DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS and rars1

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_956342.1	Gene:	rars1 / 337070	ZFINID:	ZDB-GENE-030131-9014	Length:	661	Species:	Danio rerio

Alignment Length:	671	Identity:	383/671 - (57%)
Similarity:	504/671 - (75%)	Gaps:	20/671 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSELNMELKKLRELELKTQGLAARIQTAKSGEQLDV---DLVQLQIENKKLKNRLFILKKSIAEE 62
            ::|....||: :|.|:|.  |...|:..:..:.|::   .|.:|:.||.:||.||.|||:|:.||
Zfish     5 VTEYASRLKR-QEREIKL--LQDEIERLRDPQDLNLTSSQLDELREENSRLKYRLNILKRSLQEE 66

  Fly    63 STAAGGDVSKPKESSSITEHLESVFRQAIASAFPEFRDTPVIIAPVNSTSAKFGDYQCNNAMGLS 127
            ....|      |...:|.:.|:.:|.:||:||:|:..:.|:.:.|  |..|||||||||:||.:|
Zfish    67 MNHNG------KTMLNINQLLQQIFGEAISSAYPDLENPPLSVTP--SQQAKFGDYQCNSAMAMS 123

  Fly   128 KKLKEKGINKAPRDIATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRNGVKPPE 192
            :.:|.||:..:||:||.::..:.|.:.:|||.||||.||:||.|.:::.|..|||:|.|||:||.
Zfish   124 QMMKAKGLKVSPREIAEKIVQNIPNNDLIEKTEIAGPGFINVHLKRNFVSKLLSNVLVNGVQPPP 188

  Fly   193 V-IKKRVLVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLIAHL 256
            : .||:|:||||||||||:||||||||||||:|:|||.|||.::|:|:||:||||||||||||||
Zfish   189 LQKKKKVIVDFSSPNIAKEMHVGHLRSTIIGDSMCRLFEFLGYEVLRLNHVGDWGTQFGMLIAHL 253

  Fly   257 EDRFPNYLNESPPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIKAWELICNVSRK 321
            :|:|||||:.||||.|||.||||||||||||||||||||..||.||....:.||||.|||:||||
Zfish   254 QDKFPNYLSVSPPIGDLQAFYKESKKRFDEDEEFKKRAYKCVVKLQSKEADFIKAWNLICDVSRK 318

  Fly   322 EFQTIYERLDISVKERGESFYQSRMLSVVEYLRGKGLLEVDEGREIMW-PDDTKTGIPLTIVKSD 385
            |||.:|..||||:||||||:||..|.:||:....|||:||||||:|:: |..:   |||||||||
Zfish   319 EFQKVYNCLDISIKERGESYYQDMMTAVVKEFEEKGLVEVDEGRKIVFAPGQS---IPLTIVKSD 380

  Fly   386 GGFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNPLSHRVDHVQFGVV 450
            ||:||||||:||||:||.:|..|.||||.||||:.||..||.||:.....:|...||:|..||||
Zfish   381 GGYTYDTSDLAAIRNRLFDEKADIIIYVTDSGQAMHFQVIFAAAQLIGWYDPKVTRVEHAGFGVV 445

  Fly   451 LGEDGKKFKTRSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELKDAQESLAYGCIKYSDLC 515
            ||||.|||||||||||:|.|||:||:|||:.:|:.:.|||||||:||:.||.::|:|||||:||.
Zfish   446 LGEDKKKFKTRSGDTVRLMDLLEEGLKRSMDKLKEKERDKVLTPEELEKAQRAVAFGCIKYADLS 510

  Fly   516 HNRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTNIVLDHEKEWKL 580
            ||||:||:|||||||:||||||.||||.:|||.||||.:......|.:..:.|:::|||||||||
Zfish   511 HNRINDYVFSFDKMLDDRGNTAAYLLYAFTRIRSIARLANIQEAALRKAAETTDVILDHEKEWKL 575

  Fly   581 AKTLLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQ-GDIIGVNHSRILLCE 644
            .|.:|:..:||.|.:.:|.||.||::.:|:.|.||||||||||:||::| |:::.||..|:||||
Zfish   576 GKCILRFPEILQKITDDLLLHTLCDYLYELATTFTEFYDSCYCVEKDRQTGEVVKVNMWRMLLCE 640

  Fly   645 ATAAVLRQCFYILGLKPVSKM 665
            |||||:.:.|.|||:.||.:|
Zfish   641 ATAAVMAKGFDILGINPVQRM 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	41/89 (46%)
		PLN02286	83..665	CDD:215160	356/584 (61%)
		ArgRS_core	197..463	CDD:185675	183/266 (69%)
		DALR_1	540..665	CDD:214846	65/125 (52%)
rars1	NP_956342.1	MreC	<5..>58	CDD:302802	17/55 (31%)
		PLN02286	79..661	CDD:215160	356/586 (61%)
		Arg_tRNA_synt_N	79..167	CDD:214975	41/89 (46%)
		ArgRS_core	194..458	CDD:185675	183/266 (69%)
		Anticodon_Ia_like	497..661	CDD:299868	93/163 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577403
Domainoid	1	1.000	472	1.000	Domainoid score	I422
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68281
Inparanoid	1	1.050	740	1.000	Inparanoid score	I576
OMA	1	1.010	-	-		QHG60659
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	1	1.000	-	-		FOG0004174
OrthoInspector	1	1.000	-	-		oto41747
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	1	1.100	-	-	LDO	PTHR11956
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	1	1.000	-	-		X2924
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800