DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and Mybl2

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_006498936.1	Gene:	Mybl2 / 17865	MGIID:	101785	Length:	743	Species:	Mus musculus

Alignment Length:	773	Identity:	215/773 - (27%)
Similarity:	307/773 - (39%)	Gaps:	285/773 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 RWSKSEDVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIKL 150
            :|:..||..|:.||...| ::|:.:..||.:|.:||.|.||.:||||:|:|||||::||..||:|
Mouse    33 KWTHEEDEQLRALVRQFGQQDWKFLASHFPNRTDQQCQYRWLRVLNPDLVKGPWTKEEDQKVIEL 97

  Fly   151 VRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGNQWAKIAK 215
            |:.:|.|:|||||::|.||:||||||||||||||.:||:.|||:||.||.:||..|||:||:|||
Mouse    98 VKKYGTKQWTLIAKHLKGRLGKQCRERWHNHLNPEVKKSCWTEEEDRIICEAHKVLGNRWAEIAK 162

  Fly   216 RLPGRTDNAIKNHWNSTMRRKYD-----VERRS---------------------VNASGS----- 249
            .||||||||:|||||||::||.|     .|.|.                     |:..||
Mouse   163 MLPGRTDNAVKNHWNSTIKRKVDTGGFPAESRDCKPVYLLLELEDKEQHQGVQPVDGQGSLVSSW 227

  Fly   250 ---------------------------------------------DLK----------------- 252
                                                         .||
Mouse   228 PLVPSIVKEESSEEEIAIAATSAKELGHEPVPADLGEVRTPEPPESLKREYQEFSSPETSLPYKW 292

  Fly   253 -------------SSRTHLITLIKS--------------------GGISKCMNNMQHNKESGGEA 284
                         ||.:..:.||:|                    |.:.......|.:::...||
Mouse   293 VVEAANLLIPAVGSSLSEALDLIESDPDAWCDLSKFDLPEEPSTEGSVVSSPVQPQTSQQQQEEA 357

  Fly   285 VNKSENA--DGASVTAVKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQ--------TPIIL 339
            :..|:.|  .|.|||         |.:.|....|:|:..|...||.::...:        .|.:|
Mouse   358 LQSSQQAATPGPSVT---------EYRLDGHTISDLSRSSRGELIPISPSTEFGGSGIGTPPSVL 413

  Fly   340 KRTRKH----IPETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHF------- 393
            ||.:|.    .|.|.:.|..|..::.|         |..|.|   :|:|:||||||.|
Mouse   414 KRQKKRRVALSPVTENSASLSFLDSCN---------SLTPKS---TPVKTLPFSPSQFLNFWNKQ 466

  Fly   394 ----LKSPCLTTFEDMDLRASTPV---------------TKVYNRVGMEIKKEMETSSIETPH-- 437
                |:||.||         ||||               |.::.:....:.::::::.....|
Mouse   467 DTLELESPSLT---------STPVCSQKVVVTTPLHRDKTPLHQKYPSSVSQKLQSARAVVAHAF 522

  Fly   438 -----KSQLG--------------------------PRTPTPFKKALAAIGKKRDGRRYEPSSP- 470
                 :::.|                          |.||||||.||         .:|.|..|
Mouse   523 NPSTWEAEAGGFLSSRPAWSKESEVLPDQKYSMDNTPHTPTPFKNAL---------EKYGPLKPL 578

  Fly   471 ---SSLVEDLAEIIHEEH-----LSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLL 527
               ..|.|||.|::..|.     :.:.:.....|.....           .:||  :|:.||||.
Mouse   579 PQTPHLEEDLKEVLRSEAGMELIIEDDMRPEKQKRKPGL-----------RRSP--IKKVRKSLA 630

  Fly   528 --------STWSSNHPYNAGSAKRIQPFETETPSKF-LTSPGDILKDTLCSEQDLPFDEGRKENR 583
                    ...||..|      |.:....:.|||.. .||||.       .|.:...::|..:.:
Mouse   631 LDIMDEDGKLMSSTMP------KPLSLPTSVTPSSCGFTSPGS-------KEGNSLLNQGFLQAK 682

  Fly   584 PFHNRRINKYRGGLTYDHVIDPKWARVACGKSRDQMFMEEQAYACLKNL--SCISRSL 639
            |.......|.|..:.....:...|..||||.::||:||:|:|...|..|  |..||:|
Mouse   683 PEKVVAAQKTRSHIPTPAPMTHAWKTVACGGTKDQLFMQEKARQLLSRLKSSHTSRTL 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	18/45 (40%)
		Myb_DNA-bind_6	88..147	CDD:290632	28/59 (47%)
		SANT	136..184	CDD:197842	33/47 (70%)
		Myb_DNA-bind_6	139..197	CDD:290632	38/57 (67%)
		SANT	188..235	CDD:197842	33/46 (72%)
		Myb_DNA-binding	188..233	CDD:278669	32/44 (73%)
		Cmyb_C	388..530	CDD:286408	43/217 (20%)
Mybl2	XP_006498936.1	Myb_DNA-bind_6	34..94	CDD:372817	28/59 (47%)
		PLN03091	81..>219	CDD:215570	76/137 (55%)
		Cmyb_C	454..638	CDD:370427	43/214 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11849
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2683
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	1	1.000	-	-		FOG0000329
OrthoInspector	1	1.000	-	-		otm43530
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1086
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.830