DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Myb and Dmtf1

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_035936.3	Gene:	Dmtf1 / 23857	MGIID:	1344415	Length:	761	Species:	Mus musculus

Alignment Length:	668	Identity:	130/668 - (19%)
Similarity:	217/668 - (32%)	Gaps:	235/668 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TENGEEL-MNYGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPEL------------- 56
            :||.:.. :...:.::..:.|.||...||:   ...||...|...||.:.|:
Mouse    79 SENDQSFEVTMTATTEVADDELSEGTVTQI---QILQNDQLDEISPLGTEEVSAVSQAWFTTKED 140

  Fly    57 QDSKTTGQKGQNKSGKTSIGAVHPNYGFGKRWSKSE-DVL------------------------- 95
            :||.|      ||..|...|          .|||.| |:|
Mouse   141 KDSLT------NKGHKWKQG----------MWSKEEIDILMNNIERYLKARGIKDATEIIFEMSK 189

  Fly    96 ---------------------------------------------LKQLVETHGENWEIIGPHFK 115
                                                         ||:|...||.:|..||...
Mouse   190 DERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAAL- 253

  Fly   116 DRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKK----------WTLIARYLNGRI 170
            .|....|:.| .:::......|.||.:|:..:.::|......:          |..:|..:..|.
Mouse   254 GRSASSVKDR-CRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRS 317

  Fly   171 GKQCRERWHNHLN-PNIKKTAWTEKEDE---IIYQAHLELGNQ----WAKIAKRLPGRTDNAIKN 227
            .||||.:|.|:|| .....|.|| ||||   |:..|.|::.::    |..:|:
Mouse   318 EKQCRSKWLNYLNWKQSGGTEWT-KEDEINLILRIAELDVADENDINWDLLAE------------ 369

  Fly   228 HWNST-----MRRKYDVERRSVNASGSDLKSSRTHLITLIKSGGISKCMNNMQHN-----KESGG 282
            .|:|.     :|.|:...:|.: |:..|:.     ...|||  |:.:...|.::|     .:||.
Mouse   370 GWSSVRSPQWLRSKWWTIKRQI-ANHKDVS-----FPVLIK--GLKQLHENQKNNPVLLENKSGS 426

  Fly   283 EAVNKSENADGASV----------TAVKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPI 337
            ...|.:.|:....|          ||:....:|.     .|....:.|:|.......::..:| |
Mouse   427 GVPNSNCNSSVQHVQIRVARLEDNTAISPSPMAA-----LQIPVQITHVSSTDSPAASVDSET-I 485

  Fly   338 ILK----RTRKHIPETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFL---K 395
            .|.    :|.:.:|..|.|...:......|..::........::|.::...:.|.||...:   .
Mouse   486 TLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTTNPTVTLAAAAPASPEQIIVHAL 550

  Fly   396 SP--CLTTFEDMDLRASTPVTKVYNRVGME-IKKEMETSSIETP--------HKSQLGPRTPTPF 449
            ||  .|.|.:::.::..||      ||.:: :..|..|||:...        |.|..
Mouse   551 SPEHLLNTSDNVTVQCHTP------RVIIQTVATEDITSSLSQEELTVDSDLHSSDF-------- 601

  Fly   450 KKALAAIGKKRDGRRYEPSSPSSLVED-LAEIIHEEHLSNSLTANNSKMMGAADQNST------- 506
                             |..|.:|..| ..:.|....::...:.||:.:...:|||||
Mouse   602 -----------------PEPPDALEADTFPDEIPRPKMTIQPSFNNAHVSKFSDQNSTELMNSVM 649

  Fly   507 -------LSTEYNAQSPP 517
                   ..|:...:.||
Mouse   650 VRTEEEIADTDLKQEEPP 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	17/117 (15%)
		Myb_DNA-bind_6	88..147	CDD:290632	21/129 (16%)
		SANT	136..184	CDD:197842	16/58 (28%)
		Myb_DNA-bind_6	139..197	CDD:290632	20/68 (29%)
		SANT	188..235	CDD:197842	14/58 (24%)
		Myb_DNA-binding	188..233	CDD:278669	14/56 (25%)
		Cmyb_C	388..530	CDD:286408	31/159 (19%)
Dmtf1	NP_035936.3	Interaction with CCND2	1..237		27/176 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..51
		Required for DNA-binding	87..458		83/412 (20%)
		Required for transcriptional activation	87..170		24/101 (24%)
		REB1	<122..378	CDD:227476	56/286 (20%)
		Interaction with CCND1, CCND2 and CCND3. /evidence=ECO:0000269\|PubMed:8887674	176..761		104/552 (19%)
		Myb_DNA-bind_6	228..284	CDD:372817	15/57 (26%)
		Myb_DNA-binding	274..329	CDD:365977	14/54 (26%)
		Required for transcriptional activation	459..761		45/246 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..625		8/65 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930