DRSC/TRiP Functional Genomics Resources

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Protein Alignment Chc and CLTCL1

DIOPT Version :9

Sequence 1:NP_001096993.1 Gene:Chc / 32537 FlyBaseID:FBgn0000319 Length:1678 Species:Drosophila melanogaster
Sequence 2:NP_009029.3 Gene:CLTCL1 / 8218 HGNCID:2093 Length:1640 Species:Homo sapiens


Alignment Length:1629 Identity:1260/1629 - (77%)
Similarity:1452/1629 - (89%) Gaps:1/1629 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MTQPLPIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRP 65
            |.|.||:|||||.||.|:|||..:..|||||||||||||:||||.:.|||.||||:|...|.|||
Human     1 MAQILPVRFQEHFQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVTIIDMSDPMAPIRRP 65

  Fly    66 ISADSAIMNPASKVIALKAQKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFHW 130
            |||:|||||||||||||||.|||||||||||||||||||.|:|:||||:|:||:||||||:|:||
Human    66 ISAESAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMAEEVIFWKWVSVNTVALVTETAVYHW 130

  Fly   131 SMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGISALPSRVAGAMQLYSVERKVSQAIE 195
            ||||||.|.||||||:||.|||:|:||.:..|:|||||||||..:||.||||||||:|||||.||
Human   131 SMEGDSQPMKMFDRHTSLVGCQVIHYRTDEYQKWLLLVGISAQQNRVVGAMQLYSVDRKVSQPIE 195

  Fly   196 GHAASFATFKIDANKEPTTLFCFAVRTATGGKLHIIEVGAPPNGNQPFAKKAVDVFFPPEAQNDF 260
            ||||:||.||::.|.:|.||||||||..|||||||||||.|..|||||.||||||||||||||||
Human   196 GHAAAFAEFKMEGNAKPATLFCFAVRNPTGGKLHIIEVGQPAAGNQPFVKKAVDVFFPPEAQNDF 260

  Fly   261 PVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGIIGVNRKGQVL 325
            |||||:.||:..|||||||||:||||:|:..||.|||||||||||||||:.:.||||||:|||||
Human   261 PVAMQIGAKHGVIYLITKYGYLHLYDLESGVCICMNRISADTIFVTAPHKPTSGIIGVNKKGQVL 325

  Fly   326 SVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAAKVAALAPKA 390
            ||.|:|:.|:.|...|||||||.||:|||:||||||.|||||||.||..|.|||||||||.|||.
Human   326 SVCVEEDNIVNYATNVLQNPDLGLRLAVRSNLAGAEKLFVRKFNTLFAQGSYAEAAKVAASAPKG 390

  Fly   391 ILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKKQLCEKWLKE 455
            ||||.:|:|:||.:...:|..: |||||||||||||:|||.||||||..||.||:|||.||||||
Human   391 ILRTRETVQKFQSIPAQSGQAS-PLLQYFGILLDQGQLNKLESLELCHLVLQQGRKQLLEKWLKE 454

  Fly   456 EKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNYTPDYVFLLR 520
            :|||||||||||||.:|..||||:|||||||:||||||||||||||||||||||.||||::||||
Human   455 DKLECSEELGDLVKTTDPMLALSVYLRANVPSKVIQCFAETGQFQKIVLYAKKVGYTPDWIFLLR 519

  Fly   521 SVMRSNPEQGAGFASMLVAEEEPLADINQIVDIFMEHSMVQQCTAFLLDALKHNRPAEGALQTRL 585
            .||:.:||||..|:.|||.:|||||:|:||||||||:|::||||:|||||||:||||||.|||.|
Human   520 GVMKISPEQGLQFSRMLVQDEEPLANISQIVDIFMENSLIQQCTSFLLDALKNNRPAEGLLQTWL 584

  Fly   586 LEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKRAVVHTHMLNAE 650
            |||||:.|||||||||||.|||||||||||||||||||||:|||||||||||||||||||:||.|
Human   585 LEMNLVHAPQVADAILGNKMFTHYDRAHIAQLCEKAGLLQQALEHYTDLYDIKRAVVHTHLLNPE 649

  Fly   651 WLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFEGFKSYDGLFYF 715
            |||:|||:||||||:|||.|||:||:|||||:|||:|:||||||..:||::|||.||||.|||||
Human   650 WLVNFFGSLSVEDSVECLHAMLSANIRQNLQLCVQVASKYHEQLGTQALVELFESFKSYKGLFYF 714

