DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8565 and SRPK2

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_024302662.1	Gene:	SRPK2 / 6733	HGNCID:	11306	Length:	767	Species:	Homo sapiens

Alignment Length:	675	Identity:	231/675 - (34%)
Similarity:	323/675 - (47%)	Gaps:	133/675 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 GSGFDRQESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVSKSA 237
            ||..:.||...:|..||||||.|||:|..||||.:|||||||||||||:|.|..|:.|:||.|||
Human    99 GSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSA 163

  Fly   238 QVYKETGIDEIMLFSQMSLHD-QHKYRSHVVGFYDFFEITGPHGRHICLVLEVLGDNLLKVIERC 301
            |.|.||.:|||.|...:...| ....:..||...|.|:|:|.:|.|:|:|.||||.:|||.|.:.
Human   164 QHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKS 228

  Fly   302 FYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANE 366
            .|:|:|:..:|.|.:|||.||.:||.:|.|||||:||||:|:..::..||.....|.| :.||..
Human   229 NYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATE-WQKAGA 292

  Fly   367 GKLS-----------PSSKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAERGLIEP 420
            ...|           |..|::|..|::::.|.|:.....:.     |.|.||:|...|||.:||.
Human   293 PPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEK-----RLQEIEELEREAERKIIEE 352

  Fly   421 -ITAAMAVSDN----LPFIPFGFDGFMMMSDA-------DCRTVQNSKLPEMEGMEYKCDRIN-- 471
             ||:|...:|.    .|.:.....|....::|       :....:..:..|.|.:|...|.::
Human   353 NITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQE 417

  Fly   472 ------LCLKSPE---------LFLRYVLD-------IIKNLDEKELSTQDKRRRFTQAS----- 509
                  ..::||:         ..|...||       ...|.:|..|...:....:|.:|
Human   418 LANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQF 482

  Fly   510 ---------------------------------------GRGQTKKNARSRLRLASNAAYTTGTG 535
                                                   |...|::...|.....|.....:.||
Human   483 NGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTG 547

  Fly   536 WRSNRKINLND--IYPIDPANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCE 598
            .....|....|  :.|:||.|.: .:|||||||||||:.|.|||:||||::||::||::||||..
Human   548 DLPKAKTRAADLLVNPLDPRNAD-KIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYST 611

  Fly   599 TADIWSVACLLWELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFIN-- 661
            .|||||.||:.:|||||.|||:.||.. .|:.||.|||.|:|..|.||.:....||:||.|.|
Human   612 PADIWSTACMAFELATGDYLFEPHSGE-DYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRR 675

  Fly   662 -----------------------------SAGKLCNIETLKPLKLANILIRWYGWRTRQSTEFVN 697
                                         ..|:|.:|..|||..|.::|:..|||....:.:|.:
Human   676 DHIALIIELLGKVPRKYAMLGKYSKEFFTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTD 740

  Fly   698 FLMPMLQTNPLSRISASKALESHYL 722
            ||:|||:..|..|.||.:.|...:|
Human   741 FLIPMLEMVPEKRASAGECLRHPWL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	221/654 (34%)
SRPK2	XP_024302662.1	STKc_SRPK2	116..>304	CDD:271119	91/188 (48%)
		Na_Ca_ex	<389..431	CDD:332332	6/41 (15%)
		PKc_like	<552..765	CDD:328722	89/214 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143101
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.610