DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8578 and lrrfip1b

DIOPT Version :9

Sequence 1:	NP_001285302.1	Gene:	CG8578 / 32540	FlyBaseID:	FBgn0030699	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	XP_005168781.1	Gene:	lrrfip1b / 100321881	ZFINID:	ZDB-GENE-050208-324	Length:	598	Species:	Danio rerio

Alignment Length:	596	Identity:	176/596 - (29%)
Similarity:	260/596 - (43%)	Gaps:	215/596 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TGRRR--NNMRINAEDNALDQITKEAEARLAARRQARAEAREIRMRELERQQKE----------- 58
            |||:|  |..:::|||:||.||.:||||||||:|.||||||||||:||||||||
Zfish     6 TGRKRIPNREKLSAEDDALIQIAREAEARLAAKRAARAEAREIRMKELERQQKEIYHAQKKYYGL 70

  Fly    59 -------QEITAD------------RVFDMQNSTAVG-------------SETLSAHPVRLA--- 88
                   ::...|            .:.|.:...:||             |.|.|....||.
Zfish    71 DSKWGHIEQWMEDSERYSRHTRRHTSISDDEERMSVGSRGSLRGNHADLCSSTSSLTSARLQNGR 135

  Fly    89 ----------------------------------------YGGLLNVTRASASRRSS-------- 105
                                                    |.|.|..:..::||.||
Zfish   136 PSALFIETPRSRSHRGSLHEESSYSATRRFSGSSARGPSDYNGFLGSSSRASSRASSARASPVVE 200

  Fly   106 --EDSVEEEGR---------------------------------SFRDFKHELKDVEERFRKAMI 135
              .|.:|:..|                                 |.|:.|..|.:|||::||||:
Zfish   201 ERSDFLEKGSRTASTLSAATLASLGGGLSRRGSCDTSISADTEASIREMKDSLVEVEEKYRKAMV 265

  Fly   136 TNAQLDNDRASQAYEVKLLKDKCEIMEESYAQLQREFKEKMRDC-------NALKRNLDRANLEL 193
            :.|||||::.:..|:|..|:|....:||...:.|||.:||.|:|       |.||...:.....|
Zfish   266 SIAQLDNEKTNMMYQVDTLRDTLMELEELLCETQREREEKTRECERERHAHNVLKFQFEEMKETL 330

  Fly   194 K-----LVQGQL----------------------------------------NERDSL------- 206
            |     |.:.|.                                        :||::|
Zfish   331 KQSEELLTEAQQSRGKHADYIREISDLQETLEWKDKKILALERQKEYSDIIHDERETLRDEVCRL 395

  Fly   207 ---IAEQGLLIVAVENADGSDAKRAL---VSVENA----KVLASVQGSLDVRLKKFSDEKQRLLA 261
               :.:.|:::.:...|:|.....|:   |:.|.|    :.|:|....|::||:|..:|::.||.
Zfish   396 RDALKKNGIVMGSEVTANGKVEDGAIDRHVNAETASRLNQDLSSGDSMLEIRLRKLMEERESLLD 460

  Fly   262 EVQKLHEQLDEYKSDGISGRRSLSQGSFGDEND---------YEAQRETNKIISDHKYKLQKAEQ 317
            :|:||....::.:.:|..     ..|| .||:|         .:.||:.|:.|||.|:||.|:||
Zfish   461 QVRKLKASAEQKQKNGTE-----ETGS-ADEDDLQNGLDPHILDLQRDANRQISDLKFKLVKSEQ 519

  Fly   318 EIANLQSSLARSETQVIRYKSTAEAAEKAEAELKLERRKLQREHRELLEKLEEAETSNNHLLKRL 382
            |:..|:.::.|.|.||.|||::||||||.|.|||:|:||||||.|..|::::|.|.||:||.|||
Zfish   520 EVTALEQNIIRLEGQVSRYKTSAEAAEKVEDELKVEKRKLQRELRSALDRIDELEASNSHLTKRL 584

  Fly   383 DKLKNAKSAIL 393
            :|:|..:||:|
Zfish   585 EKMKANRSALL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8578	NP_001285302.1	DUF2051	47..321	CDD:286781	107/480 (22%)
lrrfip1b	XP_005168781.1	DUF2051	207..522	CDD:286781	79/320 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590148
Domainoid	1	1.000	84	1.000	Domainoid score	I8180
eggNOG	1	0.900	-	-		E1_KOG2010
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	265	1.000	Inparanoid score	I3038
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1434475at2759
OrthoFinder	1	1.000	-	-		FOG0002905
OrthoInspector	1	1.000	-	-		otm24620
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19212
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1677
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900