DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8565 and Srpk79D

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001246881.1	Gene:	Srpk79D / 40461	FlyBaseID:	FBgn0025702	Length:	1018	Species:	Drosophila melanogaster

Alignment Length:	735	Identity:	224/735 - (30%)
Similarity:	321/735 - (43%)	Gaps:	213/735 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 DNAEGSGF---DRQESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCA 230
            |:::.|.:   :.||.|::|..||||||.|||:|.||:.|.:|||||||||||||.|.:.::|.|
  Fly   310 DSSDSSLYVSDEEQEDASQYCRGGYHPVVIGDIFDNRFRVVRKLGWGHFSTVWLCRDLKDEKYVA 374

  Fly   231 VKVSKSAQVYKETGIDEIMLFSQMSLHD-QHKYRSHVVGFYDFFEITGPHGRHICLVLEVLGDNL 294
            :||.|||..|.||..|||.|...:...| ....|..:|...:.|.:.|.:|.|.|||.|.||.:|
  Fly   375 LKVVKSAPHYIETAADEIRLLEAIRDADPMDVKRERIVRLMNHFTVRGVNGMHTCLVFEALGCSL 439

  Fly   295 LKVIERCFYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLA-SNEVSVRTEIK--- 355
            .|:|.:..|:|:.|:.::.|.:|||.||.:||.:|.|||||:||||:||. .|..::..:|.
  Fly   440 YKLIVKNNYQGLAIAQVRNIIRQVLEGLDYLHSKCSIIHTDIKPENILLVIDNAAAMNQQIDDEI 504

  Fly   356 ---------------TAIEVYLKA-------------------------NEGKLSP--------- 371
                           ::||...|:                         |....:|
  Fly   505 NSLRVKGVDFPDSYISSIEKQTKSRAKWPLIEPNGSTNTNTNTSNSTATNSNSSTPLAAVIMSTL 569

  Fly   372 ---------SSKMTKTAKRRMQAK----------------SKKVISFFKNHRRMLRRQG---IED 408
                     ||.:.......:.:|                |..:.:.::..:::..:..   .||
  Fly   570 DKEDTTTTTSSTLNSNTTSSLASKYSSLLGDSECNGGLGGSANINNRYRTEKKITAKSSGDCDED 634

  Fly   409 LLYLAERGLI-EPITAAMAVS-----------DNLP-FIPFGFDGFM------MMSDADC----- 449
                ||...: |..|.|..:.           |:.| .:|...:|.:      ..:::.|
  Fly   635 ----AESDTLGEQSTLASTMDSPTDLDPEPELDSKPNTVPEPSEGPIPEQPTPNSTNSSCPSHNT 695

  Fly   450 RTVQNSKLPE---------MEGMEYKCDRIN---------------------------------- 471
            .|:..||:..         ....||.....|
  Fly   696 ATIAKSKINSNILSTCTSLTSTNEYCFTNTNTTTASTPSAPPSATPSSAPALASATPPSTCTPSF 760

  Fly   472 --------------LCLKSPELFLRYVLDIIKNLDEKELSTQDKRRRFTQASGRGQTKKNARSRL 522
                          .|..|.|.:         :.|.|..||..            .|..||
  Fly   761 TQIAPSATAPATSTTCTTSAEFY---------DGDHKTTSTST------------TTTSNA---- 800

  Fly   523 RLASNAAYTTGTGWRSNRKINL---------------NDIYPIDPANNECDVRVKIADLGNACYF 572
              .|:|..||.|...:..|:|:               |:.|.|....:..:|||||||||||||.
  Fly   801 --ISSATTTTATTTTAIAKLNVHANAIPSQNQSQSSQNNTYTIQSLIDNSNVRVKIADLGNACYD 863

  Fly   573 HHHFTDDIQTKEYRALEVILGAGYCETADIWSVACLLWELATGTYLFDTHSKRGKYNLDEVHIAK 637
            :||||:||||::||::||:|||.|..||||||.|||.:|||||.||||.|:.. .|:.||.|:|.
  Fly   864 YHHFTEDIQTRQYRSIEVLLGAPYNYTADIWSTACLAFELATGDYLFDPHAGE-SYSRDEDHLAH 927

  Fly   638 IVETCGRIPWYLIRKGKHSRNFINSAGKLCNIETLKPLKLANILIRWYGWRTRQSTEFVNFLMPM 702
            |||..|.||..:|.:|||...:..|.|.|.||..|||..|.|:|:..|.|...::.:|.:||:||
  Fly   928 IVELLGSIPQSVIFRGKHGLKYFTSYGSLRNITKLKPWSLMNVLVEKYDWDPVEAKKFSDFLLPM 992

  Fly   703 LQTNPLSRISASKALESHYL 722
            |:.||:.|.||::.|:..:|
  Fly   993 LEYNPVIRASAAECLQHPWL 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	213/707 (30%)
Srpk79D	NP_001246881.1	STKc_SRPK	336..>504	CDD:271038	78/167 (47%)
		S_TKc	347..>492	CDD:214567	68/144 (47%)
		STKc_SRPK	<844..1012	CDD:271038	88/168 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I930
eggNOG	1	0.900	-	-		E1_KOG1290
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2039
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	P	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.770