DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and AT3G11130

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_187724.2	Gene:	AT3G11130 / 820284	AraportID:	AT3G11130	Length:	1705	Species:	Arabidopsis thaliana

Alignment Length:	1695	Identity:	948/1695 - (55%)
Similarity:	1236/1695 - (72%)	Gaps:	27/1695 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRPISADS 70
            ||..:|.|.|.:|||.....:|:.:||||||:|||||.....: |||||||....|.||||:|||
plant     7 PIIMKEVLTLPSVGIGQQFITFTNVTMESDKYICVRETAPQNS-VVIIDMNMPMQPLRRPITADS 70

  Fly    71 AIMNPASKVIALKA------QKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |:|||.|:::||||      |..|||||||.|:|:|:|.|.|.|.|||||:...|.|||:|||:|
plant    71 ALMNPNSRILALKAQVPGTTQDHLQIFNIEAKAKLKSHQMPEQVAFWKWITPKMLGLVTQTSVYH 135

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGIS----ALPSRVAGAMQLYSVERKV 190
            ||:||||.|.|||||.::|...|||||:|:.:::||:|:||:    ..|..|.|.|||:||:::.
plant   136 WSIEGDSEPVKMFDRTANLANNQIINYKCSPNEKWLVLIGIAPGSPERPQLVKGNMQLFSVDQQR 200

  Fly   191 SQAIEGHAASFATFKIDANKEPTTLFCFAVRTATGG----KLHIIEVGAPPNGNQPFAKKAVDVF 251
            |||:|.||||||.||:..|:.|:.|..||.::...|    |||:||:||.| |...|.||..|:|
plant   201 SQALEAHAASFAQFKVPGNENPSILISFASKSFNAGQITSKLHVIELGAQP-GKPSFTKKQADLF 264

  Fly   252 FPPEAQNDFPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGII 316
            |||:..:|||||||||.|::.||:|||.|.:.:||:|||:.||.||||.|.||:|:...:.||..
plant   265 FPPDFADDFPVAMQVSHKFNLIYVITKLGLLFVYDLETASAIYRNRISPDPIFLTSEASSVGGFY 329

  Fly   317 GVNRKGQVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAA 381
            .:||:||||..||:|..|||:|:..|.|.:||:.:|.|.||.|||:|.|::|.:||...:|.|||
plant   330 AINRRGQVLLATVNEATIIPFISGQLNNLELAVNLAKRGNLPGAENLVVQRFQELFAQTKYKEAA 394

  Fly   382 KVAALAPKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKK 446
            ::||.:|:.|||||.|:.:||.|...||. |||||||||.||.:||||.:|||||.|.|:.|.||
plant   395 ELAAESPQGILRTPDTVAKFQSVPVQAGQ-TPPLLQYFGTLLTRGKLNSYESLELSRLVVNQNKK 458

  Fly   447 QLCEKWLKEEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNY 511
            .|.|.||.|:|||||||||||||..|..|||.||::|....||:..|||..:|.||::|:|:|.|
plant   459 NLLENWLAEDKLECSEELGDLVKTVDNDLALKIYIKARATPKVVAAFAERREFDKILIYSKQVGY 523

  Fly   512 TPDYVFLLRSVMRSNPEQGAGFASMLVAEEE--PLADINQIVDIFMEHSMVQQCTAFLLDALKHN 574
            ||||:|||::::|::|:....||.|:...|.  |: |.|.|.|:|::.:::::.||||||.||.|
plant   524 TPDYMFLLQTILRTDPQGAVNFALMMSQMEGGCPV-DYNTITDLFLQRNLIREATAFLLDVLKPN 587

  Fly   575 RPAEGALQTRLLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKR 639
            .|....|||::||:||::.|.||||||.|.||:||||..:|||||||||..::|:||::|.||||
plant   588 LPEHAFLQTKVLEINLVTFPNVADAILANGMFSHYDRPRVAQLCEKAGLYIQSLKHYSELPDIKR 652

