DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and snpc-4

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	NP_492411.1	Gene:	snpc-4 / 172711	WormBaseID:	WBGene00001568	Length:	944	Species:	Caenorhabditis elegans

Alignment Length:	681	Identity:	132/681 - (19%)
Similarity:	248/681 - (36%)	Gaps:	167/681 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SNSDSEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVHPN 81
            ||.:.|:.:|.......|             .:|:.:..|..::|:.|..:..  ||.:..
Worm   254 SNEEVEKLKYLRESPKFV-------------SWPMLALNLGTNRTSYQCMEKY--KTEVSQ---- 299

  Fly    82 YGFGKRWSKSED---VLLKQLVETHGE-NWEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRD 142
              ..|.||:.||   :.|.::...:|. .|:.:......|..|||:.|::..|:..:..|.||..
Worm   300 --HSKEWSQDEDTKLIALTKITSINGHIQWDKVAQCMPGRTRQQVRTRFSHTLDASVKHGRWTDQ 362

  Fly   143 EDDMVIKLVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLN--PNIKKTAWTEKEDEIIYQAHLE 205
            ||.:::..|..:|.|.|..:|:.:..|...||||||.|.||  .::.:.....::::::|...:.
Worm   363 EDVLLVCAVSRYGAKDWAKVAQAVQNRNDSQCRERWTNVLNRSAHVNERFTLVEDEQLLYAVKVF 427

  Fly   206 LGNQWAKIAKRLPGRTDNAIKNHWNSTMRRKYDVERRSVNASGSDLKSSRTHLITLIKSGGISKC 270
            ....|||....||.:|...::..:...:..|..:.....||            :..:|||
Worm   428 GKGNWAKCQMLLPKKTSRQLRRRYLQLIAAKLRLAAGFCNA------------VDAMKSG----- 475

  Fly   271 MNNMQHNKESGGEAVNKSENADGASVTAVKGGDLAQESQDDHQKGSNLAHLSMQHLIKLTMPRQT 335
             .......|...|.:.::|......:..|. ...|.|:.|.::        :.:...|.....:.
Worm   476 -RRAPEEDELEQEDIVEAEQIPNELMKEVY-EKFANENPDMNE--------TPEEFYKRVSALER 530

  Fly   336 PIILK-RTRKHIPETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISPIKSLPFSPSHFLKSPCL 399
            |...: |..|:.|: :.:.....:|...:.:.|........||.::|.:
Worm   531 PAAARIRALKNKPD-YQKIQDKINEIVQKHKNAAEIDKELHSSEILSSL---------------- 578

  Fly   400 TTFEDMDLR----ASTPVTKVY---------NRVGMEIKKEMETSSIETPHKSQLGPRT-PTPFK 450
             |..::|:|    .|..:|:.|         :::|..::          |.|..|.|.| ||
Worm   579 -TITEVDVRYMIERSKTLTRYYEARQFRKNVDQIGCRVR----------PIKIDLDPETMPT--- 629

  Fly   451 KALAAIGKKRDGRRYEPSSPSSLVEDLAEIIHEEHLSNSLTANNSKMMGAADQNSTLSTEYNAQS 515
                          ::|:.    .||..:::..|.|.:.:.|::.|..|....|     |:...:
Worm   630 --------------FDPND----AEDEKQMVIVESLCSVIRAHDVKEWGTKFWN-----EHRFTA 671

  Fly   516 PPHMKRARKSL-------LSTWSSNHPYNAGSAKRIQPFETETPSKFLTSPG----DILK----- 564
            |.:.||..:::       ::.|     |...::|.....:...|:|....|.    |:.|
Worm   672 PKYAKRFVENMVINKSKEVAEW-----YLHVNSKSCNQNDVHCPAKSTLPPTAASFDLHKMLQKA 731

  Fly   565 ----DTLCSEQDLPFDEGRKENRPFHNRRINKYRGGLTYDHVIDPKWARVACGKSRDQMFMEEQA 625
                :.|.:|...|.|....:...|.|..    |.||..|.       |:..|.|.:....:|.|
Worm   732 RSGLNRLSAEHFYPLDVSLAQQFNFKNDE----REGLDGDR-------RMHIGLSDEVTNSKEYA 785

  Fly   626 --YACLKNLSC------ISRSLNFEKQKCLV 648
              ||.::::..      |:|..:.::.|.||
Worm   786 NFYARMRSILLEPMRLGIARESSSDETKRLV 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	14/50 (28%)
		Myb_DNA-bind_6	88..147	CDD:290632	18/62 (29%)
		SANT	136..184	CDD:197842	20/49 (41%)
		Myb_DNA-bind_6	139..197	CDD:290632	19/59 (32%)
		SANT	188..235	CDD:197842	7/46 (15%)
		Myb_DNA-binding	188..233	CDD:278669	7/44 (16%)
		Cmyb_C	388..530	CDD:286408	27/162 (17%)
snpc-4	NP_492411.1	SANT	<219..261	CDD:304392	3/6 (50%)
		SANT	250..298	CDD:197842	11/58 (19%)
		SANT	253..297	CDD:238096	11/57 (19%)
		SANT	302..346	CDD:197842	12/43 (28%)
		SANT	303..346	CDD:238096	11/42 (26%)
		Myb_DNA-binding	356..402	CDD:278669	18/45 (40%)
		SANT	357..404	CDD:197842	19/46 (41%)
		SANT	410..455	CDD:197842	7/44 (16%)
		SANT	411..455	CDD:238096	7/43 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100129
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2047
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930