Protein Alignment Chc and CHC1

DIOPT Version :10

• Sequence 1: NP_477042.1
• Gene: Chc / 32537
• FlyBaseID: FBgn0000319
• Length: 1678
• Species: Drosophila melanogaster
• Sequence 2: NP_011309.1
• Gene: CHC1 / 852666
• SGDID: S000003174
• Length: 1653
• Species: Saccharomyces cerevisiae
• Alignment Length: 1657
• Identity: 808/1657 - (48%)
• Similarity: 1158/1657 - (69%)
• Gaps: 19/1657 - (1%)

  Fly     5 LPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRPISAD 69
            |||.|.|.:.|.::||:.....|.:.|.|||.|:.|||..:.|..|.|:|:......||:.:..|
Yeast     4 LPIEFTELVDLMSLGISPQFLDFRSTTFESDHFVTVRETKDGTNSVAIVDLAKGNEVTRKNMGGD 68

  Fly    70 SAIMNPASKVIALKAQKTL-QIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFHWSM- 132
            ||||:|:..||:::|..|: ||||:|.|||:|:.|::|.|:||:|:|..||..||..|:...::
Yeast    69 SAIMHPSQMVISVRANGTIVQIFNLETKSKLKSFTLDEPVIFWRWLSETTLGFVTARSILTSNVF 133

  Fly   133 EG--DSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAIE 195
            :|  ::.||.:..||::||..||||:..|.:..|..:|||.....|:||.:||:|.:|.:||||:
Yeast   134 DGNVNAKPQLLTLRHANLNNTQIINFVANKNLDWFAVVGILQENGRIAGRIQLFSKQRNISQAID 198

  Fly   196 GHAASFATFKIDAN-KEPTTLFCFAVRTAT--GGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQ 257
            ||.|.|....::.| ..|..:|....|.||  .|:|.|||:....:....:.|:..|:||||:|.
Yeast   199 GHVAIFTNILLEGNGSTPVQVFVTGNRNATTGAGELRIIEIDHDASLPSQYQKETTDIFFPPDAT 263

  Fly   258 NDFPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKG 322
            ||||:|:|||.||..|||:||||:||||::||.|.:::|||:|:::|..||:....||..:|:||
Yeast   264 NDFPIAVQVSEKYGIIYLLTKYGFIHLYELETGTNLFVNRITAESVFTAAPYNHENGIACINKKG 328

  Fly   323 QVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALA 387
            |||:|.:...||:|||...|.|..|||.:|.|..|.||:|||.::|..|.....|..||||||.:
Yeast   329 QVLAVEISTSQIVPYILNKLSNVALALIVATRGGLPGADDLFQKQFESLLLQNDYQNAAKVAASS 393

  Fly   388 PKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKW 452
            ..  ||...||.|.:.:|.|.|:.:|.|| ||..|||:|||||.|::||.||||.|.:|||.|||
Yeast   394 TS--LRNQNTINRLKNIQAPPGAISPILL-YFSTLLDKGKLNKEETIELARPVLQQDRKQLFEKW 455

  Fly   453 LKEEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVF 517
            |||:||||||||||:||..|.||||:.||||....|||.|.||..||:||:.|.:||.|.|:::.
Yeast   456 LKEDKLECSEELGDIVKPFDTTLALACYLRAGAHAKVISCLAELQQFEKIIPYCQKVGYQPNFLV 520

  Fly   518 LLRSVMRSNPEQGAGFASMLVAEEEPLA--DINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGA 580
            |:.|::||:|::.:.||..|:...|..:  ||.:|.|:|...:.:||.|:.||||||.:.|.:|.
Yeast   521 LISSLIRSSPDRASEFAVSLLQNPETASQIDIEKIADLFFSQNHIQQGTSLLLDALKGDTPDQGH 585

  Fly   581 LQTRLLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTH 645
            ||||:||:||:.|||||||||||.:|:|||:..||.|.|||||.|||||:|||:.||||.||||:
Yeast   586 LQTRVLEVNLLHAPQVADAILGNNIFSHYDKPTIASLSEKAGLYQRALENYTDIKDIKRCVVHTN 650

  Fly   646 MLNAEWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYD 710
            .|..:|||.:||.|:||.||.||||::..|::.|:|..||:|||:.:.:....||.|||.:.:.:
Yeast   651 ALPIDWLVGYFGKLNVEQSLACLKALMDNNIQANIQTVVQVATKFSDLIGPSTLIKLFEDYNATE 715

  Fly   711 GLFYFLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPL 775
            ||:|:|:|:||.::|.:|.:|||:||.|..|.:|:|||.:::|.|:|||||||||:|.|.|||||
Yeast   716 GLYYYLASLVNLTEDKDVVYKYIEAAAKMKQYREIERIVKDNNVYDPERVKNFLKDANLEDQLPL 780

  Fly   776 IIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQ 840
            :||||||||||:::||||::...|:||.|||:||||:...|||.|||:||.|..|::|:..|.||
Yeast   781 VIVCDRFDFVHEMILYLYKSQNLKFIETYVQQVNPSKTAQVVGALLDMDCDEAFIQSLLQSVLGQ 845

  Fly   841 FSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRV 905
            ...:||..|||||||||:|||:||..:.:|..:.|.:||||||||||||:||::||||..||:..
Yeast   846 VPINELTTEVEKRNRLKILLPFLEQSLSQGIQDQAVYNALAKIYIDSNNSPEKFLKENDQYDTLD 910

