Protein Alignment Myb and Myb

DIOPT Version :10

• Sequence 1: NP_511170.1
• Gene: Myb / 32543
• FlyBaseID: FBgn0002914
• Length: 657
• Species: Drosophila melanogaster
• Sequence 2: NP_001185843.1
• Gene: Myb / 17863
• MGIID: 97249
• Length: 755
• Species: Mus musculus
• Alignment Length: 812
• Identity: 238/812 - (29%)
• Similarity: 328/812 - (40%)
• Gaps: 293/812 - (36%)

  Fly    15 YGSNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVH 79
            |.|:.|        :||.::||.|      .|...|                  ||||..:|..
Mouse    10 YSSDED--------DEDIEMCDHD------YDGLLP------------------KSGKRHLGKT- 41

  Fly    80 PNYGFGKRWSKSEDVLLKQLVETHG-ENWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDE 143
                   ||::.||..||:|||.:| ::|::|..:..:|.:.|.|.||.|||||||||||||::|
Mouse    42 -------RWTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEE 99

  Fly   144 DDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGN 208
            |..||:||:.:|||:|::||::|.|||||||||||||||||.:|||:|||:||.||||||..|||
Mouse   100 DQRVIELVQKYGPKRWSVIAKHLKGRIGKQCRERWHNHLNPEVKKTSWTEEEDRIIYQAHKRLGN 164

  Fly   209 QWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVE---RRSVNASGSDLKSS---RTHLI-------- 259
            :||:|||.||||||||||||||||||||.:.|   :....||.:.:.:|   ..||:
Mouse   165 RWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQEGYLQEPSKASQTPVATSFQKNNHLMGFGHASPP 229

  Fly   260 -TLIKSG-----------GISKCMN-------------NMQHNKESGGEAVNKSEN-ADGASVTA 298
             .|..||           .|::..|             |:.:..:....|:.:..| .|......
Mouse   230 SQLSPSGQSSVNSEYPYYHIAEAQNISSHVPYPVALHVNIVNVPQPAAAAIQRHYNDEDPEKEKR 294

  Fly   299 VKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQTPIILKRTRKH------------------ 345
            :|..:|...|.::..||.. |..:..|.........|.|: .:||.|
Mouse   295 IKELELLLMSTENELKGQQ-ALPTQNHTCSYPGWHSTSIV-DQTRPHGDSAPVSCLGEHHATPSL 357

  Fly   346 ------IPETH---------HQ------------------------AGCS-SSETFNQEEAAGNA 370
                  :||..         ||                        :.|. ||..|::|.||.:.
Mouse   358 PADPGSLPEESASPARCMIVHQGTILDNVKNLLEFAETLQFIDSDSSWCDLSSFEFSEEAAAFSP 422

  Fly   371 RSRP------------------------------------PSSP--------------------- 378
            ..:|                                    |.||
Mouse   423 SQQPTGKAFQLQQREGHGTRSAGEPSLRVTRRVLSEASLGPDSPQARHSKVPLVVLRKRRGQASP 487

  Fly   379 -------------VI------SPIKSLPFSPSHFLKSPCLTTFEDMDLRA----STPVT--KVYN 418
                         ||      ||:||||||||.||.:.  :..|...|.|    |||:.  |:..
Mouse   488 LAAGEPSPSLFADVISSTLKRSPVKSLPFSPSQFLNTS--SNHESSGLDAPTLPSTPLIGHKLTP 550

  Fly   419 RVGMEIKKEMETSSIETP--HKSQL--GPRTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLAE 479
            .....:|.:.|.|...||  .:|.|  .||||||||.||||...|....:..|.:||..||||.:
Mouse   551 CRDQTVKTQKENSIFRTPAIKRSILESSPRTPTPFKHALAAQEIKYGPLKMLPQTPSHAVEDLQD 615

  Fly   480 IIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQSPPHMKRARKSLLST-------WSSNHPYN 537
            :|.:|                 ...|.:..|:....||.:|:.::.:.|.       :.|||  .
Mouse   616 VIKQE-----------------SDESGIVAEFQESGPPLLKKIKQEVESPTEKSGNFFCSNH--W 661

  Fly   538 AGSAKRIQPFETETP---------SKFLTSPGDILKDTLCSEQDLPFDEGRKENRPFHNRRINKY 593
            |.::...|.|...:|         |..|.:|....:|.:.....:|      :|||
Mouse   662 AENSLSTQLFSQASPVADAPNILTSSVLMTPVSEDEDNVLKAFTVP------KNRP--------- 711

  Fly   594 RGGLTYDHVIDP------KWARVACGKSRDQM 619
                    ::.|      .|...:|||:.|||
Mouse   712 --------LVGPLQPCSGAWEPASCGKTEDQM 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	Myb_DNA-bind_6	88..147	CDD:372817	31/59 (53%)
		PLN03212	136..>236	CDD:178751	75/99 (76%)
		Cmyb_C	388..>484	CDD:462753	41/105 (39%)
Myb	NP_001185843.1	SANT	40..88	CDD:197842	9/47 (19%)
		REB1	89..>191	CDD:227476	62/102 (61%)
		Interaction with HIPK2 and NLK. /evidence=ECO:0000269|PubMed:15082531	90..193		64/103 (62%)
		LMSTEN	268..313	CDD:462332	9/45 (20%)
		Transcriptional activation domain. /evidence=ECO:0000250	275..327		10/52 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	337..368		14/88 (16%)
		Leucine-zipper	375..396		13/26 (50%)
		Cmyb_C	516..671	CDD:462753	24/121 (20%)