DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8565 and dsk1

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	NP_595327.1	Gene:	dsk1 / 2539847	PomBaseID:	SPBC530.14c	Length:	544	Species:	Schizosaccharomyces pombe

Alignment Length:	584	Identity:	195/584 - (33%)
Similarity:	290/584 - (49%)	Gaps:	102/584 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 NQNNNDNAEGSGFD-------RQESANEYVIGGYHPVAIGDVFVN-RYHVFKKLGWGHFSTVWLC 220
            |.|...|||..|..       .:|:|.:|..||||||.||:.|.: ||.|.:||||||||||||.
pombe    34 NVNKKVNAEVDGKSMVEKVKTHEENAEDYHYGGYHPVYIGEEFHHRRYVVERKLGWGHFSTVWLA 98

  Fly   221 YDTQMDRYCAVKVSKSAQVYKETGIDEIMLFSQMSLHDQ-HKYRSHVVGFYDFFEITGPHGRHIC 284
            ||....|..|:||.:||:.|:||.||||.:..::...|: |..:.|::...|:|...||:|.|:|
pombe    99 YDRAAKRRVALKVVRSAEHYRETSIDEIRILQKIREGDEKHLGKKHIISLLDYFVHRGPNGAHVC 163

  Fly   285 LVLEVLGDNLLKVIERCFYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVS 349
            :|.||||:|||.:|:...::|:|:..:||||.|:|..|.:||.|||||||||||||||:..::.:
pombe   164 MVFEVLGENLLSLIQSYGHRGVPVGIVKQIAYQLLIALDYLHRECGIIHTDLKPENVLICIDQDA 228

  Fly   350 VRTEIKTAIEVYLKANEGKLSPSSKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLLYLAE 414
            ::         :::|.....||:|. |.::|.|............|      |.|.:::.....:
pombe   229 LQ---------HIEAPATTSSPTSN-TSSSKTRNNTGYTAKAPIIK------RGQSVDNSAQERK 277

  Fly   415 RGLIEPITAAMAVSDNLPFIPFGFDGFMMMSDADCRTVQNSKLPEMEGMEYKCDRINLCLKSPEL 479
            .....|...:......:|..||              |...|:.|.:||.
pombe   278 TFAKNPTKNSKPAGQVIPSSPF--------------TSTLSRFPSLEGA---------------- 312

  Fly   480 FLRYVLDIIKNLDEKELSTQDKRRRFTQASGRGQTKKNARSRLRLASNAAYTTGTGWRSNRKINL 544
                         ..|:|.:|.:            |.|:.      .|:.:::|    .|..|
pombe   313 -------------VSEISLRDSQ------------KHNSH------PNSPFSSG----DNSLI-- 340

  Fly   545 NDIYPIDPANNECD----VRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSV 605
                 :|..|...:    :.||||||||||:...|||:|:||::||:.|||||..:..:||.||.
pombe   341 -----LDGVNGSQEPVPKITVKIADLGNACWTRKHFTNDVQTRQYRSPEVILGCRWGASADCWSF 400

  Fly   606 ACLLWELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFINSAGKLCNIE 670
            ||:::||.||.||||..: ...|:.::.|||:|:|.....|..:...|||||:..|..|:|.||.
pombe   401 ACIIFELLTGDYLFDPRN-GNSYSKEDDHIAQIIELLVNYPKQMALSGKHSRDLFNRRGELRNIH 464

  Fly   671 TLKPLKLANILIRWYGWRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYLCNIALPGIDIDS 734
            .||...|.::|.:.|.:....:.:..:||.|||..:|..|.:|.....|.:|..:|.|...|::
pombe   465 KLKFWPLKDVLEQKYHFSAELAQQISDFLSPMLCFDPAKRTNAGYMSNSPWLREVADPTFKIET 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	178/535 (33%)
dsk1	NP_595327.1	STKc_SRPK	69..516	CDD:271038	178/535 (33%)
dsk1	NP_595327.1	S_TKc	81..516	CDD:214567	172/523 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1290
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	319	1.000	Inparanoid score	I552
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100556
Panther	1	1.100	-	-	O	PTHR24055
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.820