DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and cdc5

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_593880.1	Gene:	cdc5 / 2543583	PomBaseID:	SPAC644.12	Length:	757	Species:	Schizosaccharomyces pombe

Alignment Length:	795	Identity:	145/795 - (18%)
Similarity:	250/795 - (31%)	Gaps:	314/795 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GKRWSKSEDVLLKQLVETHGEN-WEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVI 148
            |..|..:||.:||..|..:|:| |..|......:..:|.:.||.:.::|.:.|..|:|:||:.::
pombe     6 GGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDPSIKKTEWSREEDEKLL 70

  Fly   149 KLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLN------------------------------ 183
            .|.:.. |.:|..||..: ||...||.||:...|:
pombe    71 HLAKLL-PTQWRTIAPIV-GRTATQCLERYQKLLDDLEAKENEQLGLISGEGAEAAAPVNDPNSR 133

  Fly   184 -------PNIKKTA-------WTEKEDEIIYQAHLELGNQWAKIAKRLPGRTDNAIKNHWNSTMR 234
                   ||::...       ..|.|.|::.:|...|.|...|.||    |.|.  :.....|.|
pombe   134 LRFGEAEPNLETLPALPDAIDMDEDEKEMLSEARARLANTQGKKAK----RKDR--EKQLELTRR 192

  Fly   235 RKYDVERRSVNASGSDLKSSRTHLITL------------------------------------IK 263
            ..:..:||.:.|:|.::|..|.....:                                    |.
pombe   193 LSHLQKRRELKAAGINIKLFRRKKNEMDYNASIPFEKKPAIGFYDTSEEDRQNFREKREADQKII 257

  Fly   264 SGGISKCMNNMQH--------------------NKESGGEAVNKSENADGASV------------ 296
            ..||..  |.|:.                    ||::..|.:.:...|:..|.
pombe   258 ENGIRN--NEMESEGRKFGHFEKPKPIDRVKKPNKDAQEEKMRRLAEAEQMSKRRKLNLPSPTVS 320

  Fly   297 -----TAVK---GGDLAQESQD---DHQKGSNLAHLSMQHLIKLTMPRQTPI----------ILK 340
                 ..||   .||.|:...|   |....:||  |.....|:...|.:|||          :..
pombe   321 QDELDKVVKLGFAGDRARAMTDTTPDANYSTNL--LGKYTQIERATPLRTPISGELEGREDSVTI 383

  Fly   341 RTRKHIPETHHQAGCSSSETF-------------NQEEAAGNARSRPPSSPVISP---------- 382
            ..|..:.....|:.....|:.             ....|.|:|.:.|.::|..:|
pombe   384 EVRNQLMRNREQSSLLGQESIPLQPGGTGYTGVTPSHAANGSALAAPQATPFRTPRDTFSINAAA 448

  Fly   383 ----------------------IKSLPFSPSHF-LKSPCLTTFEDMDLRASTPV---------TK 415
                                  :..||...:.: |..|...  ::.|:.|:..|         .:
pombe   449 ERAGRLASERENKIRLKALRELLAKLPKPKNDYELMEPRFA--DETDVEATVGVLEEDATDRERR 511

  Fly   416 VYNRVGME-----------IKKEMETSSIETPHKSQLGPRTPTPFKKALAAIGKKRDGRRYEPSS 469
            :..|:..:           |::::...|:..|.|          :|::|            |...
pombe   512 IQERIAEKERLAKARRSQVIQRDLIRPSVTQPEK----------WKRSL------------ENED 554

  Fly   470 PSS--LVEDLAEIIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRAR--------- 523
            |::  |::::..:|..:.::...  .|||:.|.|::...||.|       .::|.|
pombe   555 PTANVLLKEMIALISSDAINYPF--GNSKVKGTANKVPDLSNE-------EIERCRLLLKKEIGQ 610

  Fly   524 ----------KSLLSTWSSNHPYNAGSAKRIQP---------FETETPSKFLTS--PGDILKDTL 567
                      |..|.|:|:.|  |..|   :.|         .:.|...||.|:  ..|:.|..|
pombe   611 LESDDYIQFEKEFLETYSALH--NTSS---LLPGLVIYEEDDEDVEAAEKFYTNDIQRDLAKKAL 670

  Fly   568 -CSE-QDLPFDEGRK--ENRPFHNRRINKYRGGLTYDHVIDPKWARVACGKSRDQMFMEEQAYAC 628
             |:: ::..:|..|.  |.|.|..::|:         |.    |..:...:
pombe   671 ECNKLENRVYDLVRSSYEQRNFLIKKIS---------HA----WKALQTER-------------- 708

  Fly   629 LKNLSCISRSLNFEK 643
             |||:|.....|.|:
pombe   709 -KNLTCYEFLYNQER 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	14/47 (30%)
		Myb_DNA-bind_6	88..147	CDD:290632	19/59 (32%)
		SANT	136..184	CDD:197842	17/84 (20%)
		Myb_DNA-bind_6	139..197	CDD:290632	20/101 (20%)
		SANT	188..235	CDD:197842	12/53 (23%)
		Myb_DNA-binding	188..233	CDD:278669	11/51 (22%)
		Cmyb_C	388..530	CDD:286408	28/183 (15%)
cdc5	NP_593880.1	REB1	1..535	CDD:227476	96/542 (18%)
		Myb_DNA-bind_6	9..69	CDD:290632	19/59 (32%)
		SANT_CDC5_II	54..103	CDD:212557	17/50 (34%)
		Myb_Cef	417..611	CDD:288664	34/226 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900