  Fly   640 AVVHTHMLNAEWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFE 704
            .:|:||.:..:.||.||||||.|.::||:|.:|..|||.||||.||...:|.|||...|.|.|||
plant   653 VIVNTHAIEPQALVEFFGTLSSEWAMECMKDLLLVNLRGNLQIIVQACKEYCEQLGVDACIKLFE 717

  Fly   705 GFKSYDGLFYFLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKL 769
            .||||:||::||.|.::.|:|||:|||||:||.||.|||||||:.||||.|:.|:.||||.||||
plant   718 QFKSYEGLYFFLGSYLSMSEDPEIHFKYIEAAAKTGQIKEVERVTRESNFYDAEKTKNFLMEAKL 782

  Fly   770 TDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLI 834
            .|..|||.|||||.||.||..|||.||:.:|||.|||||||...|:|||.|||.:|.||.||.||
plant   783 PDARPLINVCDRFGFVPDLTHYLYTNNMLRYIEGYVQKVNPGNAPLVVGQLLDDECPEDFIKGLI 847

  Fly   835 LVVKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQ 899
            |.|:.....:.||.|.||||||:||..:||..|.||..:...||||.||.||||||||.:|..|.
plant   848 LSVRSLLPVEPLVAECEKRNRLRLLTQFLEHLVSEGSQDVHVHNALGKIIIDSNNNPEHFLTTNP 912

  Fly   900 YYDSRVVGRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSES 964
            ||||:|||:|||||||.||.|||.||.||.|||.|.|:|||||.:|||:|.|.|.:||.:||:|.
plant   913 YYDSKVVGKYCEKRDPTLAVVAYRRGQCDEELINVTNKNSLFKLQARYVVERMDGDLWEKVLTEE 977

  Fly   965 NPYKRQLIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLL 1029
            |.|:||||||||.|||.|::.|:.:|..||||||||||:|||||||||:|.:|.||.:.||||||
plant   978 NEYRRQLIDQVVSTALPESKSPEQVSAAVKAFMTADLPHELIELLEKIVLQNSAFSGNFNLQNLL 1042

  Fly  1030 ILTAIKADRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLE 1094
            ||||||||.:|||||||||:|:|.|.:..:|:..|||||||||||||::|..|:.||:|.|.::|
plant  1043 ILTAIKADPSRVMDYINRLDNFDGPAVGEVAVDAQLYEEAFAIFKKFNLNVQAVNVLLDNVRSIE 1107

  Fly  1095 RANEFAERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQ 1159
            ||.|||.|..|.|||||:|||||::|||.:||:|:|:|||.:.:::|:..:.....:|||||||.
plant  1108 RAVEFAFRVEEDAVWSQVAKAQLREGLVSDAIESFIRADDTTQFLEVIRASEDTNVYDDLVRYLL 1172

  Fly  1160 MARKKARESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSN 1224
            |.|:|.:|..::||||||||:..||.::||||..||.|::|.:|:|.:.:.:|:|||::|..:||
plant  1173 MVRQKVKEPKVDSELIYAYAKIERLGEIEEFILMPNVANLQHVGDRLYDEALYEAAKIIYAFISN 1237

  Fly  1225 FARLAITLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLIN 1289
            :|:||:|||.|::||||||:||||||.:|||||||||||||||||||:|||:|::..|:||::..
plant  1238 WAKLAVTLVKLQQFQGAVDAARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSE 1302

  Fly  1290 YYQNRGYFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAE 1354
            ||||||.|:|||:|:||.|||||||||:||||.:||::::..|:.||::||.:|:||||::||.:
plant  1303 YYQNRGCFNELISLMESGLGLERAHMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACD 1367

  Fly  1355 SAHLWSELVFLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLL 1419
            ....|.||.:||.:|:|:|||...:|.|..|||....||||:.||||:||||||:.|||...|.:
plant  1368 EQQHWQELTYLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDI 1432

