DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and Myb

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_038954868.1	Gene:	Myb / 498982	RGDID:	1560020	Length:	747	Species:	Rattus norvegicus

Alignment Length:	826	Identity:	236/826 - (28%)
Similarity:	332/826 - (40%)	Gaps:	291/826 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVH 79
            |.|:.|        :||.::||.|      .|...|                  ||||..:|..
  Rat    10 YSSDED--------DEDIEMCDHD------YDGLLP------------------KSGKRHLGKT- 41

  Fly    80 PNYGFGKRWSKSEDVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDE 143
                   ||::.||..||:|||.:| ::|::|..:..:|.:.|.|.||.|||||||||||||::|
  Rat    42 -------RWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEE 99

  Fly   144 DDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGN 208
            |..||:||:.:|||:|::||::|.|||||||||||||||||.:|||:|||.||.||||||..|||
  Rat   100 DQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEDEDRIIYQAHKRLGN 164

  Fly   209 QWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVE---RRSVNASGSDLKSS---RTHLITLIKSG-- 265
            :||:|||.||||||||||||||||||||.:.|   :....||.:.:.||   ..||:....:.
  Rat   165 RWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVVSSFQKNNHLMGFAHASPP 229

  Fly   266 --------------GISKCMN-------------NMQHNKESGGEAVNKSEN-ADGASVTAVKGG 302
                          .|::..|             |:.:..:....|:.:..| .|......:|..
  Rat   230 PTSQSSVNGEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKRIKEL 294

  Fly   303 DLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIILKRTRKH--------IPETH--------- 350
            :|...|.::..||.. |..:..|.........|.|: .:||.|        :.|.|
  Rat   295 ELLLMSTENELKGQQ-ALPTQNHTCSYPGWHSTSIV-DQTRPHGDSAPVSCLGENHATPSLPADP 357

  Fly   351 ----------------HQ------------------------AGCS-SSETFNQEEAA------- 367
                            ||                        :.|. ||..|::|.||
  Rat   358 GSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSDSSRCDLSSFEFSEEAAAFSPSQQH 422

  Fly   368 -------------GNARSRPPS------------------SPVI--------------------- 380
                         |...:..||                  ||::
  Rat   423 TGKTFQLQEREGHGTRSAGEPSLRVTRRVLSEASLRQAKASPLVFLRKRRGQASPTAAGDSSSSL 487

  Fly   381 -----------SPIKSLPFSPSHFLKSPCLTTFEDMDLRASTPVTKVYNRVG---------MEIK 425
                       ||:||||||||.||.:.  :..|:..|  .||.......:|         ..:|
  Rat   488 FADVSSSTPKRSPVKSLPFSPSQFLNTS--SNHENSGL--DTPTLPSTPLIGHKLTPCHRDQTVK 548

  Fly   426 KEMETSSIETP--HKSQL--GPRTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLAEIIHEEHL 486
            .:.|.|...||  .:|.|  .||||||||.||||...|....:..|.:||.:||||.::|.:|
  Rat   549 TQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHVVEDLQDVIKQE-- 611

  Fly   487 SNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLST-------WSSNHPYNAGSAKRI 544
                           ...|.:..|::...||.:|:.::.:.|.       :.|||......:.::
  Rat   612 ---------------SDESGIVAEFHENGPPLLKKIKQEVDSPTEKAGNFFCSNHWEETNLSTQL 661

  Fly   545 QPFETETP---------SKFLTSPGDILKDTLCSEQDLPFDEGRKENRPFHNRRINKYRGGLTYD 600
              |...:|         |..|.:|....:|.:.....:|      :|||
  Rat   662 --FAQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVP------KNRP---------------- 702

  Fly   601 HVIDP------KWARV-ACGKSRDQMFMEEQAYACLKNLSCISRSL 639
             ::.|      .|... :|||:.|||....||...:...|  :|:|
  Rat   703 -LVGPLQPCVGAWEPTPSCGKTEDQMTASGQARKYVNTFS--ARTL 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	20/47 (43%)
		Myb_DNA-bind_6	88..147	CDD:290632	31/59 (53%)
		SANT	136..184	CDD:197842	33/47 (70%)
		Myb_DNA-bind_6	139..197	CDD:290632	39/57 (68%)
		SANT	188..235	CDD:197842	38/46 (83%)
		Myb_DNA-binding	188..233	CDD:278669	36/44 (82%)
		Cmyb_C	388..530	CDD:286408	46/161 (29%)
Myb	XP_038954868.1	SANT	40..88	CDD:197842	9/47 (19%)
		PLN03212	92..>197	CDD:178751	66/105 (63%)
		LMSTEN	265..309	CDD:400376	8/57 (14%)
		Cmyb_C	506..668	CDD:401307	30/152 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8542
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2621
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	1	1.000	-	-		FOG0000329
OrthoInspector	1	1.000	-	-		otm45598
orthoMCL	1	0.900	-	-		OOG6_100129
Panther	1	1.100	-	-	LDO	PTHR45614
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1086
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.970