DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8565 and Srpk3

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_006229620.1	Gene:	Srpk3 / 293854	RGDID:	727856	Length:	593	Species:	Rattus norvegicus

Alignment Length:	635	Identity:	235/635 - (37%)
Similarity:	315/635 - (49%)	Gaps:	82/635 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 CKKRCKQKRRMPSSLSDDGIAGRKPAKINKYSELSYGSESS-------MPFEMKQQSNDNQNNND 169
            |.:......||  |.|..|..|......:..|:.|.|.|||       .|.....|
  Rat    15 CTRALGCDTRM--SASAGGSGGMDCGGSSSSSQTSCGPESSSSELAPATPAPRLLQ--------- 68

  Fly   170 NAEGSGFDRQESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVS 234
            ...||..:.||...:|..|||:||.|||:|..||||.:|||||||||||||:|.|..|:.|:||.
  Rat    69 GLLGSDDEEQEDPKDYCKGGYYPVKIGDLFNGRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVV 133

  Fly   235 KSAQVYKETGIDEIMLFSQMSLHD-QHKYRSHVVGFYDFFEITGPHG--RHICLVLEVLGDNLLK 296
            |||..|.||.:|||.|...:...| ....|..:|...|.|.|:|.:|  ..:|:||||||..|||
  Rat   134 KSAGHYTETAVDEIKLLKCVRDSDPSDPKRETIVQLIDDFRISGVNGVRPDVCMVLEVLGHQLLK 198

  Fly   297 VIERCFYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVY 361
            .|.:..|:|:|:..:|.|.:|||.||.:||.:|.|||||:||||:||...:..:|   :.|.|..
  Rat   199 WIIKSNYQGLPVPCVKSIVRQVLHGLDYLHTKCKIIHTDIKPENILLCVGDAYIR---RLAAEAT 260

  Fly   362 LKANEGKLSPSSKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAER----GLIEPIT 422
            .....|...||.....||.:.:....|    ..||.|:.:||:..:....|.||    ..:|.:.
  Rat   261 EWQQSGAQPPSRSTVSTAPQEVLQTGK----LSKNKRKKMRRKRKQQKRLLEERLRDLQRLEAME 321

  Fly   423 AAMAVSDNLPFIPFGFDGFMMMSDADCRTVQNSKLPEMEGMEYKCDRI--NLCLKSPELFLRYVL 485
            ||                 :...|:..|..|.|......|...:..|.  :....||
  Rat   322 AA-----------------VQTEDSSSRLEQGSGSTSSSGCHPEGTRAGPSPASSSP-------- 361

  Fly   486 DIIKNLDEKELSTQDKRRRFTQASG-RGQTKKNAR-SRLRLASNAAYTTG-----TGW-RSNRKI 542
              :....|:.||..      :|.|| .|.....|. |.|..:||...|.|     |.: .||..:
  Rat   362 --VPTGGERSLSPS------SQTSGFSGSLFSTASCSVLSGSSNQRETGGLLSPSTPFGASNLLV 418

  Fly   543 NLNDIYPIDPANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSVAC 607
            |     |::|.|.: .:::|||||||||:.|.|||:||||::|||:||::||.|...|||||.||
  Rat   419 N-----PLEPQNAD-KIKIKIADLGNACWVHKHFTEDIQTRQYRAVEVLIGAEYGPPADIWSTAC 477

  Fly   608 LLWELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFINSAGKLCNIETL 672
            :.:|||||.|||:.||.. .|:.||.|||.|||..|.||......|::||.|.|..|:|.:|..|
  Rat   478 MAFELATGDYLFEPHSGE-DYSRDEDHIAHIVELLGDIPPAFALSGRYSREFFNRRGELRHIHNL 541

  Fly   673 KPLKLANILIRWYGWRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYL 722
            |...|..:|:..|.|...|:|:|..||:||::..|..|.||:..|:..:|
  Rat   542 KHWGLYEVLMEKYEWPLEQATQFSAFLLPMMEYIPEKRASAADCLQHPWL 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	211/546 (39%)
Srpk3	XP_006229620.1	PKc_like	91..591	CDD:304357	211/546 (39%)
Srpk3	XP_006229620.1	S_TKc	102..591	CDD:214567	204/535 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336814
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46465
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750