DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS and ArgRS-m

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_001262351.1	Gene:	ArgRS-m / 40929	FlyBaseID:	FBgn0037526	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	178/691 - (25%)
Similarity:	296/691 - (42%)	Gaps:	146/691 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LKKLRELELK-TQGLAARIQTAKSG-EQLDVDLVQLQIENKKLKNRLFILKKSIAEESTAAGGDV 70
            ||:|.|..:: .|.:..::...|:. ..|:|.:.:.|::|.:.....:||..:.|::.
  Fly    17 LKELTERMIRLRQAICEQLPHLKNACYALEVPVKKQQLQNSRRPTVEWILPSAFAQQE------- 74

  Fly    71 SKPKESSSITEHLESVFRQAIASAFPEFRDTPVIIAPVNSTSAKFGDYQCNNAMGLSKKLKEKGI 135
                     .|.|:|:.::    .|..:.:...|:.....::||. ::|....:.:.:.|:.|.|
  Fly    75 ---------VELLDSLKKR----RFEAYVENVRIVPSAGRSAAKI-EFQLQPQVFVEQLLQTKEI 125

  Fly   136 NKAPRDIATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRNGVKPPEVIKKRVLV 200
            ...|...|.|                                                   .::|
  Fly   126 ALHPSPFAAE---------------------------------------------------HIVV 139

  Fly   201 DFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLIAHLEDRFPNYLN 265
            ::|||||||..|||||||||||..|..|.|.|.:...|:|:|||||||||:|:..::     .||
  Fly   140 EYSSPNIAKPFHVGHLRSTIIGNVLANLHEHLGYRTTRLNYLGDWGTQFGLLVLGVQ-----LLN 199

  Fly   266 ES------PPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSI-KAWELICNVSRKEF 323
            .|      .||..|...|..:.|..::..|..::|.....:|:.|...|: |.|:...|.:.::.
  Fly   200 VSDKEMQLSPIETLYKSYVAANKAAEQRPEIAQQARDLFAALEGGTDKSMAKKWQQYRNYTIEDL 264

  Fly   324 QTIYERLDISVKE-RGESFY-QSRMLSVVEYLRGKGLLEVD-EGREIMWPDDTKTGIPLTIVKSD 385
            ..:|.||.:.... ..||.| |.::..|::.||..|||:.: :||||:..|    |..:.::||:
  Fly   265 SKVYNRLGVHFDSYEWESQYSQQQIQDVLDKLRSAGLLQPEHDGREIVVVD----GRRIPVIKSN 325

  Fly   386 GGFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNPLS-HRVDHVQFGV 449
            |...|...|:||:..||.......::||||:||:.|||.:||..  :|:.:.|| .::.||:||.
  Fly   326 GSTLYLARDIAALLERLSRFQFSRLLYVVDNGQADHFNALFKTT--AALDDRLSLEQLQHVKFGR 388

  Fly   450 VLGEDGKKFKTRSGDTVKLSDLLDEG--MKRSLQQLESRGRDKVLTPQELKDAQ--ESLAYGCIK 510
            :.|     ..||.|..:.|.|:|||.  :.|..:.:.:..|:.    ..|.|..  :.|....:.
  Fly   389 IYG-----MSTRQGKAIFLKDVLDEARDIMREKRNISATTREN----YNLDDEHVCDILGVSAVL 444

  Fly   511 YSDLCHNRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTNIVLDHE 575
            .:.|...|..|:.||:.:.|:..|:|.:.|.||:.|:.|:..|..:  .:|.:|          :
  Fly   445 VNVLKQRRQRDHEFSWQQALQVNGDTGIKLQYTHCRLHSLLDNFRD--VDLDDI----------K 497

  Fly   576 KEWKLAKT----------LLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKN--- 627
            .:||...|          .|...|..:..|||.         .|.|.:....:..|....:.
  Fly   498 PDWKHFSTEPADALDLLYALARFDQSVWQSKEQ---------LEACVLVNYLFGLCNATSQALKR 553

  Fly   628 ---KQGDIIGVNHSRILLCEATAAVLRQCFYILGLKPVSKM 665
               ||...:.....|:||..|....||....:|||:|:::|
  Fly   554 LPVKQESSLEKQLQRLLLFHAAKKTLRHGMELLGLRPLNQM 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	14/89 (16%)
		PLN02286	83..665	CDD:215160	163/612 (27%)
		ArgRS_core	197..463	CDD:185675	100/276 (36%)
		DALR_1	540..665	CDD:214846	31/140 (22%)
ArgRS-m	NP_001262351.1	ArgS	67..594	CDD:223097	165/639 (26%)
		nt_trans	137..397	CDD:294020	100/275 (36%)
		Anticodon_Ia_like	436..594	CDD:299868	40/178 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45444656
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.680