DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and CHC1

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_011309.1	Gene:	CHC1 / 852666	SGDID:	S000003174	Length:	1653	Species:	Saccharomyces cerevisiae

Alignment Length:	1657	Identity:	808/1657 - (48%)
Similarity:	1158/1657 - (69%)	Gaps:	19/1657 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRPISAD 69
            |||.|.|.:.|.::||:.....|.:.|.|||.|:.|||..:.|..|.|:|:......||:.:..|
Yeast     4 LPIEFTELVDLMSLGISPQFLDFRSTTFESDHFVTVRETKDGTNSVAIVDLAKGNEVTRKNMGGD 68

  Fly    70 SAIMNPASKVIALKAQKTL-QIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFHWSM- 132
            ||||:|:..||:::|..|: ||||:|.|||:|:.|::|.|:||:|:|..||..||..|:...::
Yeast    69 SAIMHPSQMVISVRANGTIVQIFNLETKSKLKSFTLDEPVIFWRWLSETTLGFVTARSILTSNVF 133

  Fly   133 EG--DSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAIE 195
            :|  ::.||.:..||::||..||||:..|.:..|..:|||.....|:||.:||:|.:|.:||||:
Yeast   134 DGNVNAKPQLLTLRHANLNNTQIINFVANKNLDWFAVVGILQENGRIAGRIQLFSKQRNISQAID 198

  Fly   196 GHAASFATFKIDAN-KEPTTLFCFAVRTAT--GGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQ 257
            ||.|.|....::.| ..|..:|....|.||  .|:|.|||:....:....:.|:..|:||||:|.
Yeast   199 GHVAIFTNILLEGNGSTPVQVFVTGNRNATTGAGELRIIEIDHDASLPSQYQKETTDIFFPPDAT 263

  Fly   258 NDFPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKG 322
            ||||:|:|||.||..|||:||||:||||::||.|.:::|||:|:::|..||:....||..:|:||
Yeast   264 NDFPIAVQVSEKYGIIYLLTKYGFIHLYELETGTNLFVNRITAESVFTAAPYNHENGIACINKKG 328

  Fly   323 QVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALA 387
            |||:|.:...||:|||...|.|..|||.:|.|..|.||:|||.::|..|.....|..||||||.:
Yeast   329 QVLAVEISTSQIVPYILNKLSNVALALIVATRGGLPGADDLFQKQFESLLLQNDYQNAAKVAASS 393

  Fly   388 PKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKW 452
            ..  ||...||.|.:.:|.|.|:.:|.|| ||..|||:|||||.|::||.||||.|.:|||.|||
Yeast   394 TS--LRNQNTINRLKNIQAPPGAISPILL-YFSTLLDKGKLNKEETIELARPVLQQDRKQLFEKW 455

  Fly   453 LKEEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVF 517
            |||:||||||||||:||..|.||||:.||||....|||.|.||..||:||:.|.:||.|.|:::.
Yeast   456 LKEDKLECSEELGDIVKPFDTTLALACYLRAGAHAKVISCLAELQQFEKIIPYCQKVGYQPNFLV 520

  Fly   518 LLRSVMRSNPEQGAGFASMLVAEEEPLA--DINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGA 580
            |:.|::||:|::.:.||..|:...|..:  ||.:|.|:|...:.:||.|:.||||||.:.|.:|.
Yeast   521 LISSLIRSSPDRASEFAVSLLQNPETASQIDIEKIADLFFSQNHIQQGTSLLLDALKGDTPDQGH 585

  Fly   581 LQTRLLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTH 645
            ||||:||:||:.|||||||||||.:|:|||:..||.|.|||||.|||||:|||:.||||.||||:
Yeast   586 LQTRVLEVNLLHAPQVADAILGNNIFSHYDKPTIASLSEKAGLYQRALENYTDIKDIKRCVVHTN 650

