DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS and rars1

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_989403.1	Gene:	rars1 / 395040	XenbaseID:	XB-GENE-955966	Length:	660	Species:	Xenopus tropicalis

Alignment Length:	673	Identity:	384/673 - (57%)
Similarity:	499/673 - (74%)	Gaps:	26/673 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MEL------KKLRELELKTQGLAARIQTAKS-GEQLDV-DLVQLQIENKKLKNRLFILKKSIAEE 62
            |||      ::||:.|.:.:.|||.|:..|: |...:. .|..|:.||.|||.||.||:||:.||
Frog     1 MELPVCFYEERLRQQETEIKSLAAEIERLKNCGFVSETPSLEGLREENAKLKYRLNILRKSLLEE 65

  Fly    63 STAAGGDVSKPKESSS---ITEHLESVFRQAIASAFPEFRDTPVIIAPVNSTSAKFGDYQCNNAM 124
                     |.|.|.|   |...::.:|..||.:|:||.::.|:.:.|  |...||||||||:||
Frog    66 ---------KKKSSKSMININAQIQEIFGTAIGAAYPELQNAPLAVTP--SQQPKFGDYQCNSAM 119

  Fly   125 GLSKKLKEKGINKAPRDIATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRNGVK 189
            .:::.||......:||:||.::..:.|.:.::||::|||.||:||.|.||:.|..:|.||.|||:
Frog   120 AITQMLKAMNQKVSPREIADKIVKNIPTNELVEKVDIAGPGFINVHLHKDFTSKQISKLLVNGVQ 184

  Fly   190 PPEV-IKKRVLVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLI 253
            ||.: .:|:|:||||||||||:|||||||||:||:|:|||.||:.|||:|:||||||||||||||
Frog   185 PPVIWERKKVVVDFSSPNIAKEMHVGHLRSTVIGDSICRLFEFVGHDVLRLNHLGDWGTQFGMLI 249

  Fly   254 AHLEDRFPNYLNESPPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIKAWELICNV 318
            |||:|:||:||..||||.|||.||||||||||||||||||||..||.||...||.|:||.|||:|
Frog   250 AHLQDKFPDYLTVSPPIGDLQSFYKESKKRFDEDEEFKKRAYQCVVQLQNKTPNFIQAWNLICDV 314

  Fly   319 SRKEFQTIYERLDISVKERGESFYQSRMLSVVEYLRGKGLLEVDEGREIMWPDDTKTGIPLTIVK 383
            ||||||.||:.||||:.:|||||||.||:.||:....|||::|||||::::|..  ..:||||||
Frog   315 SRKEFQKIYDCLDISIIDRGESFYQDRMIGVVKEFEEKGLVQVDEGRKVVFPPG--CSVPLTIVK 377

  Fly   384 SDGGFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNPLSHRVDHVQFG 448
            |||||||||||:||::.||:||..|.||||:||||:.|...:|.|.......:|...|::|..||
Frog   378 SDGGFTYDTSDLAALKQRLQEEKADMIIYVIDSGQAIHMQNVFSAGRMIGWYDPKVTRIEHAGFG 442

  Fly   449 VVLGEDGKKFKTRSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELKDAQESLAYGCIKYSD 513
            ||||||.|||||||||||:|.||||||:|||:::|:.:|||||||.:||..||.|:|:|||||:|
Frog   443 VVLGEDKKKFKTRSGDTVRLIDLLDEGLKRSMEKLKDKGRDKVLTAEELLAAQTSVAFGCIKYAD 507

  Fly   514 LCHNRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTNIVLDHEKEW 578
            |.|||::||||||||||:||||||.||||.||||.||||.:.....:|.:..|:|.|:|:|||||
Frog   508 LSHNRMNDYIFSFDKMLDDRGNTAAYLLYAYTRIRSIARLANISDEDLHKAAKETEIILEHEKEW 572

  Fly   579 KLAKTLLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQ-GDIIGVNHSRILL 642
            ||:|.:|:..:||.|...:|.||.||::.:|:.|.||||||:|||:||::| |.|:.||.||:||
Frog   573 KLSKCILRFPEILQKILDDLLLHTLCDYLYELATTFTEFYDNCYCVEKDRQTGQIVKVNMSRLLL 637

  Fly   643 CEATAAVLRQCFYILGLKPVSKM 665
            |:|||||:.:.|.|||:|||.||
Frog   638 CDATAAVMAKGFDILGIKPVQKM 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	35/89 (39%)
		PLN02286	83..665	CDD:215160	350/583 (60%)
		ArgRS_core	197..463	CDD:185675	178/265 (67%)
		DALR_1	540..665	CDD:214846	68/125 (54%)
rars1	NP_989403.1	Could be involved in the assembly of the multisynthetase complex. /evidence=ECO:0000250	1..72		30/79 (38%)
		Syntaphilin	<9..>79	CDD:373718	29/78 (37%)
		PLN02286	79..660	CDD:215160	350/584 (60%)
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	200..202		1/1 (100%)
		'HIGH' region	201..212		9/10 (90%)
		Interaction with tRNA. /evidence=ECO:0000250\|UniProtKB:Q05506	529..543		11/13 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	476	1.000	Domainoid score	I430
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68281
Inparanoid	1	1.050	748	1.000	Inparanoid score	I575
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	1	1.000	-	-		FOG0004174
OrthoInspector	1	1.000	-	-		oto103316
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	1	1.000	-	-		X2924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110