Protein Alignment ArgRS and RARS1

DIOPT Version :10

• Sequence 1: NP_573081.1
• Gene: ArgRS / 32539
• FlyBaseID: FBgn0027093
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_002878.2
• Gene: RARS1 / 5917
• HGNCID: 9870
• Length: 660
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 383/670 - (57%)
• Similarity: 488/670 - (72%)
• Gaps: 19/670 - (2%)

  Fly     1 MSELNMELKKLRELELKTQGLAARIQTAKSGEQLDV--DLVQLQIENKKLKNRLFILKKSIAEES 63
            :||.:..|.: :|.|:|:  |.|.|...|:...|..  :|.|||.||.|||.||.||:||:..|.
Human     5 VSECSARLLQ-QEEEIKS--LTAEIDRLKNCGCLGASPNLEQLQEENLKLKYRLNILRKSLQAER 66

  Fly    64 TAAGGDVSKP-KESSSITEHLESVFRQAIASAFPEFRDTPVIIAPVNSTSAKFGDYQCNNAMGLS 127
                   :|| |...:|...|:.||..||.:|:|:..:.|:::.|  |..|||||||||:|||:|
Human    67 -------NKPTKNMINIISRLQEVFGHAIKAAYPDLENPPLLVTP--SQQAKFGDYQCNSAMGIS 122

  Fly   128 KKLKEKGINKAPRDIATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRNGVKPPE 192
            :.||.|.....||:||..:..|.|.:..|||:||||.||:||.|.||:.|..|::||.|||:.|.
Human   123 QMLKTKEQKVNPREIAENITKHLPDNECIEKVEIAGPGFINVHLRKDFVSEQLTSLLVNGVQLPA 187

  Fly   193 V-IKKRVLVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLIAHL 256
            : ..|:|:||||||||||:||||||||||||||:.||.||..:||:|:||:||||||||||||||
Human   188 LGENKKVIVDFSSPNIAKEMHVGHLRSTIIGESISRLFEFAGYDVLRLNHVGDWGTQFGMLIAHL 252

  Fly   257 EDRFPNYLNESPPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIKAWELICNVSRK 321
            :|:||:||..||||.|||:||||||||||.:||||||||..||.||...|:..|||:|||:|||:
Human   253 QDKFPDYLTVSPPIGDLQVFYKESKKRFDTEEEFKKRAYQCVVLLQGKNPDITKAWKLICDVSRQ 317

  Fly   322 EFQTIYERLDISVKERGESFYQSRMLSVVEYLRGKGLLEVDEGREIMWPDDTKTGIPLTIVKSDG 386
            |...||:.||:|:.||||||||.||..:|:....:|.::||:||:|::...  ..||||||||||
Human   318 ELNKIYDALDVSLIERGESFYQDRMNDIVKEFEDRGFVQVDDGRKIVFVPG--CSIPLTIVKSDG 380

  Fly   387 GFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNPLSHRVDHVQFGVVL 451
            |:||||||:|||:.||.||..|.||||||:|||.||.|||.||:.....:|...||.|..|||||
Human   381 GYTYDTSDLAAIKQRLFEEKADMIIYVVDNGQSVHFQTIFAAAQMIGWYDPKVTRVFHAGFGVVL 445

  Fly   452 GEDGKKFKTRSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELKDAQESLAYGCIKYSDLCH 516
            |||.||||||||:||:|.|||.||:|||:.:|:.:.||||||.:||..||.|:|||||||:||.|
Human   446 GEDKKKFKTRSGETVRLMDLLGEGLKRSMDKLKEKERDKVLTAEELNAAQTSVAYGCIKYADLSH 510

  Fly   517 NRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTNIVLDHEKEWKLA 581
            ||::||||||||||:||||||.||||.:|||.||||.:..|...|.:..::|.|:|||||||||.
Human   511 NRLNDYIFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQKAARETKILLDHEKEWKLG 575

  Fly   582 KTLLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQ-GDIIGVNHSRILLCEA 645
            :.:|:..:||.|...:||||.||::.:|:.|.||||||||||:||::| |.|:.||..|:|||||
Human   576 RCILRFPEILQKILDDLFLHTLCDYIYELATAFTEFYDSCYCVEKDRQTGKILKVNMWRMLLCEA 640

  Fly   646 TAAVLRQCFYILGLKPVSKM 665
            .|||:.:.|.|||:|||.:|
Human   641 VAAVMAKGFDILGIKPVQRM 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	PLN02286	83..665	CDD:215160	351/583 (60%)
RARS1	NP_002878.2	Could be involved in the assembly of the multisynthetase complex	1..72		29/76 (38%)
		PLN02286	80..660	CDD:215160	351/583 (60%)
		'HIGH' region	201..212		9/10 (90%)
		Interaction with tRNA. /evidence=ECO:0000250|UniProtKB:Q05506	529..543		10/13 (77%)