  Fly   646 MLNAEWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYD 710
            .|..:|||.:||.|:||.||.||||::..|::.|:|..||:|||:.:.:....||.|||.:.:.:
Yeast   651 ALPIDWLVGYFGKLNVEQSLACLKALMDNNIQANIQTVVQVATKFSDLIGPSTLIKLFEDYNATE 715

  Fly   711 GLFYFLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPL 775
            ||:|:|:|:||.::|.:|.:|||:||.|..|.:|:|||.:::|.|:|||||||||:|.|.|||||
Yeast   716 GLYYYLASLVNLTEDKDVVYKYIEAAAKMKQYREIERIVKDNNVYDPERVKNFLKDANLEDQLPL 780

  Fly   776 IIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQ 840
            :||||||||||:::||||::...|:||.|||:||||:...|||.|||:||.|..|::|:..|.||
Yeast   781 VIVCDRFDFVHEMILYLYKSQNLKFIETYVQQVNPSKTAQVVGALLDMDCDEAFIQSLLQSVLGQ 845

  Fly   841 FSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRV 905
            ...:||..|||||||||:|||:||..:.:|..:.|.:||||||||||||:||::||||..||:..
Yeast   846 VPINELTTEVEKRNRLKILLPFLEQSLSQGIQDQAVYNALAKIYIDSNNSPEKFLKENDQYDTLD 910

  Fly   906 VGRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQ 970
            ||.|||||||:||.:|||:|..|.:||.:.||||::|.:||||:.|.|.:||.:||::.|.::||
Yeast   911 VGHYCEKRDPYLAYIAYEKGQNDDDLIRITNENSMYKYQARYLLERSDLDLWNKVLNQENIHRRQ 975

  Fly   971 LIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIK 1035
            |||.|:...:.|..||:.:|:||:||||..|..|||||||||||:.|.|:::..||.||:|:|||
Yeast   976 LIDSVISVGIPELTDPEPVSLTVQAFMTNGLKLELIELLEKIILEPSPFNENVALQGLLLLSAIK 1040

  Fly  1036 ADRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFA 1100
            .:.|:|..||.:|:||||.:||.:.|.:.|.||||.|:.|.::...|::|||:.:.:|:||..:|
Yeast  1041 YEPTKVSSYIEKLDNYDADEIAPLCIEHDLKEEAFEIYDKHEMYGKALKVLIEDIMSLDRAASYA 1105

  Fly  1101 ERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKA 1165
            ::.|.|.:|||:..|||....:.:||:|||||:|||.|.:|:|:|.:...:::|:.:|.||||..
Yeast  1106 DKINTPELWSQIGTAQLDGLRIPDAIESYIKAEDPSNYENVIDIAEQAGKYEELIPFLLMARKTL 1170

  Fly  1166 RESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAI 1230
            :|..|:..||.|||...::.::|..::|.|.|::..:|::.|.:..|.||:|.|:.|||:::||.
Yeast  1171 KEPKIDGALILAYAELNKIHEIENLLAGSNVANLDHVGDKLFENKEYKAARLCYSAVSNYSKLAS 1235

  Fly  1231 TLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRG 1295
            |||||.::|.|||:||||::.:.||.|..||::.:||:|||:|||:::|||:||::|:..|::.|
Yeast  1236 TLVYLGDYQAAVDTARKASNIKVWKLVNDACIEKKEFKLAQICGLNLIVHAEELDELVERYESNG 1300

  Fly  1296 YFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWS 1360
            ||:|||:|.|:.||||||||||||||||||||::|.|..|||:|||||:|||||:||.|.|||||
Yeast  1301 YFEELISLFEAGLGLERAHMGMFTELAILYSKYEPDKTFEHLKLFWSRINIPKVIRAVEQAHLWS 1365

  Fly  1361 ELVFLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLL 1425
            ||||||..|:|:|||.|.::...|:.....:||:::.||:|:|:|||||.||:.|.|.||.|:|.
Yeast  1366 ELVFLYAHYDEWDNAALTLIEKSTKDLDHAYFKEVVVKVSNLEIYYKAINFYVKFHPSLLVDLLT 1430

