Protein Alignment CG8565 and MAPK13

DIOPT Version :10

• Sequence 1: NP_573080.1
• Gene: CG8565 / 32538
• FlyBaseID: FBgn0030697
• Length: 790
• Species: Drosophila melanogaster
• Sequence 2: NP_002745.1
• Gene: MAPK13 / 5603
• HGNCID: 6875
• Length: 365
• Species: Homo sapiens
• Alignment Length: 620
• Identity: 110/620 - (17%)
• Similarity: 180/620 - (29%)
• Gaps: 320/620 - (51%)

  Fly   199 FVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAV-KVSK--SAQVYKETGIDEIMLFSQMSLHDQH 260
            :|:..||    |.|.:.:|....|.:.....|: |:|:  .::::.:....|::|..    |.||
Human    25 YVSPTHV----GSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSEIFAKRAYRELLLLK----HMQH 81

  Fly   261 KYRSHVVG-------------FYDFFEITGPHGRHICLVLEVLGDNLLKVIERCFYKGMPIS--N 310
            :   :|:|             ||||:           ||:..:..:|.|::      ||..|  .
Human    82 E---NVIGLLDVFTPASSLRNFYDFY-----------LVMPFMQTDLQKIM------GMEFSEEK 126

  Fly   311 IKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANEGKLSPSSKM 375
            |:.:..|:|.|||::| ..|::|.||||.|  ||.||
Human   127 IQYLVYQMLKGLKYIH-SAGVVHRDLKPGN--LAVNE---------------------------- 160

  Fly   376 TKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAERGLIEPITAAMAVSDNLPFIPFGFDG 440
                                                                             
Human   161 ----------------------------------------------------------------- 160

  Fly   441 FMMMSDADCRTVQNSKLPEMEGMEYKCDRINLCLKSPELFLRYVLDIIKNLDEKELSTQDKRRRF 505
                   ||
Human   161 -------DC-------------------------------------------------------- 162

  Fly   506 TQASGRGQTKKNARSRLRLASNAAYTTGTGWRSNRKINLNDIYPIDPANNECDVRVKIADLGNAC 570
                                                                  .:||.|.|.|.
Human   163 ------------------------------------------------------ELKILDFGLAR 173

  Fly   571 YFHHHFTDDIQTKEYRALEVILG-AGYCETADIWSVACLLWELATGTYLFDTHSKRGKYNLDEVH 634
            :.....|..:.|:.|||.||||. ..|.:|.|||||.|::.|:.||..||     :||..||:
Human   174 HADAEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLF-----KGKDYLDQ-- 231

  Fly   635 IAKIVETCGRIPWYLIRK--GKHSRNFINSAGKLCNIETLKPLKLANILIRWYGWRTRQSTEFVN 697
            :.:|::..|......::|  .|.::::|.|..:       .|.|....|.      .|.|.:..:
Human   232 LTQILKVTGVPGTEFVQKLNDKAAKSYIQSLPQ-------TPRKDFTQLF------PRASPQAAD 283

  Fly   698 FLMPMLQTNPLSRISASKALESHYLCNIALPGIDIDSYYYYSVREIKDCTHTKSE--RNSDEDSS 760
            .|..||:.:...|::|::||                             ||...|  |:.:|::.
Human   284 LLEKMLELDVDKRLTAAQAL-----------------------------THPFFEPFRDPEEETE 319

  Fly   761 SCSSIDSS----EFSSDE---VCYEDDVNEEDIKK 788
            :....|.|    :.:.||   ..|::.||...|.:
Human   320 AQQPFDDSLEHEKLTVDEWKQHIYKEIVNFSPIAR 354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	Protein Kinases, catalytic domain	192..722	CDD:473864	97/543 (18%)
MAPK13	NP_002745.1	STKc_p38delta	9..351	CDD:143384	109/615 (18%)
		TXY	180..182		1/1 (100%)