DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8565 and Srpk2

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_038963154.1	Gene:	Srpk2 / 296753	RGDID:	1305107	Length:	749	Species:	Rattus norvegicus

Alignment Length:	794	Identity:	251/794 - (31%)
Similarity:	345/794 - (43%)	Gaps:	220/794 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 IEQRAKRPKIC---------------KKRCKQKRRMPSSLSDDGIAGRKPAKINKYSELSYGSES 151
            :|:||.||..|               :|:.|||..:..|::               ||.|..||.
  Rat     1 MERRAARPAGCWPFRPESGGRKERNIRKKIKQKIELLMSVN---------------SEKSSSSER 50

  Fly   152 SMPFEMKQQSND------------------NQNNNDNAEGSGFDRQESANEYVIGGYHPVAIGDV 198
            ..|    ||...                  .....:...||..:.||...:|..||||||.|||:
  Rat    51 PEP----QQKAPLVPPPPPPPPPPPLPDPVPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDL 111

  Fly   199 FVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVSKSAQVYKETGIDEIMLFSQMSLHD-QHKY 262
            |..||||.:|||||||||||||:|.|..|:.|:||.||||.|.||.:|||.|...:...| ....
  Rat   112 FNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPN 176

  Fly   263 RSHVVGFYDFFEITGPHGRHICLVLEVLGDNLLKVIERCFYKGMPISNIKQIAQQVLTGLKFLHE 327
            :..||...|.|:|:|.:|.|:|:|.||||.:|||.|.:..|:|:|:..:|.|.:|||.||.:||.
  Rat   177 KDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHS 241

  Fly   328 ECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANEGKLS-----------PSSKMTKTAKR 381
            :|.|||||:||||:|:..:...||.....|.| :.||.....|           |..|::|..|:
  Rat   242 KCKIIHTDIKPENILMCVDGAYVRRMAAEATE-WQKAGAPPPSGSAVSTAPQQKPIGKISKNKKK 305

  Fly   382 RMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAERGLIEPITAAMAVSDNLPFIPFGFDGFMMMSD 446
            :::.|.|:.....:.     |.|.||:|...|||.::|..|.:...|..              .|
  Rat   306 KLKKKQKRQAELLEK-----RLQEIEELEREAERKILEENTTSAEASSE--------------QD 351

  Fly   447 ADCRTVQNSKLPEME---------------------------------GMEYKCDRIN-LCLKSP 477
            .:|:.....|..|:|                                 .:|.:.:.|: ..::||
  Rat   352 GECQPEVKLKEAELEDTTEEETAKDNGEVEDQEEKEDTEKENTEKDEDDVEQELENIDPTWMESP 416

  Fly   478 E--------LFL-------------------RYVLDIIKNLDEKELST----------------- 498
            :        |||                   .|      ||||....:
  Rat   417 KANGHIENGLFLLEQQLEDEEDEEDDCANPEEY------NLDEPNAESDYTYSSSYEQFNGELPN 475

  Fly   499 -QDKRRRF----------------TQASGRGQTKKNARSRLRLASNAAYTTGTGWRSNRKINLND 546
             |.|...|                ..:.|...|:....|..|..|.....:.||.....|....|
  Rat   476 GQPKSPEFPTPLFSGPLEPVASDSVLSEGSPLTEPEESSPSRDRSRTVSASSTGDLPKTKTRAAD 540

  Fly   547 --IYPIDPANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSVACLL 609
              :.|:||.|.: .:|||||||||||:.|.|||:||||::||::||::||||...|||||.||:.
  Rat   541 LLVNPLDPQNAD-KIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMA 604

  Fly   610 WELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFIN------------- 661
            :|||||.|||:.||.. .|:.||.|||.|:|..|.||.:....||:||.|.|
  Rat   605 FELATGDYLFEPHSGE-DYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRDHIALIIELLG 668

  Fly   662 ------------------SAGKLCNIETLKPLKLANILIRWYGWRTRQSTEFVNFLMPMLQTNPL 708
                              ..|:|.:|..|||..|.::|:..|||....:.:|.:||:|||:..|.
  Rat   669 KVPRKYAMLGKYSKEFFTRKGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPE 733

  Fly   709 SRISASKALESHYL 722
            .|.||.:.|...:|
  Rat   734 KRASAGECLRHPWL 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	222/669 (33%)
Srpk2	XP_038963154.1	PKc_like	103..>291	CDD:419665	91/188 (48%)
		2A1904	<338..417	CDD:273344	11/92 (12%)
		PKc_like	<538..747	CDD:419665	88/210 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336812
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46465
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.610