DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and Snapc4

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_011237366.1	Gene:	Snapc4 / 227644	MGIID:	2443935	Length:	1362	Species:	Mus musculus

Alignment Length:	809	Identity:	159/809 - (19%)
Similarity:	265/809 - (32%)	Gaps:	297/809 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NGEELMNYGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQ-----KGQ 67
            :.||:..:..:|:.......|....:|....:...::....:.|.:.||..|::..|     :..
Mouse   284 SAEEIRKFWQSSEHPSISKQEWSTEEVERLKAIAATHGHLEWHLVAEELGTSRSAFQCLQKFQQY 348

  Fly    68 NKSGKTSIGAVHPNYGFGKRWSKSEDVLLKQLVETHGENWEI-IGPH---------FKDRLEQQV 122
            ||:.|.            |.|::.||.:|.|||:      |: :|.|         .:.|...|:
Mouse   349 NKTLKR------------KEWTEEEDHMLTQLVQ------EMRVGNHIPYRKIVYFMEGRDSMQL 395

  Fly   123 QQRWAKVLNPELIKGPWTRDEDDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIK 187
            ..||.|.|:|.|.:|.|..:||..:::.|..:|.:.|..|...:.||...|||:|:...|:.::|
Mouse   396 IYRWTKSLDPSLKRGFWAPEEDAKLLQAVAKYGAQDWFKIREEVPGRSDAQCRDRYIRRLHFSLK 460

  Fly   188 KTAWTEKEDEIIYQAHLELG-NQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVERR--------- 242
            |..|..||::.:.|...:.| ..||:||..||.|:.:...:.|....|:|..::|:
Mouse   461 KGRWNAKEEQQLIQLIEKYGVGHWARIASELPHRSGSQCLSKWKILARKKQHLQRKRGQRPRHSS 525

  Fly   243 SVNASGSDLKSSRTHLITLIKSGGISKCMNNMQHNKESGGEAVNKSENAD---------GASVT- 297
            ..::|||...||.                   .:...||.:..:.|||:|         ..::|
Mouse   526 QWSSSGSSSSSSE-------------------DYGSSSGSDGSSGSENSDVELEASLEKSRALTP 571

  Fly   298 ---AVKGGDL-----------------------------AQESQDDHQKGSNLAHLSMQHLIKLT 330
               .|...||                             ...||:.|::||.....:.::  :|.
Mouse   572 QQYRVPDIDLWVPTRLITSQSQREGTGCYPQHPAVSCCTQDASQNHHKEGSTTVSAAEKN--QLQ 634

  Fly   331 MPRQTPIILKRTRK--HIPETHHQA----GCSSSETFNQEEAAGNARSRPP--SSPVISPIKSLP 387
            :|.:|...:.|..:  |..:||..:    .|........|:.....|:|||  |..::......|
Mouse   635 VPYETHSTVPRGDRFLHFSDTHSASLKDPACKPVLKVPLEKMPKLIRTRPPTQSHTLMKERPKQP 699

  Fly   388 FSPS-----------------------------------------HFLKSPCLTTFEDMDLR--- 408
            ..||                                         |.|....:....|::|.
Mouse   700 LLPSSRSGSDPGNNTAGPHLRQLWHGTYQNKQRRKRQALHRRLLKHRLLLAVIPWVGDINLACTQ 764

  Fly   409 ------------------------ASTPVTKV------YNRVG-MEIKKEM-------------- 428
                                    |||||..:      .:..| ||:.:|.
Mouse   765 APRRPATVQTKADSIRMQLECARLASTPVFTLLIQLLQIDTAGCMEVVRERKSQPPALLQPGTRN 829

  Fly   429 ------------------------ETSSIETPHKS--QLGP-RT-PTPFKKALAAIGKKRDGRRY 465
                                    |.::....||.  :||. || .|||:..:||    ..|.|.
Mouse   830 TQPHLLQASSNAKNNTGCLPSMTGEQTAKRASHKGRPRLGSCRTEATPFQVPVAA----PRGLRP 890

  Fly   466 EPSSPSSLVEDLAEIIHEEHLSNSLTA-----------------------NNSKMMGAADQNSTL 507
            :|.:.|.|:.:  :.:.|.|...:..|                       :.|.::|.|    |.
Mouse   891 KPKTVSELLRE--KRLRESHAKKATQALGLNSQLLVSSPVILQPPLLPVPHGSPVVGPA----TS 949

  Fly   508 STEYNAQSPPHMKRARKSLLSTWSSNHPYNAGSAKRIQPFETET--------------PSKFLT- 557
            |.|.:....|.|      :.|:.|.:.|....||...||...:|              |:.|.:
Mouse   950 SVELSVPVAPVM------VSSSPSGSWPVGGISATDKQPPNLQTISLNPPHKGTQVAAPAAFRSL 1008

  Fly   558 --SPGDI----------LKDTLCSEQDLP 574
              :||.:          ...|...:|.||
Mouse  1009 ALAPGQVPTGGHLSTLGQTSTTSQKQSLP 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	17/56 (30%)
		Myb_DNA-bind_6	88..147	CDD:290632	22/68 (32%)
		SANT	136..184	CDD:197842	15/47 (32%)
		Myb_DNA-bind_6	139..197	CDD:290632	19/57 (33%)
		SANT	188..235	CDD:197842	14/47 (30%)
		Myb_DNA-binding	188..233	CDD:278669	14/45 (31%)
		Cmyb_C	388..530	CDD:286408	44/281 (16%)
Snapc4	XP_011237366.1	REB1	<200..>407	CDD:227476	31/140 (22%)
		SANT	302..351	CDD:197842	8/48 (17%)
		Myb_DNA-bind_6	357..420	CDD:372817	22/68 (32%)
		Myb_DNA-bind_6	412..472	CDD:372817	19/59 (32%)
		SANT	461..504	CDD:197842	13/42 (31%)
		PHA03247	<815..1174	CDD:223021	44/239 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950