  Fly   716 LSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKLTDQLPLIIVCD 780
            |.|||||||||:||.|||||||||.||||||||||||:|||||||||||||||||||||||||||
Human   715 LGSIVNFSQDPDVHLKYIQAACKTGQIKEVERICRESSCYNPERVKNFLKEAKLTDQLPLIIVCD 779

  Fly   781 RFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLILVVKGQFSTDE 845
            ||.|||||||||||||||:|||||||||||||.|.|:||||||||||::||:||:.|:|||||||
Human   780 RFGFVHDLVLYLYRNNLQRYIEIYVQKVNPSRTPAVIGGLLDVDCSEEVIKHLIMAVRGQFSTDE 844

  Fly   846 LVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQYYDSRVVGRYC 910
            ||.|||||||||||||||||::.|||.|||||||||||||||||:||.:|:||.||||.||||||
Human   845 LVAEVEKRNRLKLLLPWLESQIQEGCEEPATHNALAKIYIDSNNSPECFLRENAYYDSSVVGRYC 909

  Fly   911 EKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSESNPYKRQLIDQV 975
            |||||||||||||||.||.|||.||||||||||||||||.|:|.||||.||.|:||.:|||||||
Human   910 EKRDPHLACVAYERGQCDLELIKVCNENSLFKSEARYLVCRKDPELWAHVLEETNPSRRQLIDQV 974

  Fly   976 VQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLLILTAIKADRTR 1040
            ||||||||:||::||||||||||||||||||||||||:||:||||:|||||||||||||||||||
Human   975 VQTALSETRDPEEISVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTR 1039

  Fly  1041 VMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLERANEFAERCNE 1105
            ||:||:||:||||.|||:||:|:.||||||.:|.|||:|.|||||||:.:.||:||.||||||||
Human  1040 VMEYISRLDNYDALDIASIAVSSALYEEAFTVFHKFDMNASAIQVLIEHIGNLDRAYEFAERCNE 1104

  Fly  1106 PAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQMARKKARESYI 1170
            ||||||||:||||:.||||||:|||:.||||:|::||..||:..:|:|||::|||||||.|||||
Human  1105 PAVWSQLAQAQLQKDLVKEAINSYIRGDDPSSYLEVVQSASRSNNWEDLVKFLQMARKKGRESYI 1169

  Fly  1171 ESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSNFARLAITLVYL 1235
            |:|||:|.|:|.|:::||:||:|||:|.||::|:||:.:|||:||||||:|||||||||.|||:|
Human  1170 ETELIFALAKTSRVSELEDFINGPNNAHIQQVGDRCYEEGMYEAAKLLYSNVSNFARLASTLVHL 1234

  Fly  1236 KEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLINYYQNRGYFDEL 1300
            .|:|.|||::|||:||||||||||||:|.:|||.||:||||||:||||||:|:.|||:||||:||
Human  1235 GEYQAAVDNSRKASSTRTWKEVCFACMDGQEFRFAQLCGLHIVIHADELEELMCYYQDRGYFEEL 1299

  Fly  1301 IALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAESAHLWSELVFL 1365
            |.|||:||||||||||||||||||||||||.||.||||||||||||||||||||.||||:|||||
Human  1300 ILLLEAALGLERAHMGMFTELAILYSKFKPQKMLEHLELFWSRVNIPKVLRAAEQAHLWAELVFL 1364

  Fly  1366 YDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLLLNDMLLVLAPR 1430
            ||||||||||||.||:||||||:||.||||||||||:||.|:|::||||:||||:||:||||:||
Human  1365 YDKYEEYDNAVLTMMSHPTEAWKEGQFKDIITKVANVELCYRALQFYLDYKPLLINDLLLVLSPR 1429

  Fly  1431 MDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNSIDGFDNFDNIA 1495
            :|||..||:|||.|.|||||||||||||.|||::|||||.||.:||||||||.|||.:||||||:
Human  1430 LDHTWTVSFFSKAGQLPLVKPYLRSVQSHNNKSVNEALNHLLTEEEDYQGLRASIDAYDNFDNIS 1494

  Fly  1496 LAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQDIAEELLGWFLE 1560
            |||:||||:|.|||.||||||||||.|.|||||||||.||||||::||||...::|::||.||||
Human  1495 LAQQLEKHQLMEFRCIAAYLYKGNNWWAQSVELCKKDHLYKDAMQHAAESRDAELAQKLLQWFLE 1559

  Fly  1561 RDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKLELNEAQREKED 1625
            ....:||||||:.||||||||::|||||:|.:||.||||.|||:|||.:|||||:..|:.|::|:
Human  1560 EGKRECFAACLFTCYDLLRPDMVLELAWRHNLVDLAMPYFIQVMREYLSKVDKLDALESLRKQEE 1624