  Fly  1426 VLAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDN 1490
            .|.||:|..|.|..|||:..|||:||:|.:|...||..:|:|.:.|:|:||||:.|::::|.:|.
Yeast  1431 SLTPRLDIPRTVKIFSKSDNLPLIKPFLINVLPKNNSVVNQAYHDLMIEEEDYKALQDAVDSYDK 1495

  Fly  1491 FDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELL 1555
            ||.:.||.:||.|:|..|::|.|.||:.|.:|.:|:.:.|::||:|||:|.||.|....:.|.||
Yeast  1496 FDQLGLASRLESHKLIFFKKIGALLYRRNKKWAKSLSILKEEKLWKDAIETAAISQDPKVVEALL 1560

  Fly  1556 GWFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQ 1620
            .:|:|....:.|.|.||..|:|:|.:.:||::|.:.:.|:..|:.|.:.:|....:.|  :.|..
Yeast  1561 TYFVETGNREGFVALLYAAYNLVRIEFVLEISWMNSLEDYIKPFEISIKKEQNDSIKK--ITEEL 1623

  Fly  1621 REKEDDSTEHKNIIQMEPQLMITAGPAMGIPP 1652
            .:|...:.|||     :.|.::....||.:.|
Yeast  1624 AKKSGSNEEHK-----DGQPLMLMNSAMNVQP 1650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	15/36 (42%)
		Clathrin_propel	148..187	CDD:279702	17/38 (45%)
		Clathrin_propel	198..234	CDD:279702	13/38 (34%)
		Clathrin_propel	256..288	CDD:279702	22/31 (71%)
		Clathrin_propel	296..330	CDD:279702	16/33 (48%)
		Clathrin-link	331..353	CDD:286367	10/21 (48%)
		Clathrin_H_link	364..422	CDD:290550	23/57 (40%)
		CLH	542..672	CDD:128594	79/131 (60%)
		Clathrin	546..679	CDD:279031	79/132 (60%)
		CLH	687..825	CDD:128594	76/137 (55%)
		Clathrin	697..827	CDD:279031	75/129 (58%)
		CLH	834..969	CDD:128594	75/134 (56%)
		Clathrin	844..971	CDD:279031	73/126 (58%)
		CLH	980..1118	CDD:128594	66/137 (48%)
		Clathrin	984..1120	CDD:279031	66/135 (49%)
		CLH	1129..1266	CDD:128594	58/136 (43%)
		Clathrin	1134..1268	CDD:279031	55/133 (41%)
		CLH	1275..1417	CDD:128594	86/141 (61%)
		Clathrin	1279..1417	CDD:279031	85/137 (62%)
		CLH	1428..1579	CDD:128594	65/150 (43%)
		Clathrin	1429..1562	CDD:279031	59/132 (45%)
CHC1	NP_011309.1	Clathrin_propel	262..294	CDD:396117	22/31 (71%)
		Clathrin-link	338..360	CDD:401271	11/21 (52%)
		Clathrin_H_link	362..425	CDD:404683	28/65 (43%)
		CLH	544..680	CDD:128594	79/135 (59%)
		CLH	692..830	CDD:128594	76/137 (55%)
		CLH	839..974	CDD:128594	75/134 (56%)
		Clathrin	985..1123	CDD:395512	66/137 (48%)
		Clathrin	1134..1270	CDD:395512	58/135 (43%)
		CLH	1280..1422	CDD:128594	86/141 (61%)
		Clathrin	1429..1567	CDD:395512	61/137 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346458
Domainoid	1	1.000	195	1.000	Domainoid score	I606
eggNOG	1	0.900	-	-		E1_KOG0985
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	1503	1.000	Inparanoid score	I9
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53703
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		oto99118
orthoMCL	1	0.900	-	-		OOG6_101144
Panther	1	1.100	-	-	LDO	PTHR10292
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R209
SonicParanoid	1	1.000	-	-		X1532
TreeFam	1	0.960	-	-
	15	14.790