DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8565 and srpk2

DIOPT Version :9

Sequence 1:	NP_573080.1	Gene:	CG8565 / 32538	FlyBaseID:	FBgn0030697	Length:	790	Species:	Drosophila melanogaster
Sequence 2:	XP_021326235.1	Gene:	srpk2 / 100333293	ZFINID:	ZDB-GENE-131105-1	Length:	817	Species:	Danio rerio

Alignment Length:	775	Identity:	239/775 - (30%)
Similarity:	328/775 - (42%)	Gaps:	251/775 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 GSGFDRQESANEYVIGGYHPVAIGDVFVNRYHVFKKLGWGHFSTVWLCYDTQMDRYCAVKVSKSA 237
            ||..:.||...:|..||||||.|||:|.:.|||.:|||||||||||||:|.|..|:.|:||.|||
Zfish    67 GSDDEEQEDPADYCKGGYHPVKIGDLFNSHYHVIRKLGWGHFSTVWLCWDIQGKRFVAMKVVKSA 131

  Fly   238 QVYKETGIDEIMLFSQMSLHD-QHKYRSHVVGFYDFFEITGPHGRHICLVLEVLGDNLLKVIERC 301
            |.|.||.:|||.|...:...| :...:..||...|.|:|:|.:|.|:|:|.||||.:|||.|.:.
Zfish   132 QHYTETALDEIKLLRCVRETDPEDPNKDMVVQLIDDFKISGVNGIHVCMVFEVLGHHLLKWIIKS 196

  Fly   302 FYKGMPISNIKQIAQQVLTGLKFLHEECGIIHTDLKPENVLLASNEVSVRTEIKTAIEVYLKANE 366
            .|:|:|:..:|.|.:|||.||.:||.:|.|||||:||||:|:..::..||   :.|:|.......
Zfish   197 NYQGLPLPCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAFVR---RMAVEATEWQKA 258

  Fly   367 GKLSPS-------------SKMTKTAKRRMQAKSKKVISFFKNHRRMLRRQGIE--------DLL 410
            |...||             .|::|..|::|:.|.|:.....:  ||||..:.:|        |..
Zfish   259 GAPPPSGSAVSTAPQLKQVGKISKNKKKKMKKKQKRQAELLE--RRMLEIEALEREAEKQRADGE 321

  Fly   411 YLAERG-------------------------------LIEPITAAMAVSD--------------- 429
            .:||.|                               ..||....:..||
Zfish   322 TIAEHGPTLADSEEDEEEEEDEEEEEKQRPVRLTNHTCAEPEQPEVEDSDDGEESHTHTHTPTHT 386

  Fly   430 ----------------------------NLP-FIPFG----------------FDGFMMMSDADC 449
                                        :.| ..|.|                .||     ..|.
Zfish   387 PTHTATHTPTHTPTETPTQTPTHTPTHAHTPTHTPLGRTDTPQEPERSGGAEELDG-----SGDG 446

  Fly   450 RTVQNSKLPEMEGME-------------------------------------------------- 464
            |..:..|..|:|..|
Zfish   447 RQEEEEKAEEVEKAEEVEEETAAAPSESTEEETRQCVKEDEQTKHTRDTQDEEEEEEEEDDEEDE 511

  Fly   465 --------------------YKCDRINLCLK--SPELFLRYVLDIIKNLDEKELSTQDK------ 501
                                :.|..:..|:.  :|.|....|        |.|:||.|:
Zfish   512 EDEEEEEEEEEQSTAAKTNGHVCVCVQECVSPAAPTLLCPLV--------ESEISTTDRDASDAS 568

  Fly   502 ---------------RRRFT-----------------QASGRGQTKKNARSRLRLASNAAYTTGT 534
                           |.|.|                 |...:|..:.:.|||      ...::.|
Zfish   569 YELFNGDTSSLSNGARHRGTTPRFPELPLDPDPTHTLQDQAQGPDRHSDRSR------TVSSSST 627

  Fly   535 GWRSNRKINLND--IYPIDPANNECDVRVKIADLGNACYFHHHFTDDIQTKEYRALEVILGAGYC 597
            |.....:|...|  :.|:||.|.|. :|||||||||||:.|.|||:||||::||::||::||||.
Zfish   628 GDNPKARIRAADLLVNPLDPRNAEA-LRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYS 691

  Fly   598 ETADIWSVACLLWELATGTYLFDTHSKRGKYNLDEVHIAKIVETCGRIPWYLIRKGKHSRNFINS 662
            ..|||||.||:.:|||||.|||:.||.. .|:.||.|||.|:|..|.||.:....||:||.|.|.
Zfish   692 TPADIWSTACMAFELATGDYLFEPHSGE-DYSRDEDHIAHIIELLGCIPRHFALSGKYSREFFNR 755

  Fly   663 AGKLCNIETLKPLKLANILIRWYGWRTRQSTEFVNFLMPMLQTNPLSRISASKALESHYL 722
            .|:|.:|..|||..|.::|:..|||...::..|.:||:|||:..|..|.|||:.|...:|
Zfish   756 RGELRHITKLKPWSLFDVLVEKYGWAAEEAGHFTHFLLPMLEMVPEKRASASECLHHPWL 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8565	NP_573080.1	PKc_like	192..722	CDD:304357	229/754 (30%)
srpk2	XP_021326235.1	PKc_like	84..>274	CDD:328722	90/192 (47%)
srpk2	XP_021326235.1	PKc_like	<637..815	CDD:328722	90/179 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290680at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010