DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS and RARS1

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_002878.2	Gene:	RARS1 / 5917	HGNCID:	9870	Length:	660	Species:	Homo sapiens

Alignment Length:	670	Identity:	383/670 - (57%)
Similarity:	488/670 - (72%)	Gaps:	19/670 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSELNMELKKLRELELKTQGLAARIQTAKSGEQLDV--DLVQLQIENKKLKNRLFILKKSIAEES 63
            :||.:..|.: :|.|:|:  |.|.|...|:...|..  :|.|||.||.|||.||.||:||:..|.
Human     5 VSECSARLLQ-QEEEIKS--LTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAER 66

  Fly    64 TAAGGDVSKP-KESSSITEHLESVFRQAIASAFPEFRDTPVIIAPVNSTSAKFGDYQCNNAMGLS 127
                   :|| |...:|...|:.||..||.:|:|:..:.|:::.|  |..|||||||||:|||:|
Human    67 -------NKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTP--SQQAKFGDYQCNSAMGIS 122

  Fly   128 KKLKEKGINKAPRDIATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRNGVKPPE 192
            :.||.|.....||:||..:..|.|.:..|||:||||.||:||.|.||:.|..|::||.|||:.|.
Human   123 QMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPA 187

  Fly   193 V-IKKRVLVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLIAHL 256
            : ..|:|:||||||||||:||||||||||||||:.||.||..:||:|:||:||||||||||||||
Human   188 LGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHL 252

  Fly   257 EDRFPNYLNESPPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIKAWELICNVSRK 321
            :|:||:||..||||.|||:||||||||||.:||||||||..||.||...|:..|||:|||:|||:
Human   253 QDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQ 317

  Fly   322 EFQTIYERLDISVKERGESFYQSRMLSVVEYLRGKGLLEVDEGREIMWPDDTKTGIPLTIVKSDG 386
            |...||:.||:|:.||||||||.||..:|:....:|.::||:||:|::...  ..||||||||||
Human   318 ELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPG--CSIPLTIVKSDG 380

  Fly   387 GFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNPLSHRVDHVQFGVVL 451
            |:||||||:|||:.||.||..|.||||||:|||.||.|||.||:.....:|...||.|..|||||
Human   381 GYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVL 445

  Fly   452 GEDGKKFKTRSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELKDAQESLAYGCIKYSDLCH 516
            |||.||||||||:||:|.|||.||:|||:.:|:.:.||||||.:||..||.|:|||||||:||.|
Human   446 GEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSH 510

  Fly   517 NRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTNIVLDHEKEWKLA 581
            ||::||||||||||:||||||.||||.:|||.||||.:..|...|.:..::|.|:|||||||||.
Human   511 NRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLG 575

  Fly   582 KTLLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQ-GDIIGVNHSRILLCEA 645
            :.:|:..:||.|...:||||.||::.:|:.|.||||||||||:||::| |.|:.||..|:|||||
Human   576 RCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEA 640

  Fly   646 TAAVLRQCFYILGLKPVSKM 665
            .|||:.:.|.|||:|||.:|
Human   641 VAAVMAKGFDILGIKPVQRM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	43/89 (48%)
		PLN02286	83..665	CDD:215160	351/583 (60%)
		ArgRS_core	197..463	CDD:185675	174/265 (66%)
		DALR_1	540..665	CDD:214846	68/125 (54%)
RARS1	NP_002878.2	Could be involved in the assembly of the multisynthetase complex	1..72		29/76 (38%)
		tRNA-synt_1d	80..660	CDD:332079	351/583 (60%)
		L-arginine binding. /evidence=ECO:0000269\|PubMed:24859084, ECO:0007744\|PDB:4Q2T	200..202		1/1 (100%)
		'HIGH' region	201..212		9/10 (90%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q05506	529..543		10/13 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144329
Domainoid	1	1.000	444	1.000	Domainoid score	I535
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68281
Inparanoid	1	1.050	715	1.000	Inparanoid score	I643
Isobase	1	0.950	-	0	Normalized mean entropy	S1498
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	1	1.000	-	-		FOG0004174
OrthoInspector	1	1.000	-	-		oto89491
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720