  Fly  1626 DSTE 1629
            ..||
Human  1625 HVTE 1628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ChcNP_001096993.1 Clathrin_propel 19..56 CDD:279702 26/36 (72%)
Clathrin_propel 148..187 CDD:279702 26/38 (68%)
Clathrin_propel 198..234 CDD:279702 25/35 (71%)
Clathrin_propel 256..288 CDD:279702 25/31 (81%)
Clathrin_propel 296..330 CDD:279702 27/33 (82%)
Clathrin-link 331..353 CDD:286367 12/21 (57%)
Clathrin_H_link 364..422 CDD:290550 37/57 (65%)
CLH 542..672 CDD:128594 110/129 (85%)
Clathrin 546..679 CDD:279031 111/132 (84%)
CLH 687..825 CDD:128594 119/137 (87%)
Clathrin 697..827 CDD:279031 114/129 (88%)
CLH 834..969 CDD:128594 110/134 (82%)
Clathrin 844..971 CDD:279031 104/126 (83%)
CLH 980..1118 CDD:128594 111/137 (81%)
Clathrin 984..1120 CDD:279031 109/135 (81%)
CLH 1129..1266 CDD:128594 91/136 (67%)
Clathrin 1134..1268 CDD:279031 89/133 (67%)
CLH 1275..1417 CDD:128594 119/141 (84%)
Clathrin 1279..1417 CDD:279031 115/137 (84%)
CLH 1428..1579 CDD:128594 109/150 (73%)
Clathrin 1429..1562 CDD:279031 99/132 (75%)
CLTCL1NP_009029.3 Globular terminal domain 2..479 354/477 (74%)
Clathrin_propel 19..55 CDD:279702 25/35 (71%)
WD40-like repeat 1 24..67 29/42 (69%)
WD40-like repeat 2 68..107 35/38 (92%)
WD40-like repeat 3 108..149 31/40 (78%)
WD40-like repeat 4 150..195 31/44 (70%)
WD40-like repeat 5 196..257 46/60 (77%)
Clathrin_propel 198..234 CDD:279702 25/35 (71%)
Clathrin_propel 256..288 CDD:279702 25/31 (81%)
WD40-like repeat 6 258..301 31/42 (74%)
Clathrin_propel 296..330 CDD:279702 27/33 (82%)
WD40-like repeat 7 302..330 21/27 (78%)
Clathrin-link 331..353 CDD:286367 12/21 (57%)
Clathrin_H_link 364..421 CDD:290550 37/57 (65%)
Binding site for the uncoating ATPase, involved in lattice disassembly. /evidence=ECO:0000255 449..465 14/15 (93%)
Flexible linker 480..523 37/42 (88%)
Heavy chain arm 524..1640 866/1105 (78%)
Distal segment 524..634 88/109 (81%)
CLH 541..674 CDD:128594 112/132 (85%)
Clathrin 545..678 CDD:279031 111/132 (84%)
Proximal segment 639..1640 772/990 (78%)
CLH 686..824 CDD:128594 119/137 (87%)
Clathrin 696..826 CDD:279031 114/129 (88%)
CLH 833..960 CDD:128594 105/126 (83%)
Clathrin 843..970 CDD:279031 104/126 (83%)
CLH 979..1119 CDD:128594 113/139 (81%)
Clathrin 983..1119 CDD:279031 109/135 (81%)
CLH 1128..1265 CDD:128594 91/136 (67%)
Clathrin 1133..1267 CDD:279031 89/133 (67%)
Involved in binding clathrin light chain. /evidence=ECO:0000250 1213..1522 248/308 (81%)
CLH 1274..1416 CDD:128594 119/141 (84%)
Clathrin 1279..1416 CDD:279031 115/136 (85%)
CLH 1427..1578 CDD:128594 109/150 (73%)
Clathrin 1427..1564 CDD:279031 99/136 (73%)
Trimerization. /evidence=ECO:0000250 1551..1640 48/78 (62%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159604
Domainoid 1 1.000 264 1.000 Domainoid score I1925
eggNOG 1 0.900 - - E1_KOG0985
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 2706 1.000 Inparanoid score I26
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53703
OrthoDB 1 1.010 - - D17940at2759
OrthoFinder 1 1.000 - - FOG0002324
OrthoInspector 1 1.000 - - otm40522
orthoMCL 1 0.900 - - OOG6_101144
Panther 1 1.100 - - O PTHR10292
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R209
SonicParanoid 1 1.000 - - X1532
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1413.840

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