DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myb and Pbp95

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_649760.1	Gene:	Pbp95 / 40949	FlyBaseID:	FBgn0037540	Length:	721	Species:	Drosophila melanogaster

Alignment Length:	466	Identity:	96/466 - (20%)
Similarity:	179/466 - (38%)	Gaps:	85/466 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 RWSKSEDVLLKQLVETHGE----NWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMV 147
            |||:.::..|:.:|:.:..    ||:.:..:|.|:.:..:..|:..||:|.:...|:|..||.|:
  Fly   286 RWSEEDNDKLRAIVDRNTANSVINWKKVVEYFPDKSKSTLIGRYYYVLHPSISHEPFTTKEDMML 350

  Fly   148 IKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELG-NQWA 211
            ...|..:..|...........|...|.|.|:||.|....|..:|:.::|..:.....:.| :||.
  Fly   351 FAAVEEYNGKFHCFPRSLFPNRSLTQLRTRYHNVLAQRNKTDSWSVQDDTRLMSFVTQYGASQWL 415

  Fly   212 KIAKRLPGRTDNAIKNHWNSTMRRKYDVERR----SVNASGSDLKSSRTHLITLIKSGGISKCMN 272
            ..|        ..:.||..::.|.::.|.::    :.||...||...|:..::|:.|...::.:.
  Fly   416 NCA--------TFLGNHTRTSCRTRFLVIKKFLEQNPNAKVEDLPRRRSKKVSLVNSDNWAQRLQ 472

  Fly   273 NMQHNKESGGEAVNKSENADGASVTAVKGGDLAQESQDDHQKGSNLAHLSMQ--------HLIKL 329
            ..|.:.||   .||.:. ..|..|...|......|.|  .:..|.|:.:.::        :.:.|
  Fly   473 EWQEDPES---LVNDNP-PKGTRVRGPKSKKARIERQ--AESFSRLSKVDIEFCNFFKFSYNLTL 531

  Fly   330 TMPRQTPIILKRTRKHIPETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFL 394
            :.|:..|:                   ..:.:|..........:||..|  |.:::: |.|:..|
  Fly   532 STPKTFPV-------------------PKDVYNLAYVIRALAYKPPIRP--SLLQNI-FMPNDVL 574

  Fly   395 KSPCLTTF------EDMDLRASTPVTKVYNRVGM--------EIKKEMETSSIETPHKSQLGPRT 445
            |  |..:.      |:.|:::..........:|.        :.:|:.||.|.|  :...|.|
  Fly   575 K--CYNSMIRNLPDEEGDMKSPLLPPNWSTMMGFRALCILSGDCRKDTETRSFE--YNESLPP-- 633

  Fly   446 PTPFKKALAAIGKK-----RDGRRYEPSSPSSLV------EDLAEI-IHEEHLSNSLTANNSKMM 498
            ...|:|.|.|:..:     |...:.....||:||      .|.|:: .|.|.:.......|....
  Fly   634 IQLFRKRLQALFYRTTLLSRLESQLFTDLPSALVSLPRPKHDYAKMGTHVELIDPEPAPQNDLKS 698

  Fly   499 GAADQNSTLST 509
            ....:|..::|
  Fly   699 EPLSENEVINT 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	12/48 (25%)
		Myb_DNA-bind_6	88..147	CDD:290632	16/62 (26%)
		SANT	136..184	CDD:197842	14/47 (30%)
		Myb_DNA-bind_6	139..197	CDD:290632	15/57 (26%)
		SANT	188..235	CDD:197842	8/47 (17%)
		Myb_DNA-binding	188..233	CDD:278669	8/45 (18%)
		Cmyb_C	388..530	CDD:286408	31/148 (21%)
Pbp95	NP_649760.1	DUF883	4..>74	CDD:295076
		SANT	<194..240	CDD:304392
		SANT	229..276	CDD:197842
		Myb_DNA-binding	229..275	CDD:278669
		Myb_DNA-bind_6	287..350	CDD:290632	16/62 (26%)
		SANT	392..438	CDD:197842	10/53 (19%)
		Myb_DNA-binding	393..437	CDD:278669	10/51 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.930