  Fly  1420 LNDMLLVLAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNS 1484
            :||:|.|||.|:||||.|....|.|:|.|:|||:.:|||.|..|:|||||.:..:||||..||.|
plant  1433 INDLLNVLALRLDHTRVVDIMRKAGHLRLIKPYMVAVQSNNVSAVNEALNEIYAEEEDYDRLRES 1497

  Fly  1485 IDGFDNFDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQD 1549
            ||..|:||.|.||||:|||||.|.||:|||:||...|||||:.|.|||.:|||.||.|::|...|
plant  1498 IDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETASQSGDHD 1562

  Fly  1550 IAEELLGWFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKL 1614
            :||:||.:|:|:...:|||.||:.||||:||||.|||||.:.::|||.|||:|.:|||:.|||:|
plant  1563 LAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMIDFAFPYLLQFIREYSGKVDEL 1627

  Fly  1615 --ELNEAQREKEDDSTEHKNII---QMEPQLMITAGPAMGIPPQYAQNY--PPGAATVTAAGGRN 1672
              :..|||:|.:....|.|:::   .|..||:..|.||..:|......|  ||....:....|..
plant  1628 IKDKLEAQKEVKAKEQEEKDVMSQQNMYAQLLPLALPAPPMPGMGGGGYGPPPQMGGMPGMSGMP 1692

  Fly  1673 MGYPY 1677
            ...||
plant  1693 PMPPY 1697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	19/36 (53%)
		Clathrin_propel	148..187	CDD:279702	19/42 (45%)
		Clathrin_propel	198..234	CDD:279702	18/39 (46%)
		Clathrin_propel	256..288	CDD:279702	18/31 (58%)
		Clathrin_propel	296..330	CDD:279702	17/33 (52%)
		Clathrin-link	331..353	CDD:286367	9/21 (43%)
		Clathrin_H_link	364..422	CDD:290550	31/57 (54%)
		CLH	542..672	CDD:128594	69/131 (53%)
		Clathrin	546..679	CDD:279031	72/132 (55%)
		CLH	687..825	CDD:128594	87/137 (64%)
		Clathrin	697..827	CDD:279031	84/129 (65%)
		CLH	834..969	CDD:128594	81/134 (60%)
		Clathrin	844..971	CDD:279031	79/126 (63%)
		CLH	980..1118	CDD:128594	90/137 (66%)
		Clathrin	984..1120	CDD:279031	89/135 (66%)
		CLH	1129..1266	CDD:128594	74/136 (54%)
		Clathrin	1134..1268	CDD:279031	73/133 (55%)
		CLH	1275..1417	CDD:128594	77/141 (55%)
		Clathrin	1279..1417	CDD:279031	75/137 (55%)
		CLH	1428..1579	CDD:128594	86/150 (57%)
		Clathrin	1429..1562	CDD:279031	76/132 (58%)
AT3G11130	NP_187724.2	Clathrin_propel	20..56	CDD:396117	19/36 (53%)
		Clathrin_propel	154..197	CDD:396117	19/42 (45%)
		Clathrin_propel	266..301	CDD:396117	20/34 (59%)
		Clathrin-link	344..367	CDD:401271	10/22 (45%)
		Clathrin_H_link	369..434	CDD:404683	37/65 (57%)
		CLH	552..688	CDD:128594	71/136 (52%)
		CLH	701..838	CDD:128594	87/136 (64%)
		CLH	847..982	CDD:128594	81/134 (60%)
		CLH	993..1132	CDD:128594	91/138 (66%)
		Clathrin	1142..1278	CDD:395512	73/135 (54%)
		CLH	1288..1430	CDD:128594	77/141 (55%)
		Clathrin	1437..1575	CDD:395512	80/137 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I1000
eggNOG	1	0.900	-	-		E1_KOG0985
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	1765	1.000	Inparanoid score	I5
OMA	1	1.010	-	-		QHG53703
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm3142
orthoMCL	1	0.900	-	-		OOG6_101144
Panther	1	1.100	-	-	O	PTHR10292
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840