  Fly   906 VGRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQ 970
            ||.|||||||:||.:|||:|..|.:||.:.||||::|.:||||:.|.|.:||.:||::.|.::||
Yeast   911 VGHYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLERSDLDLWNKVLNQENIHRRQ 975

  Fly   971 LIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIK 1035
            |||.|:...:.|..||:.:|:||:||||..|..|||||||||||:.|.|:::..||.||:|:|||
Yeast   976 LIDSVISVGIPELTDPEPVSLTVQAFMTNGLKLELIELLEKIILEPSPFNENVALQGLLLLSAIK 1040

  Fly  1036 ADRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFA 1100
            .:.|:|..||.:|:||||.:||.:.|.:.|.||||.|:.|.::...|::|||:.:.:|:||..:|
Yeast  1041 YEPTKVSSYIEKLDNYDADEIAPLCIEHDLKEEAFEIYDKHEMYGKALKVLIEDIMSLDRAASYA 1105

  Fly  1101 ERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKA 1165
            ::.|.|.:|||:..|||....:.:||:|||||:|||.|.:|:|:|.:...:::|:.:|.||||..
Yeast  1106 DKINTPELWSQIGTAQLDGLRIPDAIESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTL 1170

  Fly  1166 RESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAI 1230
            :|..|:..||.|||...::.::|..::|.|.|::..:|::.|.:..|.||:|.|:.|||:::||.
Yeast  1171 KEPKIDGALILAYAELNKIHEIENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLAS 1235

  Fly  1231 TLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRG 1295
            |||||.::|.|||:||||::.:.||.|..||::.:||:|||:|||:::|||:||::|:..|::.|
Yeast  1236 TLVYLGDYQAAVDTARKASNIKVWKLVNDACIEKKEFKLAQICGLNLIVHAEELDELVERYESNG 1300

  Fly  1296 YFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWS 1360
            ||:|||:|.|:.||||||||||||||||||||::|.|..|||:|||||:|||||:||.|.|||||
Yeast  1301 YFEELISLFEAGLGLERAHMGMFTELAILYSKYEPDKTFEHLKLFWSRINIPKVIRAVEQAHLWS 1365

  Fly  1361 ELVFLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLL 1425
            ||||||..|:|:|||.|.::...|:.....:||:::.||:|:|:|||||.||:.|.|.||.|:|.
Yeast  1366 ELVFLYAHYDEWDNAALTLIEKSTKDLDHAYFKEVVVKVSNLEIYYKAINFYVKFHPSLLVDLLT 1430

  Fly  1426 VLAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDN 1490
            .|.||:|..|.|..|||:..|||:||:|.:|...||..:|:|.:.|:|:||||:.|::::|.:|.
Yeast  1431 SLTPRLDIPRTVKIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEEDYKALQDAVDSYDK 1495

  Fly  1491 FDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELL 1555
            ||.:.||.:||.|:|..|::|.|.||:.|.:|.:|:.:.|::||:|||:|.||.|....:.|.||
Yeast  1496 FDQLGLASRLESHKLIFFKKIGALLYRRNKKWAKSLSILKEEKLWKDAIETAAISQDPKVVEALL 1560

  Fly  1556 GWFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQ 1620
            .:|:|....:.|.|.||..|:|:|.:.:||::|.:.:.|:..|:.|.:.:|....:.|  :.|..
Yeast  1561 TYFVETGNREGFVALLYAAYNLVRIEFVLEISWMNSLEDYIKPFEISIKKEQNDSIKK--ITEEL 1623

  Fly  1621 REKEDDSTEHKNIIQMEPQLMITAGPAMGIPP 1652
            .:|...:.|||     :.|.::....||.:.|
Yeast  1624 AKKSGSNEEHK-----DGQPLMLMNSAMNVQP 1650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_477042.1	Clathrin_propel	19..56	CDD:460192	15/36 (42%)
		Clathrin_propel	148..187	CDD:460192	17/38 (45%)
		Clathrin_propel	198..234	CDD:460192	13/38 (34%)
		Clathrin_propel	256..288	CDD:460192	22/31 (71%)
		Clathrin_propel	296..330	CDD:460192	16/33 (48%)
		Clathrin-link	331..354	CDD:462732	11/22 (50%)
		Clathrin_H_link	356..422	CDD:463995	28/65 (43%)
		CLH	542..672	CDD:128594	79/131 (60%)
		CLH	687..825	CDD:128594	76/137 (55%)
		CLH	834..969	CDD:128594	75/134 (56%)
		CLH	980..1118	CDD:128594	66/137 (48%)
		Clathrin	1129..1268	CDD:459884	59/138 (43%)
		CLH	1275..1417	CDD:128594	86/141 (61%)
		Clathrin	1429..1562	CDD:459884	59/132 (45%)
CHC1	NP_011309.1	Clathrin_propel	262..294	CDD:460192	22/31 (71%)
		Clathrin-link	338..360	CDD:462732	11/21 (52%)
		Clathrin_H_link	362..425	CDD:463995	28/65 (43%)
		CLH	544..680	CDD:128594	79/135 (59%)
		CLH	692..830	CDD:128594	76/137 (55%)
		CLH	839..974	CDD:128594	75/134 (56%)
		CLH	985..1126	CDD:128594	67/140 (48%)
		Clathrin	1134..1273	CDD:459884	59/138 (43%)
		CLH	1280..1422	CDD:128594	86/141 (61%)
		Clathrin	1429..1570	CDD:459884	61/140 (44%)