DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myb and mybl2

DIOPT Version :9

Sequence 1:	NP_511170.1	Gene:	Myb / 32543	FlyBaseID:	FBgn0002914	Length:	657	Species:	Drosophila melanogaster
Sequence 2:	XP_002932915.2	Gene:	mybl2 / 100126220	XenbaseID:	XB-GENE-982419	Length:	746	Species:	Xenopus tropicalis

Alignment Length:	828	Identity:	230/828 - (27%)
Similarity:	327/828 - (39%)	Gaps:	295/828 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 SEESEYSENEDTQVCDKDSQQNSNADSGYPLDSPELQDSKTTGQKGQNKSGKTSIGAVHPNYGFG 85
            |..:...:.||.|..|.||            |.||.::|:..
Frog     2 SRRARGDDLEDLQYQDTDS------------DVPEPKESRVK----------------------- 31

  Fly    86 KRWSKSEDVLLKQLVETHGEN-WEIIGPHFKDRLEQQVQQRWAKVLNPELIKGPWTRDEDDMVIK 149
            .:|:..||..||.||:.||:: |::|..:..:|.|||.|.||.:||:|:|:|||||::||:.||:
Frog    32 VKWTPEEDETLKALVKKHGQSEWKVIASNLTNRTEQQCQHRWLRVLHPDLVKGPWTKEEDEKVIE 96

  Fly   150 LVRNFGPKKWTLIARYLNGRIGKQCRERWHNHLNPNIKKTAWTEKEDEIIYQAHLELGNQWAKIA 214
            ||:.:|.|.|||||:.|.||:||||||||||||||.:||::|||:||.||.|||..|||:||:||
Frog    97 LVKKYGTKHWTLIAKQLKGRMGKQCRERWHNHLNPEVKKSSWTEEEDRIICQAHKVLGNRWAEIA 161

  Fly   215 KRLPGRTDNAIKNHWNSTMRRKYD------VERRSVNA-----SGSDLKSSRTHLI--TLIKSGG 266
            |.||||||||:|||||||::||.:      :::.|.|.     ||......:..|:  |:..|..
Frog   162 KLLPGRTDNAVKNHWNSTIKRKVETGGFPTLKKGSGNQDEREDSGYQAAEEQQVLLSETVEMSAN 226

  Fly   267 IS---------KCMNNMQHNKESGGEAVNKSENADGASVT---------------------AVKG 301
            |:         |.:|..|..|   .|..::.|::...|||                     .|.|
Frog   227 IAEEQPNILSPKLLNKSQDIK---SEQESEGEDSTAESVTPSASALEDPGPEKWMVEYVNFLVPG 288

  Fly   302 GDLAQESQD-----------------------------------------DHQKGSNLAHLSMQH 325
            .|:.:...:                                         |....|:|...:...
Frog   289 SDIMESDPEAWCELSNFDLGEDSTVSDVGSPTRAVVADKPQTPNVTEYRLDGHTLSDLCKGNKGE 353

  Fly   326 LIKLTMPRQT-----PIILKRTRKHI---PETHHQAGCSSSETFNQEEAAGNARSRPPSSPVISP 382
            ||.::...|.     |.:||..::.|   |.|.:.|..::|.|        .|.|..|.|   :|
Frog   354 LIPISPQPQNAFGTPPSLLKHKKRKITLSPVTENGASITTSIT--------EANSMTPKS---TP 407

  Fly   383 IKSLPFSPSHF-----------LKSPCLTTFEDMDLRASTPVTKVYNRVGMEIKKE-----METS 431
            :||||||||.|           |::|.||         ||||......|...:.::     .:.|
Frog   408 VKSLPFSPSQFLNFWSRQDALELENPSLT---------STPVCSQKVVVTTPLHRDKTPLLQKNS 463

  Fly   432 SIETPHKSQLGP---RTPTPFKKALAAIGKKRDGRRYEPSSPSSLVEDLAEIIHEEHLSNSLTAN 493
            ...||:...:|.   .||||||.||...|..:.    .|.:| .|.|||.|::..|.....:..:
Frog   464 IFITPNHKFVGESVLHTPTPFKNALEKFGSLKP----LPQTP-HLEEDLKEVLRSESGIELIIVD 523

  Fly   494 NSKMMGAADQNSTLSTEYNAQSPPH--MKRARKSLLSTWSSNHP------YNAGSAKRIQP---- 546
            ..|:             ...:..||  :|:.||||........|      .::.::.|:||
Frog   524 EPKL-------------ERQKRKPHSPIKKVRKSLALDIIDKDPKPPSLTLSSAASTRMQPQTGD 575

  Fly   547 ------------------------------------------------------------FETET 551
                                                                        .||.|
Frog   576 SFLSVSLNESSCSSRGENSVLNQGFVQVKASKGAVAQLGETSQLATDIGELVKTQCGIGKTETHT 640

  Fly   552 PSKFLTSPGDILKDTLCSEQDLPFDEGRKENRPFHNRRINKYRGGLT-----------------Y 599
            |.|  |..|......||.:..:..|       .||:..|.....|..                 :
Frog   641 PLK--TEKGTFPDTDLCPQSLMDLD-------TFHSATITSNTHGANKAETRFQVKPDKAKIQKH 696

  Fly   600 DHVIDPK-----WARVACGKSRDQMFMEEQAYACLKNL---SCISRSL 639
            |.:..|:     |..||.|.|:||:.|:|:|.|.| ||   |..||:|
Frog   697 DVIKIPEPMTAAWKTVAFGGSQDQLLMQEKARAIL-NLYKHSPTSRAL 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myb	NP_511170.1	SANT	85..132	CDD:197842	20/47 (43%)
		Myb_DNA-bind_6	88..147	CDD:290632	29/59 (49%)
		SANT	136..184	CDD:197842	33/47 (70%)
		Myb_DNA-bind_6	139..197	CDD:290632	38/57 (67%)
		SANT	188..235	CDD:197842	34/46 (74%)
		Myb_DNA-binding	188..233	CDD:278669	33/44 (75%)
		Cmyb_C	388..530	CDD:286408	43/162 (27%)
mybl2	XP_002932915.2	Myb_DNA-bind_6	34..94	CDD:372817	29/59 (49%)
		PLN03091	81..>214	CDD:215570	77/132 (58%)
		Cmyb_C	413..567	CDD:370427	44/180 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	43	1.000	Domainoid score	I12196
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	308	1.000	Inparanoid score	I2580
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119160at33208
OrthoFinder	1	1.000	-	-		FOG0000329
OrthoInspector	1	1.000	-	-		otm48691
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1086
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.970