Protein Alignment CG8565 and spk-1

DIOPT Version :10

• Sequence 1: NP_573080.1
• Gene: CG8565 / 32538
• FlyBaseID: FBgn0030697
• Length: 790
• Species: Drosophila melanogaster
• Sequence 2: NP_499080.3
• Gene: spk-1 / 176328
• WormBaseID: WBGene00004980
• Length: 1003
• Species: Caenorhabditis elegans
• Alignment Length: 864
• Identity: 267/864 - (30%)
• Similarity: 393/864 - (45%)
• Gaps: 215/864 - (24%)

  Fly    25 QEKIRKQMESCGVTQMGNASTQQSNVPMDVDADMGRKMSEDGMTDTSNTVKQPSC----SKDQKQ 85
            :|.:..|.:|..|    |.:|::|     :|:....:..|   .:.|.|....||    .|::|.
 Worm   204 EEDVESQDDSFHV----NDATEES-----IDSVSSIESQE---AEESATEDLASCHSNDDKNEKD 256

  Fly    86 LSRKQKPSPSYNHQEQIEQRAKRPKICKKRCKQKRRMPSSLS---------DDG----------- 130
            :...:..| .|::. .:|.|:     .|:..:.:..:.||:|         |||
 Worm   257 VLVDEDTS-KYDNL-PVEMRS-----AKEGEESEGTIDSSVSSSTSSSSTGDDGDDSATSYDSED 314

  Fly   131 ------------------IAGRKPAKI---NKYSELSYGSESSMPFEMKQQSNDN---------- 164
                              |:..:|:.|   ||.:|::...|......:....:|:
 Worm   315 IEIQMFEYDLGTACASASISIPRPSIIPRNNKKTEVNANEERLDDLSVSPGRSDSPGGGGGGHSD 379

  Fly   165 --QNNNDNAE--GSGFDRQESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQM 225
              |:..|..|  ||..:.||...:|..||||||.|||||..||||.:||||||||||||.:|||.
 Worm   380 SFQDPMDPGEQLGSDDEEQEDPRDYKRGGYHPVNIGDVFNARYHVIRKLGWGHFSTVWLAWDTQD 444

  Fly   226 DRYCAVKVSKSAQVYKETGIDEIMLFSQMSLHDQHKYRSH-VVGFYDFFEITGPHGRHICLVLEV 289
            .|:.|:|:.|||:.|.|..:|||.|...:...|.:....| ||...|.|.:||.:|:|:.:|.||
 Worm   445 KRFVAMKIVKSAEHYTEAALDEIKLLLSVRSADPNDIGCHKVVQLLDEFTVTGINGQHVAMVFEV 509

  Fly   290 LGDNLLKVIERCFYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEI 354
            ||.||||:|.|..|:|:.:..:::|.:|||..|.::||:|||||||:||||||:..:    |.||
 Worm   510 LGCNLLKLIIRSNYRGLHLEQVRKICRQVLEALGYMHEKCGIIHTDIKPENVLITMS----REEI 570

  Fly   355 KTAIE--VYLKANEGKLSPSS--------------KMTKTAKRRMQAKSKKVISFFKNHRRMLRR 403
            |...:  |..:....|:|.|:              .|||..|::|:.|:||            :|
 Worm   571 KIMAQHAVVARKMNMKMSGSAVSTAPDHLVKMAQENMTKNKKKKMKKKAKK------------QR 623

  Fly   404 QGIEDLLYLAERGLIEPITAAMAVSDNLPFIPFGFDGFMMMSDADCRTVQNSKLPEMEG------ 462
            :.:|               |.:|          |.:|..|  ||:......:..||:|.
 Worm   624 EKLE---------------AELA----------GLEGLKM--DANGLQEAYNNAPELENFNASQV 661

  Fly   463 ----MEYKCDRIN-------LCLKSPELFLRYVLDIIKNLDEKELSTQDKRRRFTQASGRGQTKK 516
                ||   |.:|       :.::||:.|.|..|          ....|...:|..
 Worm   662 EDVTME---DTVNENGNRNKVEIRSPDRFDRTTL----------TPFSDPESKFGD--------- 704

  Fly   517 NARSRLRLAS-NAAYTTGTGWRSNRKINLNDIYPIDPANNE-----CDVRVKIADLGNACYFHHH 575
                   ||| :|.|.:.    ...::....|.|..|....     ||:.||||||||||:.:||
 Worm   705 -------LASPSAEYLSS----PMSQLPPGGILPAPPVGPNIGDPYCDIDVKIADLGNACWVNHH 758

  Fly   576 FTDDIQTKEYRALEVILGAGYCETADIWSVACLLWELATGTYLFDTHSKRGKYNLDEVHIAKIVE 640
            :||||||::||||||::|:||...|||||.||:.:|||||.|||:.| :...|:.||.|:|.|.|
 Worm   759 YTDDIQTRQYRALEVLIGSGYGPPADIWSTACMAFELATGDYLFEPH-QGDNYSRDEDHLAHISE 822

  Fly   641 TCGRIPWYLIRKGKHSRNFINSAGKLCNIETLKPLKLANILIRWYGWRTRQSTEFVNFLMPMLQT 705
            ..|.||..:.:||||.|.|.:..|.|.:|..|||..|..:|.:.|.|....:.:|.:||.|||..
 Worm   823 LLGAIPPSIYKKGKHWREFFHKNGHLLHIHQLKPWSLYEVLRQKYEWSHEDAQQFESFLRPMLDF 887

  Fly   706 NPLSRISASKALESHYLCNIA--LPGID------------------IDSYYYYSVREIKDCTHTK 750
            :...|.:|..||:..:|....  .|..|                  .|...:..|...::.:.:.
 Worm   888 DQEKRSTAKIALKHPFLLPFGGRAPKSDCPPELLSKMFPDGLIPEPFDGNEHQEVYRDENDSRSA 952

  Fly   751 SERNSDEDSSSCSSIDSSE 769
            |||:::..|:..|..|..|
 Worm   953 SERSANSRSAGGSDDDDEE 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	Protein Kinases, catalytic domain	192..722	CDD:473864	209/569 (37%)
spk-1	NP_499080.3	STKc_SRPK	411..904	CDD:271038	209/569 (37%)