DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8578 and LRRFIP1

DIOPT Version :9

Sequence 1:	NP_001285302.1	Gene:	CG8578 / 32540	FlyBaseID:	FBgn0030699	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_001131024.1	Gene:	LRRFIP1 / 9208	HGNCID:	6702	Length:	808	Species:	Homo sapiens

Alignment Length:	490	Identity:	121/490 - (24%)
Similarity:	214/490 - (43%)	Gaps:	120/490 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AEDNALDQITKE----AEARLAARRQARAEAREIRMRELERQQKEQEITADRVFDMQNSTAVGSE 78
            |:...:|.::.|    |||||||:|.||||||||||:||||||||::.........:|::|
Human     7 AQSREIDCLSPEAQKLAEARLAAKRAARAEAREIRMKELERQQKEEDSERYSRRSRRNTSA---- 67

  Fly    79 TLSAHPVRLAYG------------------------GLLNVTRAS----ASRRSSED---SVEEE 112
              |....|::.|                        ||...|.||    :|||.|.|   |::.|
Human    68 --SDEDERMSVGSRGSLRVEERPEKDFTEKGSRNMPGLSAATLASLGGTSSRRGSGDTSISIDTE 130

  Fly   113 GRSFRDFK--HELKD----------------------VEERFRKAMITNAQLDNDRASQAYEVKL 153
            . |.|:.|  :||||                      |||:::|||::||||||::.:..|:|..
Human   131 A-SIREIKELNELKDQIQDVEGKYMQGLKEMKDSLAEVEEKYKKAMVSNAQLDNEKTNFMYQVDT 194

  Fly   154 LKDKCEIMEESYAQLQREFKEKMRDCNALKRNLDRANLELKLVQGQLNERDSLIAEQGLLIVA-- 216
            |||....:||..|:.:|:::||.::....|........:...|:..|.:|:.::.:.|:::.:
Human   195 LKDMLLELEEQLAESRRQYEEKNKEFEREKHAHSILQFQFAEVKEALKQREEMLEKHGIILNSEI 259

  Fly   217 VENADGSDAKRALVSVENAKV----LASVQGSLDVRLKKFS--DEKQRLLAEVQK---LHE-QLD 271
            ..|.:.||....:......|:    |.:::.:.|..|.:.|  :.|..::|.|.|   ||. :.:
Human   260 ATNGETSDTLNNVGYQGPTKMTKEELNALKSTGDGTLGRASEVEVKNEIVANVGKREILHNTEKE 324

  Fly   272 EYKSDGI----------SGRRSLSQGSFGD-------------ENDYEAQRETNKIISDHKYKLQ 313
            ::..|.:          :|..:..|.|..|             |...::|...:..:.::..:::
Human   325 QHTEDTVKDCVDIEVFPAGENTEDQKSSEDTAPFLGTLAGATYEEQVQSQILESSSLPENTVQVE 389

  Fly   314 KAE------------QEIANLQSSL-ARSETQVIRYKSTAEAAEK----AEAELKLERRKLQREH 361
            ..|            .|.:|..|.| ..:.|:.:...:..:..|:    |...|......:..:.
Human   390 SNEVMGAPDDRTRTPLEPSNCWSDLDGGNHTENVGEAAVTQVEEQAGTVASCPLGHSDDTVYHDD 454

  Fly   362 RELLEKLEEAETSNNHLLKRLDKLKNAKSAILKDL 396
            :.::|..:|.|||..|.|::  :..|.::|..|::
Human   455 KCMVEVPQELETSTGHSLEK--EFTNQEAAEPKEV 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8578	NP_001285302.1	DUF2051	47..321	CDD:286781	86/375 (23%)
LRRFIP1	NP_001131024.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..126		25/90 (28%)
		DUF2051	42..314	CDD:286781	72/278 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..415		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..808		9/29 (31%)
		DNA-binding	485..584		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155086
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2010
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434475at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41168
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR19212
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1677
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850