DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and TTF1

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_031370.2	Gene:	TTF1 / 7270	HGNCID:	12397	Length:	905	Species:	Homo sapiens

Alignment Length:	612	Identity:	117/612 - (19%)
Similarity:	179/612 - (29%)	Gaps:	164/612 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASASTENGEELMNYGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPEL---QDSKTTG 63
            |||.....::.....||.:.|.....|............|.|....|...::|:|   ...|.:.
Human   212 ASAHKNKSKKKKKKSSNREYETLAMPEGSQAGREAGTDMQESQPTVGLDDETPQLLGPTHKKKSK 276

  Fly    64 QKGQNKSGKTSIGAVHPNYG------FGKRWSKSEDVLLKQLVETHGENWEIIGPHFKDRLEQQV 122
            :|.:.||......|:....|      .|....:|     :..|..|||...|..|.:|::.:::.
Human   277 KKKKKKSNHQEFEALAMPEGSQVGSEVGADMQES-----RPAVGLHGETAGIPAPAYKNKSKKKK 336

  Fly   123 Q----QRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLN 183
            :    |.:..|..||                          :|.:.|..|.
Human   337 KKSNHQEFEAVAMPE--------------------------SLESAYPEGS-------------- 361

  Fly   184 PNIKKTAWTEKEDEIIYQAHLELGNQWAKIAKRLPG-RTDNAIKNHWNSTMRRKYDVERRSVNAS 247
                             |...|:|......|  |.| :..|:.|.  .|..|:...|:|..|  |
Human   362 -----------------QVGSEVGTVEGSTA--LKGFKESNSTKK--KSKKRKLTSVKRARV--S 403

  Fly   248 GSDL----KSSRTHLITLIKSGG---------------ISKCMNNMQHNKESGGEAVNKSENADG 293
            |.|.    |:|.:.|...::..|               ...|:.:....:....|..|:..|.:.
Human   404 GDDFSVPSKNSESTLFDSVEGDGAMMEEGVKSRPRQKKTQACLASKHVQEAPRLEPANEEHNVET 468

  Fly   294 ASVTAVK--GGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIILKRTRKHIPETHHQAGCS 356
            |..:.::  ..|.......|...||.:..|  |..|.....|.|..|.:..|..:
Human   469 AEDSEIRYLSADSGDADDSDADLGSAVKQL--QEFIPNIKDRATSTIKRMYRDDL---------- 521

  Fly   357 SSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFLKSPCLTTFEDMDLRASTP--------V 413
              |.|.:.:|.|.|......|  :...|.|..:...||   .||..|..|....|.        :
Human   522 --ERFKEFKAQGVAIKFGKFS--VKENKQLEKNVEDFL---ALTGIESADKLLYTDRYPEEKSVI 579

  Fly   414 TKVYNRVGMEIKKEMETSSIETPHKSQLGPRTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLA 478
            |.:..|....:               .:|.....|:|.......|..|...|:........|.|
Human   580 TNLKRRYSFRL---------------HIGRNIARPWKLIYYRAKKMFDVNNYKGRYSEGDTEKL- 628

  Fly   479 EIIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLSTWSSNHPYNAGSA-- 541
                  .:.:||..|:.|.:|.....|:||..... |....:|.|    ..||.:.......|
Human   629 ------KMYHSLLGNDWKTIGEMVARSSLSVALKF-SQISSQRNR----GAWSKSETRKLIKAVE 682

  Fly   542 ----KRIQPFE-TETPSKFLTSPGDIL 563
                |::.|.| .|..||...:|...|
Human   683 EVILKKMSPQELKEVDSKLQENPESCL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	11/50 (22%)
		Myb_DNA-bind_6	88..147	CDD:290632	12/62 (19%)
		SANT	136..184	CDD:197842	3/47 (6%)
		Myb_DNA-bind_6	139..197	CDD:290632	3/57 (5%)
		SANT	188..235	CDD:197842	9/47 (19%)
		Myb_DNA-binding	188..233	CDD:278669	9/45 (20%)
		Cmyb_C	388..530	CDD:286408	28/149 (19%)
TTF1	NP_031370.2	N-terminal region (NRD). /evidence=ECO:0000250	1..223		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..443		54/298 (18%)
		Myb_DNA-bind_6	621..677	CDD:290632	15/67 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900