DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Myb and CDC5L

DIOPT Version :9

Sequence 1:NP_511170.1 Gene:Myb / 32543 FlyBaseID:FBgn0002914 Length:657 Species:Drosophila melanogaster
Sequence 2:NP_001244.1 Gene:CDC5L / 988 HGNCID:1743 Length:802 Species:Homo sapiens


Alignment Length:667 Identity:132/667 - (19%)
Similarity:231/667 - (34%) Gaps:164/667 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    85 GKRWSKSEDVLLKQLVETHGEN-WEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVI 148
            |..|..:||.:||..|..:|:| |..|......:..:|.:.||.:.|:|.:.|..|:|:|::.::
Human     8 GGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLL 72

  Fly   149 KLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHL--------------------------NPNIK 187
            .|.: ..|.:|..||..: ||...||.|.:...|                          ||..|
Human    73 HLAK-LMPTQWRTIAPII-GRTAAQCLEHYEFLLDKAAQRDNEEETTDDPRKLKPGEIDPNPETK 135

  Fly   188 KTA-----WTEKEDEIIYQAHLELGNQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVERRSVNAS 247
            ...     ..|.|.|::.:|...|.|...|.|||      .|.:.......|.....:||.:.|:
Human   136 PARPDPIDMDEDELEMLSEARARLANTQGKKAKR------KAREKQLEEARRLAALQKRRELRAA 194

  Fly   248 GSDLKSSRTHLITLIKSGGI---------SKCMNNMQHNKESGGEAVN------KSENADGASVT 297
            |.:::..|.      :..|:         .|.........|...:|::      :.::.||...:
Human   195 GIEIQKKRK------RKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRS 253

  Fly   298 AVKGGDLAQESQD-DHQKGSNLAHLSMQ---------HLIKLTMPR--------QTPIILKRTRK 344
            ..:|.|..::.|. ..:|.|:|....:|         ...||.:|.        |..:.:.:..:
Human   254 EKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASE 318

  Fly   345 HIPETHHQAGC--SSSETFNQEEAAGN--ARSRPPSSP------------------VISPIKSLP 387
            ...:|..::|.  |:|.|...|....|  ...|.|.:|                  |.:|:|...
Human   319 IARQTAEESGITNSASSTLLSEYNVTNNSVALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGL 383

  Fly   388 FSPSHFLKSPCLTTFEDMDLRASTPVTKVYNRVGMEIKKEMETSSIETPHKSQLG--PR---TPT 447
            .:|.|           :.|....||..:|     ::....:.::...||.....|  ||   ||.
Human   384 NTPLH-----------ESDFSGVTPQRQV-----VQTPNTVLSTPFRTPSNGAEGLTPRSGTTPK 432

  Fly   448 PFKKALAAIGKKRDGRRYEPS------SPSSLVEDLA---------------------EIIHEEH 485
            |...:.......||.....|.      |..|.|:.:.                     ||:..|:
Human   433 PVINSTPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPEN 497

  Fly   486 LSNSL---TANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLSTWSSNHPYNAGSAKRIQPF 547
            ....|   ..:::.:..|||.::......:|:....|||..|::..........|   ...::|.
Human   498 AEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVN---ETILRPL 559

  Fly   548 ETETPSKFLTSPGDILKDTLCS--EQDL---PFD-EGRKENRPFHNRRINKYRGGLTY-DHVIDP 605
            ..|.|...|....:::|..:.:  ..||   |:: .|.|:.:.......|...  :|| :|....
Human   560 NVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKTVGFGTNNSEH--ITYLEHNPYE 622

  Fly   606 KWARVACGKSRDQMFME 622
            |:::....|::|.:..|
Human   623 KFSKEELKKAQDVLVQE 639

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MybNP_511170.1 SANT 85..132 CDD:197842 15/47 (32%)
Myb_DNA-bind_6 88..147 CDD:290632 19/59 (32%)
SANT 136..184 CDD:197842 15/73 (21%)
Myb_DNA-bind_6 139..197 CDD:290632 19/88 (22%)
SANT 188..235 CDD:197842 11/51 (22%)
Myb_DNA-binding 188..233 CDD:278669 11/49 (22%)
Cmyb_C 388..530 CDD:286408 32/176 (18%)
CDC5LNP_001244.1 REB1 6..>303 CDD:227476 67/308 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 108..143 3/34 (9%)
Nuclear localization signal. /evidence=ECO:0000255 165..271 20/117 (17%)
Required for interaction with CTNNBL1. /evidence=ECO:0000269|PubMed:21385873 200..206 1/11 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 247..278 8/30 (27%)
Interaction with PPP1R8. /evidence=ECO:0000269|PubMed:10827081 260..606 65/364 (18%)
Myb_Cef 404..655 CDD:403131 45/241 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..443 8/34 (24%)
Interaction with DAPK3. /evidence=ECO:0000250|UniProtKB:O08837 501..659 28/144 (19%)
Smc <626..802 CDD:224117 3/14 (21%)
Interaction with PLRG1. /evidence=ECO:0000269|PubMed:11544257 706..800
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5147
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.