DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8565 and madd-3

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_001368709.1	Gene:	madd-3 / 3565068	WormBaseID:	WBGene00006517	Length:	890	Species:	Caenorhabditis elegans

Alignment Length:	761	Identity:	142/761 - (18%)
Similarity:	240/761 - (31%)	Gaps:	307/761 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KRAFQEKI---RKQMESCGVTQMGN-----------------ASTQQSNVPMDVDADMGRK---- 61
            ||..::|:   :|::...||...|:                 .:|..:|.....|....:|
Worm   370 KRLIEKKLSLRKKKLSGEGVPPAGSMLTGSKSGVEIGLSSNLTTTNNNNNKEQTDEQRAKKTVNA 434

  Fly    62 ----MSEDGMTDTSNTVKQPSCSKDQKQLSRKQKPSP-SYNHQEQIEQ-------RAKRPKICKK 114
                .|....:..:.||..|:.:...|:....|.|.| |...|..|.|       .||..||.
Worm   435 VAAAFSTQAGSGNATTVDDPASTTTSKENPAAQPPKPKSAAVQNLISQLQLPASVSAKVDKII-- 497

  Fly   115 RCKQKRRMPSSLSDDGIAGRKPAKINKYSELSYGSESSMPFEMKQQSNDNQNNNDNAEGSGFDRQ 179
            .|..|.|.||.      :|.:.::          :...:|..:..|...:|::.|
Worm   498 ACGDKARKPSR------SGLQASQ----------ARPKVPEIVSSQRTQHQDDKD---------- 536

  Fly   180 ESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVSKSAQVYKETG 244
                     |:...:.||..:||:.::..||.|.|..|....|:..|.:.|:|:.|:...|:|..
Worm   537 ---------GHLIYSKGDFILNRFTIYDTLGEGTFGKVVRVNDSLSDTFMALKIIKNVSKYREAA 592

  Fly   245 IDEIMLFSQMSLHDQHKYRSHVVGFYDFFEITGPHGRHICLVLEVLGDNLLKVIERCFYKGMPIS 309
            ..|:.:..:::..|..| ::.|:....:|:..|    ||||:.:::|.::...::...||..|:.
Worm   593 KLEVKVLQKLAEKDPEK-KNWVIHMGSYFDYNG----HICLLFDLMGSSIFDFLKANHYKPYPME 652

  Fly   310 NIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANEGKLSPSSK 374
            ....|..|:...:||||:. .:.||||||||:|...:
Worm   653 QTLHITWQLCNAVKFLHDN-KLTHTDLKPENILFVDS---------------------------- 688

  Fly   375 MTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAERGLIEPITAAMAVSDNLPFIPFGFD 439

Worm   689 ----------------------------------------------------------------- 688

  Fly   440 GFMMMSDADCRTVQNSKLPEMEGMEYKCDRINLCLKSPELFLRYVLDIIKNLDEKELSTQDKRRR 504
                                                      ||...::   |:|.|
Worm   689 ------------------------------------------RYTTKLV---DKKPL-------- 700

  Fly   505 FTQASGRGQTKKNARSRLRLASNAAYTTGTGWRSNRKINLNDIYPIDPANNECDVRVKIADLGNA 569
                                  ...::|                           .|::.|.|:|
Worm   701 ----------------------RVLHST---------------------------HVRLIDFGSA 716

  Fly   570 CYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSVACLLWELATGTYLFDTHSKRGKYNLDEVH 634
            .:.|.|.:..:.|:.|||.||||..|:.:..|:||:.|:|:||.||..||.||..|       .|
Worm   717 TFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHENR-------EH 774

  Fly   635 IAKIVETCGRIPWYLIRKGKHSRNF------------INSAGKLCNI-ETLKPLKLANILIRWYG 686
            :|.:....|.||   :|..|.:..|            :|::.....: :..|||:      |...
Worm   775 LAMMERVLGDIP---LRMAKRTNTFRTKFFINGRLDWVNTSADAAYVRDNCKPLR------RSMS 830

  Fly   687 WRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYLC----NIALP 728
            ....:..|....:..||...||:|:...:||:..|..    |:.:|
Worm   831 CTDPEHVELFELIENMLMFEPLARMKLPEALQHRYFNRLPENLKIP 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	101/542 (19%)
madd-3	NP_001368709.1	PHA03247	<73..364	CDD:223021
madd-3	NP_001368709.1	PKc_CLK	538..866	CDD:271036	101/544 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920