Protein Alignment CG8565 and SRPK1

DIOPT Version :9

• Sequence 1: NP_573080.1
• Gene: CG8565 / 32538
• FlyBaseID: FBgn0030697
• Length: 790
• Species: Drosophila melanogaster
• Sequence 2: NP_003128.3
• Gene: SRPK1 / 6732
• HGNCID: 11305
• Length: 655
• Species: Homo sapiens
• Alignment Length: 698
• Identity: 237/698 - (33%)
• Similarity: 335/698 - (47%)
• Gaps: 144/698 - (20%)

  Fly   113 KKRCKQKRRMPSSLSDDGIAGRKPAKINKYSELSYGSESSMPFEMKQQSNDNQNNNDNAEGSGFD 177
            |||.|.|:......|:....|..|           .|||.:|           ...:...||..|
Human    12 KKRTKAKKDKAQRKSETQHRGSAP-----------HSESDLP-----------EQEEEILGSDDD 54

  Fly   178 RQESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVSKSAQVYKE 242
            .||..|:|..||||.|.|||:|..||||.:||||||||||||.:|.|..::.|:||.|||:.|.|
Human    55 EQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTE 119

  Fly   243 TGIDEIMLFSQMSLHDQH-KYRSHVVGFYDFFEITGPHGRHICLVLEVLGDNLLKVIERCFYKGM 306
            |.:|||.|...:...|.: ..|..||...|.|:|:|.:|.|||:|.||||.:|||.|.:..|:|:
Human   120 TALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGL 184

  Fly   307 PISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANEGKLS- 370
            |:..:|:|.||||.||.:||.:|.|||||:||||:||:.||..:|   :.|.|    |.|.:.|
Human   185 PLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIR---RLAAE----ATEWQRSG 242

  Fly   371 ----------------PSSKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAERGLIE 419
                            |:.||:|..|::::.|.|:.....:.     |.|.||::...:..|...
Human   243 APPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEK-----RMQEIEEMEKESGPGQKR 302

  Fly   420 P-------ITAAMAVSDNLP----------FIPFGFDGFMMMSDADCRTVQNSKLPEMEGMEYKC 467
            |       ......:.:|.|          ....|.|..:|..|.           |....|..|
Human   303 PNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDT-----------EGGAAEINC 356

  Fly   468 ----DRINLCLKSPELFLRYVLDI-------IKNLDEKE--LSTQDKRRRFTQASGRGQTKKNAR 519
                :.||....|....||:..|:       ::||:::.  ||:|         :|...|.:...
Human   357 NGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQ---------NGDSSTSQETD 412

  Fly   520 SRLRLAS--------NAAYTTGTGWRSNRKINLND------------------------------ 546
            |...:.|        .::.|.|..:.......|.:
Human   413 SCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGN 477

  Fly   547 --IYPIDPANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSVACLL 609
              :.|::|.|.| .::||||||||||:.|.|||:||||::||:|||::|:||...|||||.||:.
Human   478 FLVNPLEPKNAE-KLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMA 541

  Fly   610 WELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFINSAGKLCNIETLKP 674
            :|||||.|||:.||.. :|..||.|||.|:|..|::|..||..||:|:.|....|.|.:|..|||
Human   542 FELATGDYLFEPHSGE-EYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKP 605

  Fly   675 LKLANILIRWYGWRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYL 722
            ..|..:|:..|.|...::..|.:||:|||:..|..|.:|::.|...:|
Human   606 WGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWL 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	213/617 (35%)
SRPK1	NP_003128.3	PKc_like	69..>282	CDD:389743	97/219 (44%)
		STKc_SRPK1	<477..653	CDD:271118	83/177 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143102
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.710