DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myb and Cdc5l

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_690023.1	Gene:	Cdc5l / 71702	MGIID:	1918952	Length:	802	Species:	Mus musculus

Alignment Length:	722	Identity:	140/722 - (19%)
Similarity:	248/722 - (34%)	Gaps:	188/722 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GKRWSKSEDVLLKQLVETHGEN-WEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVI 148
            |..|..:||.:||..|..:|:| |..|......:..:|.:.||.:.|:|.:.|..|:|:|::.::
Mouse     8 GGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLL 72

  Fly   149 KLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHL--------------------------NPNIK 187
            .|.: ..|.:|..||..: ||...||.|.:...|                          ||..|
Mouse    73 HLAK-LMPTQWRTIAPII-GRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETK 135

  Fly   188 KTA-----WTEKEDEIIYQAHLELGNQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVERRSVNAS 247
            ...     ..|.|.|::.:|...|.|...|.|||      .|.:.......|.....:||.:.|:
Mouse   136 PARPDPIDMDEDELEMLSEARARLANTQGKKAKR------KAREKQLEEARRLAALQKRRELRAA 194

  Fly   248 GSDLKSSRTHLITLIKSGGI---------SKCMNNMQHNKESGGEAVN------KSENADGASVT 297
            |.:::..|.      |..|:         .|.........|...:|::      :.::.||...:
Mouse   195 GIEIQKKRK------KKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRS 253

  Fly   298 AVKGGDLAQESQD-DHQKGSNLAHLSMQ---------HLIKLTMPR--------QTPIILKRTRK 344
            ..:|.|..::.|. ..:|.|:|....:|         ...||.:|.        |..:.:.:..:
Mouse   254 EKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASE 318

  Fly   345 HIPETHHQAG---CSSSETFNQEEAAGNARS-RPPSSP------------------VISPIKSLP 387
            ...:|..::|   .:||...::.....|:.: |.|.:|                  |.:|:|...
Mouse   319 VARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGL 383

  Fly   388 FSPSHFLKSPCLTTFEDMDLRASTPVTKVYNRVGMEIKKEMETSSIETPHKSQLG--PR---TPT 447
            .:|.|           :.|....||..:|     ::....:.::...||.....|  ||   ||.
Mouse   384 NTPLH-----------ESDFSGVTPQRQV-----VQTPNTVLSTPFRTPSNGAEGLTPRSGTTPK 432

  Fly   448 PFKKALAAIGKKRDGRRYEPS------SPSSLVEDLA---------------------EIIHEEH 485
            |...|.......||.....|.      |..|.|:.:.                     ||:..|:
Mouse   433 PVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPEN 497

  Fly   486 LSNSL---TANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLSTWSSNHPYNAGSAKRIQPF 547
            ....|   ..:::.:..|||.::......:|:....|||..|::..........|   ...::|.
Mouse   498 AEKELEEREIDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVN---ETILRPL 559

  Fly   548 ETETPSKFLTSPGDILKDTLCS--EQDL---PFD-EGRKENRPFHNRRINKYRGGLTY-DHVIDP 605
            ..|.|...|....:::|..:.:  ..||   |:: .|.|:.:.......|...  :|| :|....
Mouse   560 NVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEH--ITYLEHSPYE 622

  Fly   606 KWARVACGKSRDQMFME----------------------EQAYACLKNLSCISR--SLNFEKQKC 646
            |:::....|::|.:..|                      |:.|:.:..|...||  ..|...:|.
Mouse   623 KFSKEDLKKAQDALVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKD 687

  Fly   647 LVNSFDR 653
            .:.|.::
Mouse   688 RIESLEK 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	15/47 (32%)
		Myb_DNA-bind_6	88..147	CDD:290632	19/59 (32%)
		SANT	136..184	CDD:197842	15/73 (21%)
		Myb_DNA-bind_6	139..197	CDD:290632	19/88 (22%)
		SANT	188..235	CDD:197842	11/51 (22%)
		Myb_DNA-binding	188..233	CDD:278669	11/49 (22%)
		Cmyb_C	388..530	CDD:286408	33/176 (19%)
Cdc5l	NP_690023.1	SANT	8..56	CDD:197842	15/47 (32%)
		Myb_DNA-bind_6	11..71	CDD:290632	19/59 (32%)
		SANT_CDC5_II	56..106	CDD:212557	16/51 (31%)
		SANT	60..106	CDD:197842	15/47 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..143		3/34 (9%)
		Nuclear localization signal. /evidence=ECO:0000255	165..271		21/117 (18%)
		Required for interaction with CTNNBL1. /evidence=ECO:0000250\|UniProtKB:Q99459	200..206		2/11 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	246..278		8/31 (26%)
		Interaction with PPP1R8. /evidence=ECO:0000250\|UniProtKB:Q99459	260..606		64/364 (18%)
		Myb_Cef	404..655	CDD:288664	46/255 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..460		12/51 (24%)
		Interaction with DAPK3. /evidence=ECO:0000250\|UniProtKB:O08837	501..659		28/162 (17%)
		Interaction with PLRG1. /evidence=ECO:0000250\|UniProtKB:Q99459	706..800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900