Protein Alignment CG8565 and Mapk10

DIOPT Version :10

• Sequence 1: NP_573080.1
• Gene: CG8565 / 32538
• FlyBaseID: FBgn0030697
• Length: 790
• Species: Drosophila melanogaster
• Sequence 2: NP_001305119.1
• Gene: Mapk10 / 25272
• RGDID: 3663
• Length: 478
• Species: Rattus norvegicus
• Alignment Length: 648
• Identity: 121/648 - (18%)
• Similarity: 201/648 - (31%)
• Gaps: 298/648 - (45%)

  Fly   175 GFDR----QESANEY------VIGGYHPVAIGD---VFVNRYHVFKKLGWGHFSTVWLCYDTQMD 226
            |||:    ...|..|      |...::.|.:||   ..:.||...|.:|.|....|...||..:|
  Rat    23 GFDKHVDVSSVAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLD 87

  Fly   227 RYCAV-KVSK--SAQVYKETGIDEIMLFSQMSLHDQHKYRSHVVGFYDFF--EITGPHGRHICLV 286
            |..|: |:|:  ..|.:.:....|::|...::    ||   :::...:.|  :.|....:.:.||
  Rat    88 RNVAIKKLSRPFQNQTHAKRAYRELVLMKCVN----HK---NIISLLNVFTPQKTLEEFQDVYLV 145

  Fly   287 LEVLGDNLLKVI------ERCFYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLAS 345
            :|::..||.:||      ||..|          :..|:|.|:|.|| ..||||.||||.|:::.|
  Rat   146 MELMDANLCQVIQMELDHERMSY----------LLYQMLCGIKHLH-SAGIIHRDLKPSNIVVKS 199

  Fly   346 NEVSVRTEIKTAIEVYLKANEGKLSPSSKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIEDLL 410
                                                                             
  Rat   200 ----------------------------------------------------------------- 199

  Fly   411 YLAERGLIEPITAAMAVSDNLPFIPFGFDGFMMMSDADCRTVQNSKLPEMEGMEYKCDRINLCLK 475
                                                 ||                       .||
  Rat   200 -------------------------------------DC-----------------------TLK 204

  Fly   476 SPELFLRYVLDIIKNLDEKELSTQDKRRRFTQASGRGQTKKNARSRLRLASNAAYTTGTGWRSNR 540
                    :||.                                       ..|.|.||.:.
  Rat   205 --------ILDF---------------------------------------GLARTAGTSFM--- 219

  Fly   541 KINLNDIYPIDPANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYCETADIWSV 605
                                               .|..:.|:.|||.|||||.||.|..|||||
  Rat   220 -----------------------------------MTPYVVTRYYRAPEVILGMGYKENVDIWSV 249

  Fly   606 ACLLWELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGR-IPWYLIRKGKHSRNFINSAGKLCNI 669
            .|::.|:.....||.     |:..:|:.:  |::|..|. .|.::.:.....||::.:..|...:
  Rat   250 GCIMGEMVRHKILFP-----GRDYIDQWN--KVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGL 307

  Fly   670 -------ETLKPLKLANILIRWYGWRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYLCNIAL 727
                   ::|.|....:..::        :::..:.|..||..:|..|||...||:..|: |:..
  Rat   308 TFPKLFPDSLFPADSEHNKLK--------ASQARDLLSKMLVIDPAKRISVDDALQHPYI-NVWY 363

  Fly   728 PGIDIDS---YYY--------YSVREIKDCTHTKSERNSDE----------DSSSCSSIDSSE 769
            ...::::   ..|        :::.|.|:..: |...||:|          .|.|.::::|||
  Rat   364 DPAEVEAPPPQIYDKQLDEREHTIEEWKELIY-KEVMNSEEKTKNGVVKGQPSPSGAAVNSSE 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	Protein Kinases, catalytic domain	192..722	CDD:473864	101/551 (18%)
Mapk10	NP_001305119.1	STKc_JNK	63..398	CDD:270840	104/579 (18%)