Protein Alignment ArgRS and Rars1

DIOPT Version :10

• Sequence 1: NP_573081.1
• Gene: ArgRS / 32539
• FlyBaseID: FBgn0027093
• Length: 665
• Species: Drosophila melanogaster
• Sequence 2: NP_001099247.2
• Gene: Rars1 / 287191
• RGDID: 1309215
• Length: 660
• Species: Rattus norvegicus
• Alignment Length: 661
• Identity: 369/661 - (55%)
• Similarity: 484/661 - (73%)
• Gaps: 16/661 - (2%)

  Fly    10 KLRELELKTQGLAARIQTAKSGEQLDV--DLVQLQIENKKLKNRLFILKKSIAEESTAAGGDVSK 72
            :|.:.|.:.:.|.|.|...|:...|:.  .|.||:.||.|||.||.||::|:..|.       .:
  Rat    11 RLLQQEKEIKSLTAEIDRLKNCSYLEASPSLEQLREENLKLKYRLNILRRSLQAER-------KR 68

  Fly    73 P-KESSSITEHLESVFRQAIASAFPEFRDTPVIIAPVNSTSAKFGDYQCNNAMGLSKKLKEKGIN 136
            | |...:|...|:.:|..||.:|:|:..:.|:::.|  |...||||||||:|||:|:.||.|...
  Rat    69 PTKNMININSRLQELFGCAIKAAYPDLENPPLVVTP--SQQPKFGDYQCNSAMGISQMLKAKEQK 131

  Fly   137 KAPRDIATELKGHCPASPIIEKLEIAGAGFVNVFLSKDYASLALSNLLRNGVKPPEV-IKKRVLV 200
            .:||:||..:..|.|.:..|:::||||.||:||.|.||:.|..|:|||.|||:.|.: ..::|:|
  Rat   132 VSPREIAENITKHLPNNEYIDRVEIAGPGFINVHLRKDFVSEQLTNLLVNGVQLPVLGENEKVIV 196

  Fly   201 DFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGMLIAHLEDRFPNYLN 265
            |||||||||:||||||||||||||:.||.||..::|:|:||:||||||||||||||:|:||:||.
  Rat   197 DFSSPNIAKEMHVGHLRSTIIGESMSRLFEFAGYNVLRLNHVGDWGTQFGMLIAHLQDKFPDYLT 261

  Fly   266 ESPPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIKAWELICNVSRKEFQTIYERL 330
            .||||.|||.||||||||||.:||||||||..||.||...|:.:|||.|||:|||:||..||:.|
  Rat   262 VSPPIGDLQAFYKESKKRFDTEEEFKKRAYECVVLLQSKNPDIMKAWNLICDVSREEFNKIYDAL 326

  Fly   331 DISVKERGESFYQSRMLSVVEYLRGKGLLEVDEGREIMWPDDTKTGIPLTIVKSDGGFTYDTSDM 395
            ||::.||||||||.||..:|:....||.::||:||:|::...  ..:||||||||||:||||||:
  Rat   327 DITLIERGESFYQDRMKDIVKEFEDKGFVQVDDGRKIVFVPG--CSVPLTIVKSDGGYTYDTSDL 389

  Fly   396 AAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNPLSHRVDHVQFGVVLGEDGKKFKT 460
            |||:.||.||..:.||||||:||:|||.|:|.||:.....:|...||.||.||||||||.|||||
  Rat   390 AAIKQRLFEEKANKIIYVVDNGQATHFQTVFAAAQMIGWYDPKVTRVAHVGFGVVLGEDKKKFKT 454

  Fly   461 RSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELKDAQESLAYGCIKYSDLCHNRISDYIFS 525
            |||:||:|.|||:||::||:.:|:.:.||||||.:|||.||.|:|||||||:||.|||::||:||
  Rat   455 RSGETVRLMDLLEEGLRRSMDKLKEKERDKVLTEEELKAAQTSVAYGCIKYADLSHNRLNDYVFS 519

  Fly   526 FDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTNIVLDHEKEWKLAKTLLKLHDI 590
            |||||:||||||.||||.:|||.||||.:..|...|....::|.|:|||||||||.:.:|:..:|
  Rat   520 FDKMLDDRGNTAAYLLYAFTRIRSIARLANIDEEMLQRAARETKIILDHEKEWKLGRCILRFPEI 584

  Fly   591 LIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQ-GDIIGVNHSRILLCEATAAVLRQCF 654
            |.|...:||||.||::.:|:.|.||||||||||:||::| |.::.||..|:|||||.|||:.:.|
  Rat   585 LQKILDDLFLHTLCDYIYELATTFTEFYDSCYCVEKDRQTGKVLKVNMWRMLLCEAVAAVMAKGF 649

  Fly   655 YILGLKPVSKM 665
            .|||:|||.:|
  Rat   650 DILGIKPVQRM 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	PLN02286	83..665	CDD:215160	344/583 (59%)
Rars1	NP_001099247.2	Could be involved in the assembly of the multisynthetase complex. /evidence=ECO:0000250	1..72		22/67 (33%)
		PLN02286	80..660	CDD:215160	344/583 (59%)
		'HIGH' region. /evidence=ECO:0000250	201..212		9/10 (90%)
		Interaction with tRNA. /evidence=ECO:0000250|UniProtKB:Q05506	529..543		10/13 (77%)