DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and MYBL2

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_002457.1	Gene:	MYBL2 / 4605	HGNCID:	7548	Length:	700	Species:	Homo sapiens

Alignment Length:	778	Identity:	217/778 - (27%)
Similarity:	309/778 - (39%)	Gaps:	255/778 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVHPNYGFGKRWSKSEDVLL 96
            |:..|.|.....:.||    |.||.:|||..                       .:|:..||..|
Human     5 TRCEDLDELHYQDTDS----DVPEQRDSKCK-----------------------VKWTHEEDEQL 42

  Fly    97 KQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKKWT 160
            :.||...| ::|:.:..||.:|.:||.|.||.:||||:|:|||||::||..||:||:.:|.|:||
Human    43 RALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIELVKKYGTKQWT 107

  Fly   161 LIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGNQWAKIAKRLPGRTDNAI 225
            |||::|.||:||||||||||||||.:||:.|||:||.||.:||..|||:||:|||.||||||||:
Human   108 LIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAKMLPGRTDNAV 172

  Fly   226 KNHWNSTMRRKYDVERRSVNASGSDLKSSRTHLITLIKSGGISKC-----MNNMQHNKESGGEAV 285
            |||||||::||  |:.....:...|.|.....|:.|....|:...     ..::..|..|....:
Human   173 KNHWNSTIKRK--VDTGGFLSESKDCKPPVYLLLELEDKDGLQSAQPTEGQGSLLTNWPSVPPTI 235

  Fly   286 NKSENAD---------------GASVTAVK----------------------------------- 300
            .:.||::               |..:.||:
Human   236 KEEENSEEELAAATTSKEQEPIGTDLDAVRTPEPLEEFPKREDQEGSPPETSLPYKWVVEAANLL 300

  Fly   301 ----GG----------------------DLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIIL 339
                |.                      ||.:|...:....::|..|...|..::..|||...::
Human   301 IPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSAEDSINNSLVQLQASHQQQVLPPRQPSALV 365

  Fly   340 KRTRKHIPETHHQAGCSSSETFN------QEEAAGNARSRPPS------------SPVI------ 380
            ....::..:.|..:..|.|....      ..|..|:....|||            |||.
Human   366 PSVTEYRLDGHTISDLSRSSRGELIPISPSTEVGGSGIGTPPSVLKRQRKRRVALSPVTENSTSL 430

  Fly   381 -------------SPIKSLPFSPSHF-----------LKSPCLTTFEDMDLRASTPV-------- 413
                         :|:|:||||||.|           |:||.||         ||||
Human   431 SFLDSCNSLTPKSTPVKTLPFSPSQFLNFWNKQDTLELESPSLT---------STPVCSQKVVVT 486

  Fly   414 -------TKVYNRVGMEIKKEMETSSIETPHKSQLGPRTPTPFKKALAAIGKKRDGRRYEPSSP- 470
                   |.::.:....:..:.:.|...|||       ||||||.||         .:|.|..|
Human   487 TPLHRDKTPLHQKHAAFVTPDQKYSMDNTPH-------TPTPFKNAL---------EKYGPLKPL 535

  Fly   471 ---SSLVEDLAEIIHEEH-----LSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSL- 526
               ..|.|||.|::..|.     :.:.:.....|.....           .:||  :|:.||||
Human   536 PQTPHLEEDLKEVLRSEAGIELIIEDDIRPEKQKRKPGL-----------RRSP--IKKVRKSLA 587

  Fly   527 -----------LSTWSSNHPYNAGSAKRIQPFETETPSKFLTSPGDILKDTL--CSEQDLPFDEG 578
                       :||               .|.....|:   |:|.:....||  ..|.:...::|
Human   588 LDIVDEDVKLMMST---------------LPKSLSLPT---TAPSNSSSLTLSGIKEDNSLLNQG 634

  Fly   579 RKENRPFHNRRINKYRGGLTYDHVIDPKWARVACGKSRDQMFMEEQAYACLKNL--SCISRSL 639
            ..:.:|.......|.|...|....:...|..||||.:|||:||:|:|...|..|  |..||:|
Human   635 FLQAKPEKAAVAQKPRSHFTTPAPMSSAWKTVACGGTRDQLFMQEKARQLLGRLKPSHTSRTL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	18/47 (38%)
		Myb_DNA-bind_6	88..147	CDD:290632	28/59 (47%)
		SANT	136..184	CDD:197842	33/47 (70%)
		Myb_DNA-bind_6	139..197	CDD:290632	38/57 (67%)
		SANT	188..235	CDD:197842	33/46 (72%)
		Myb_DNA-binding	188..233	CDD:278669	32/44 (73%)
		Cmyb_C	388..530	CDD:286408	45/188 (24%)
MYBL2	NP_002457.1	SANT	31..79	CDD:197842	18/70 (26%)
		Myb_DNA-bind_6	34..94	CDD:290632	28/59 (47%)
		SANT	83..131	CDD:197842	33/47 (70%)
		Myb_DNA-binding	83..129	CDD:278669	31/45 (69%)
		SANT	135..182	CDD:197842	33/46 (72%)
		Myb_DNA-binding	135..178	CDD:278669	30/42 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..287		7/74 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..412		5/20 (25%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:8062924	411..417		0/5 (0%)
		Cmyb_C	451..594	CDD:286408	44/180 (24%)
		Bipartite nuclear localization signal	564..584		4/32 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11796
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	260	1.000	Inparanoid score	I3115
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	1	1.000	-	-		FOG0000329
OrthoInspector	1	1.000	-	-		otm41481
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1086
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.830