254 GRSASSVKDR-CRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRS 317

  Fly   171 GKQCRERWHNHLN-PNIKKTAWTEKEDE---IIYQAHLELGNQ----WAKIAKRLPGRTDNAIKN 227
            .||||.:|.|:|| .....|.|| ||||   |:..|.|::.::    |..:|:
Human   318 EKQCRSKWLNYLNWKQSGGTEWT-KEDEINLILRIAELDVADENDINWDLLAE------------ 369

  Fly   228 HWNST-----MRRKYDVERRSVNASGSDLKSSRTHLITLIKSGGISKCMNNMQHN-----KESGG 282
            .|:|.     :|.|:...:|.: |:..|:.     ...|||  |:.:...|.::|     .:||.
Human   370 GWSSVRSPQWLRSKWWTIKRQI-ANHKDVS-----FPVLIK--GLKQLHENQKNNPTLLENKSGS 426

  Fly   283 EAVNKSENADGASV----------TAVKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPI 337
            ...|.:.|:....|          ||:....:|.     .|....:.|:|... ...|:..:| |
Human   427 GVPNSNTNSSVQHVQIRVARLEDNTAISSSPMAA-----LQIPVQITHVSSAD-SPATVDSET-I 484

  Fly   338 ILK----RTRKHIPETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFL---K 395
            .|.    :|.:.:|..|.|...:......|..::........:||.::...:.|.||...:   .
Human   485 TLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHAL 549

  Fly   396 SP--CLTTFEDMDLRASTP-----------VTKVYNRVGMEIKKEMETSSIETPHKSQLGPRTPT 447
            ||  .|.|.:::.::..||           :|...::..:.:..::::|..
Human   550 SPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDF-------------- 600

  Fly   448 PFKKALAAIGKKRDGRRYEPSSPSSLVED-LAEIIHEEHLSNSLTANNSKMMGAADQNST 506
                               |..|.:|..| ..:.||...::...:.|::.:...:|||||
Human   601 -------------------PEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNST 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	17/117 (15%)
		Myb_DNA-bind_6	88..147	CDD:290632	21/129 (16%)
		SANT	136..184	CDD:197842	16/58 (28%)
		Myb_DNA-bind_6	139..197	CDD:290632	20/68 (29%)
		SANT	188..235	CDD:197842	14/58 (24%)
		Myb_DNA-binding	188..233	CDD:278669	14/56 (25%)
		Cmyb_C	388..530	CDD:286408	22/136 (16%)
DMTF1	NP_001135799.1	Interaction with CCND2. /evidence=ECO:0000250	1..237		26/176 (15%)
		Required for DNA-binding. /evidence=ECO:0000250	87..458		82/412 (20%)
		Required for transcriptional activation. /evidence=ECO:0000250	87..170		23/101 (23%)
		SANT	<89..438	CDD:333364	79/390 (20%)
		Interaction with CCND1, CCND2 and CCND3. /evidence=ECO:0000250	176..760		97/529 (18%)
		Myb_DNA-bind_6	228..284	CDD:316443	15/57 (26%)
		Myb_DNA-binding	274..329	CDD:306708	14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	414..435		4/20 (20%)
		Required for transcriptional activation. /evidence=ECO:0000250	459..760		38/223 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..760
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930