DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ArgRS and Rars2

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	NP_852071.2	Gene:	Rars2 / 109093	MGIID:	1923596	Length:	578	Species:	Mus musculus

Alignment Length:	617	Identity:	184/617 - (29%)
Similarity:	301/617 - (48%)	Gaps:	81/617 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FRQAIASAF-------PEFRDTPVIIAPVNSTSAKFGDYQCNNAMGLSKKLKEKGINKAPRDIAT 144
            ||::||...       ||.....:...|| |...:..|:|.:     ...|.|...:|:..|...
Mouse     5 FRRSIACQLSRVLALPPESLIKSISAVPV-SKKEEVADFQLS-----VDSLLEDNNHKSQVDTQD 63

  Fly   145 ELKGHCPASPIIEKLEI--------AGAGFVNVFLSKDYASLA-LSNLLRNGVKP-------PEV 193
            :      |..:.|||:.        ||...:|..::::..:.| |..:..:|.|.       .::
Mouse    64 Q------ARRLAEKLKCDTVVTAISAGPRTLNFKINRELLTKAVLQQVTEDGCKYGLKSELFSDL 122

  Fly   194 IKKRVLVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQFGML-----I 253
            .|||::|:||||||||:.|||||||||||..:..|.|.|.|.|.|||::||||.|||:|     :
Mouse   123 PKKRIVVEFSSPNIAKKFHVGHLRSTIIGNFIANLKEALGHQVTRINYIGDWGMQFGLLGTGFQL 187

  Fly   254 AHLEDRFPNYLNESPPISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIKAWELICNV 318
            ...|::.     ::.|:..|...|.:..|...:|:...|.|:.....|:.|...::..|:...::
Mouse   188 FGYEEKL-----QTNPLQHLFDVYVQVNKEATDDKNVTKLAHEFFHRLEMGDTQALSLWQRFRDL 247

  Fly   319 SRKEFQTIYERLDISVKE-RGESFYQSRMLSVVEYLRGKGLLE-VDEGREIMWPDDTKTG---IP 378
            |.:|:..||:||.|...| .|||||:.:...|::.|..||||: ..||..::  |.:.||   ..
Mouse   248 SIEEYTQIYKRLGIYFDEYSGESFYREKSQDVLKLLDSKGLLQKTAEGNVVV--DLSGTGDLSSV 310

  Fly   379 LTIVKSDGGFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILN-PLSHRV 442
            .|:::|||...|.|.|:||..||:::...|.:|||.|.||..||..:|:..:   |:. ..:.|.
Mouse   311 CTVMRSDGTSLYATRDLAAAIHRMDKYNFDTMIYVADKGQRRHFQQVFQMLK---IMGYDWAERC 372

  Fly   443 DHVQFGVVLGEDGKKFKTRSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELKDAQES---L 504
            .||.||:|.|     .|||.|....|.|:|:|...|.||.:.|     :.|.::|::.||:   :
Mouse   373 QHVPFGIVKG-----MKTRRGGVTFLEDVLNEVQSRMLQNMAS-----IKTTKQLENPQETAERV 427

  Fly   505 AYGCIKYSDLCHNRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSIARNSGEDFTNLPEILKKTN 569
            ....:...|.....:|||.||:|::.:.||:|.|:|.||:.|:||:....|..:.|      .:|
Mouse   428 GLAAVIIQDFRGTLLSDYQFSWDRVFQSRGDTGVFLQYTHARLCSLEETFGCGYLN------DSN 486

  Fly   570 IV-LDHEKEWKLAKTLLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDSCYCIEKNKQGDII 633
            :. |...:...:.:.||:..::|...|::|....:..:...:..:....:.:...  |:...|:.
Mouse   487 VACLQEPQSVSILQHLLRFDEVLYLSSQDLQPKHIVSYLLTLSHLAAVAHKTLQV--KDSPPDVA 549

  Fly   634 GVNHSRILLCEATAAVLRQCFYILGLKPVSKM 665
            |   :|:.|.:|..:||.....:||:.||.:|
Mouse   550 G---ARLHLFKAVRSVLANGMKLLGITPVCRM 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	22/98 (22%)
		PLN02286	83..665	CDD:215160	183/615 (30%)
		ArgRS_core	197..463	CDD:185675	104/276 (38%)
		DALR_1	540..665	CDD:214846	27/125 (22%)
Rars2	NP_852071.2	ArgS	30..578	CDD:223097	177/590 (30%)
		ArgRS_core	126..388	CDD:185675	104/276 (38%)
		'HIGH' region	133..144		8/10 (80%)
		L-arginine binding. /evidence=ECO:0000250\|UniProtKB:P54136	133..135		1/1 (100%)
		Anticodon_Ia_like	425..578	CDD:299868	38/163 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0018
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60659
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100350
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750