DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArgRS and rars2

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_956911.1	Gene:	rars2 / 393589	ZFINID:	ZDB-GENE-040426-1244	Length:	597	Species:	Danio rerio

Alignment Length:	653	Identity:	184/653 - (28%)
Similarity:	307/653 - (47%)	Gaps:	134/653 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FRQA----IASAFPEFRDT--PVI-IAPVNSTSAKFGDYQCNNAMGL-SKKLKEKG-INKAPRDI 142
            ||::    :|.|..:..:|  |:| :||||...: ..|.:.:.:..| |..::..| :......:
Zfish     5 FRRSAALQLAKACGQNEETLIPLISVAPVNKKQS-VADLRVSVSHLLQSGAVRPDGDLQNTTHTL 68

  Fly   143 ATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRN-----GVKPPEVIKK----RV 198
            |.:::    ...::|:: |.|.|.::..|:|...:..|.:.||:     ||| .|::::    |.
Zfish    69 ARQIR----TDAVVEEI-IPGRGVIHFRLNKLLLAQKLLDQLRSDPDGFGVK-SEILRQLRVGRT 127

  Fly   199 LVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLIAHLEDRFPN- 262
            ||:||||||||:.|.|||||||||..:..|.:.|.::|||:|:|||||.|||:|.:..| ||.:
Zfish   128 LVEFSSPNIAKKFHAGHLRSTIIGNFIANLKKALGNEVIRVNYLGDWGMQFGLLGSGFE-RFGSQ 191

  Fly   263 ---------YLNES-----------------PPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSL 301
                     :|.||                 |.:      |.:..:..:.|...:..|......|
Zfish   192 EKLRTQPLEHLFESSVGGCCVYLYGSAVCVRPQV------YVQVNREAESDASVRSAAAHFFRRL 250

  Fly   302 QKGVPNSIKAWELICNVSRKEFQTIYERLDISVKE-RGESFYQSRMLSVVEYLRGKGLLEVDEGR 365
            ::....:::.|.....::..|::.||:||.:.... .||||:::...:|::.||.:.||:..:
Zfish   251 EQSEEQALELWRHFREITIHEYKRIYQRLGVEFDHYSGESFHRAETQTVLDELRSRCLLKTSQ-- 313

  Fly   366 EIMWPDDTKTGIP-----------LTIVKSDGGFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQS 419
                   ..||:.           .|:|:|||...|.|.|:||...|.:....|.:|||.|..|:
Zfish   314 -------KGTGVVDLSDKGDMSNYATLVRSDGTSLYITRDVAAALDRKQRFSFDEMIYVTDKSQT 371

  Fly   420 THFNTIFKAAERSAILNPLSHR----VDHVQFGVVLGEDGKKFKTRSGDTVKLSDLLDEGMKRSL 480
            .||..:|:      ||..:.|:    ..||.||:|.|     ..||.|:.:.|.|:|:|...|.:
Zfish   372 MHFQQLFR------ILQAMGHQWAGSCHHVAFGLVQG-----MSTRRGEVLFLEDVLEEAQSRMI 425

  Fly   481 QQL-ESRGRDKVLTPQELKDAQ---ESLAYGCIKYSDLCHNRISDYIFSFDKMLEDRGNTAVYLL 541
            ..: :||      |.:||:|.:   |.:....:...|.....||||.|.:||:|:.:|:|.|:|.
Zfish   426 HNMRQSR------TSKELEDPELTAERIGISALIVQDFKGPLISDYRFEWDKVLQAQGDTGVFLQ 484

  Fly   542 YTYTRICSIARN-----SGEDFTNLPEILKKTNIVLDHEKEWKLAKTLLKLHDILIKCSKEL--- 598
            ||:.|:||:.|.     |..||:.|.:  .::..:|.|         ||:..::|::|:.:|
Zfish   485 YTHARLCSLLRQQDCEISCSDFSPLTD--SRSVSLLQH---------LLRYDEVLLQCATDLQPK 538

  Fly   599 -FLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQGDIIGVNHSRILLCEATAAVLRQCFYILGLKPV 662
             .::||......|.:...|.         ..:|....|..:|:.|..:..:||.....|||:.||
Zfish   539 HLVNFLMTLSHLVASAHREL---------PVKGSSEAVAQARLCLFSSVHSVLANGMRILGITPV 594

  Fly   663 SKM 665
            .||
Zfish   595 DKM 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	20/92 (22%)
		PLN02286	83..665	CDD:215160	182/651 (28%)
		ArgRS_core	197..463	CDD:185675	95/308 (31%)
		DALR_1	540..665	CDD:214846	33/133 (25%)
rars2	NP_956911.1	argS	59..597	CDD:234964	168/596 (28%)
		ArgRS_core	126..408	CDD:185675	95/308 (31%)
		Anticodon_Ia_like	445..597	CDD:299868	46/171 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760