DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ArgRS and rars2

DIOPT Version :9

Sequence 1:	NP_573081.1	Gene:	ArgRS / 32539	FlyBaseID:	FBgn0027093	Length:	665	Species:	Drosophila melanogaster
Sequence 2:	XP_002933968.2	Gene:	rars2 / 100488556	XenbaseID:	XB-GENE-976890	Length:	576	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	167/565 - (29%)
Similarity:	270/565 - (47%)	Gaps:	73/565 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 EKGINKAPRDIATELKGHCPASPIIEKLEIAGAGF------------VNVFLSKDYASLALSNLL 184
            :..||...|  |.:|.|......:|..:..|.|..            |...:|||.:...|:..|
Frog    54 DTSINHEER--AQQLAGKLVCDSVISDIGTARASVTFKINRDLLTRTVLQQISKDGSIYGLNTEL 116

  Fly   185 RNGVKPPEVIKKRVLVDFSSPNIAKQMHVGHLRSTIIGESLCRLLEFLQHDVIRINHLGDWGTQF 249
            .:|:.     .::.:|::|||||||:.|||||||||||..:..|.:.:.::|||||:|||||.||
Frog   117 FSGLS-----GRKTVVEYSSPNIAKKFHVGHLRSTIIGNFIANLKQAVGNEVIRINYLGDWGLQF 176

  Fly   250 GMLIAHLEDRFPNYLNESP----PISDLQLFYKESKKRFDEDEEFKKRAYSRVVSLQKGVPNSIK 310
            |:|.|    .|..:.:|..    |:..|...|.:.....:||::.|..|...:..|:.|.|:::.
Frog   177 GLLGA----GFSKFGSEEELVVNPLQHLFEVYVKVNTAAEEDKDIKLSAQEFLRRLEGGDPHALS 237

  Fly   311 AWELICNVSRKEFQTIYERLDISVKE-RGESFYQSRMLSVVEYLRGKGLLE-VDEGREIM-WPDD 372
            .|....::|.:|:..:|:||.....: .|||||:.:...|::.|...|||: .|:|..:: ..::
Frog   238 LWMHFRDLSIQEYAKVYKRLGAHFDDYSGESFYKEKSQEVLKQLESNGLLQKTDKGTGVVDLSEE 302

  Fly   373 TKTGIPLTIVKSDGGFTYDTSDMAAIRHRLEEELCDWIIYVVDSGQSTHFNTIFKAAERSAILNP 437
            .......|:::|||...|.|.|:||...|||....|.:|||.|..|..||..:||      ||..
Frog   303 GNLSSYSTVMRSDGTSLYITRDVAAALDRLERYSFDEMIYVTDKSQKNHFQQLFK------ILKI 361

  Fly   438 L----SHRVDHVQFGVVLGEDGKKFKTRSGDTVKLSDLLDEGMKRSLQQLESRGRDKVLTPQELK 498
            |    :.|..||.||:|.|     .|||.|:.|.|.|:|||...|.||.:.:.|..|.|  ::..
Frog   362 LGKDQADRFQHVPFGLVKG-----MKTRRGEVVFLEDVLDEARSRMLQNMAASGTSKQL--EDPS 419

  Fly   499 DAQESLAYGCIKYSDLCHNRISDYIFSFDKMLEDRGNTAVYLLYTYTRICSI-----ARNSGE-D 557
            |..|.:....:...|.....:|||.|.:|:.|:..|:|.|:|.||:.|:.|:     :|::.: |
Frog   420 DTAEKIGIAALIVQDFKGQLLSDYHFDWDQALQSTGDTGVFLQYTHARLHSLQALWCSRDTDDID 484

  Fly   558 FTNL--PEILKKTNIVLDHEKEWKLAKTLLKLHDILIKCSKELFLHFLCEFCFEVCTVFTEFYDS 620
            ..:|  |.::    ..|.|         ||:..:::.||.::|...:|..:...:..:....:.:
Frog   485 IASLREPCVI----ATLQH---------LLRYDEVIYKCLEDLQPRYLVTYLMSLGHLANVAHRA 536

  Fly   621 CYCIEKNKQGDIIGVNHSRILLCEATAAVLRQCFYILGLKPVSKM 665
            .:....:.:     ..|:|:........||.....:||:.||:.|
Frog   537 LHVKRSSSE-----AAHARLFFFNNVRMVLSSGMKLLGISPVNNM 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ArgRS	NP_573081.1	Arg_tRNA_synt_N	81..171	CDD:214975	10/50 (20%)
		PLN02286	83..665	CDD:215160	166/563 (29%)
		ArgRS_core	197..463	CDD:185675	100/276 (36%)
		DALR_1	540..665	CDD:214846	25/132 (19%)
rars2	XP_002933968.2	ArgS	58..576	CDD:223097	165/559 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D463402at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1455
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.040