DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Chc and AT3G08530

DIOPT Version :9

Sequence 1:	NP_001096993.1	Gene:	Chc / 32537	FlyBaseID:	FBgn0000319	Length:	1678	Species:	Drosophila melanogaster
Sequence 2:	NP_187466.4	Gene:	AT3G08530 / 820001	AraportID:	AT3G08530	Length:	1703	Species:	Arabidopsis thaliana

Alignment Length:	1692	Identity:	949/1692 - (56%)
Similarity:	1241/1692 - (73%)	Gaps:	39/1692 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PIRFQEHLQLTNVGINANSFSFSTLTMESDKFICVREKVNDTAQVVIIDMNDATNPTRRPISADS 70
            ||..:|.|.|.::|||....:|:.:||||||:||||| .:....|||||||....|.||||:|||
plant     7 PITMKEVLTLPSIGINQQFITFTNVTMESDKYICVRE-TSPQNSVVIIDMNMPMQPLRRPITADS 70

  Fly    71 AIMNPASKVIALKA------QKTLQIFNIEMKSKMKAHTMNEDVVFWKWISLNTLALVTETSVFH 129
            |:|||.||::||||      |..|||||||.|:|:|:|.|.|.|||||||:...|.|||:.||:|
plant    71 ALMNPNSKILALKAQVPGTTQDHLQIFNIEAKAKLKSHQMPEQVVFWKWITPKMLGLVTQNSVYH 135

  Fly   130 WSMEGDSMPQKMFDRHSSLNGCQIINYRCNASQQWLLLVGIS-ALPSR---VAGAMQLYSVERKV 190
            ||:||||.|.|||||.::|...|||||:|:.:::||:|:||: ..|.|   |.|.|||:||:::.
plant   136 WSIEGDSEPVKMFDRTANLANNQIINYKCSPNEKWLVLIGIAPGSPERQQLVKGNMQLFSVDQQR 200

  Fly   191 SQAIEGHAASFATFKIDANKEPTTLFCFAVRTATGG----KLHIIEVGAPPNGNQPFAKKAVDVF 251
            |||:|.||||||.||:..|:.|:.|..||.::...|    |||:||:||.| |...|.||..|:|
plant   201 SQALEAHAASFAQFKVPGNENPSILISFASKSFNAGQITSKLHVIELGAQP-GKPSFTKKQADLF 264

  Fly   252 FPPEAQNDFPVAMQVSAKYDTIYLITKYGYIHLYDMETATCIYMNRISADTIFVTAPHEASGGII 316
            |||:..:|||||||||.|::.||:|||.|.:.:||:|||:.||.||||.|.||:|:...:.||..
plant   265 FPPDFADDFPVAMQVSHKFNLIYVITKLGLLFVYDLETASAIYRNRISPDPIFLTSEASSVGGFY 329

  Fly   317 GVNRKGQVLSVTVDEEQIIPYINTVLQNPDLALRMAVRNNLAGAEDLFVRKFNKLFTAGQYAEAA 381
            .:||:||||..||:|..|||:|:..|.|.:||:.:|.|.||.|||:|.|::|.:||...:|.|||
plant   330 AINRRGQVLLATVNEATIIPFISGQLNNLELAVNLAKRGNLPGAENLVVQRFQELFAQTKYKEAA 394

  Fly   382 KVAALAPKAILRTPQTIQRFQQVQTPAGSTTPPLLQYFGILLDQGKLNKFESLELCRPVLLQGKK 446
            ::||.:|:.|||||.|:.:||.|...||. |||||||||.||.:||||.:|||||.|.|:.|.||
plant   395 ELAAESPQGILRTPDTVAKFQSVPVQAGQ-TPPLLQYFGTLLTRGKLNSYESLELSRLVVNQNKK 458

  Fly   447 QLCEKWLKEEKLECSEELGDLVKASDLTLALSIYLRANVPNKVIQCFAETGQFQKIVLYAKKVNY 511
            .|.|.||.|:|||||||||||||..|..|||.||::|....||:..|||..:|.||::|:|:|.|
plant   459 NLLENWLAEDKLECSEELGDLVKTVDNDLALKIYIKARATPKVVAAFAERREFDKILIYSKQVGY 523

  Fly   512 TPDYVFLLRSVMRSNPEQGAGFASMLVAEE--EPLADINQIVDIFMEHSMVQQCTAFLLDALKHN 574
            ||||:|||::::|::|:....||.|:...|  .|: |.|.|.|:|::.:::::.|:||||.||.|
plant   524 TPDYLFLLQTILRTDPQGAVNFALMMSQMEGGSPV-DYNTITDLFLQRNLIREATSFLLDVLKPN 587

  Fly   575 RPAEGALQTRLLEMNLMSAPQVADAILGNAMFTHYDRAHIAQLCEKAGLLQRALEHYTDLYDIKR 639
            .|....|||::||:||::.|.||||:|.|.|||||||..||||||||||..::|:||::|.||||
plant   588 LPEHAFLQTKVLEINLVTFPNVADAVLANGMFTHYDRPRIAQLCEKAGLYIQSLKHYSELPDIKR 652

  Fly   640 AVVHTHMLNAEWLVSFFGTLSVEDSLECLKAMLTANLRQNLQICVQIATKYHEQLTNKALIDLFE 704
            .:|:||.:..:.||.||||||.|.::||:|.:|..|||.||||.||...:|.|||...|.|.|||
plant   653 VIVNTHAIEPQALVEFFGTLSSEWAMECMKDLLLVNLRGNLQIIVQACKEYCEQLGVDACIKLFE 717

  Fly   705 GFKSYDGLFYFLSSIVNFSQDPEVHFKYIQAACKTNQIKEVERICRESNCYNPERVKNFLKEAKL 769
            .||||:||::||.|.::.|:|||:|||||:||.||.|||||||:.||||.|:.|:.||||.||||
plant   718 QFKSYEGLYFFLGSYLSMSEDPEIHFKYIEAAAKTGQIKEVERVTRESNFYDAEKTKNFLMEAKL 782

  Fly   770 TDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVVGGLLDVDCSEDIIKNLI 834
            .|..|||.|||||.||.||..|||.||:.:|||.|||||||...|:|||.|||.:|.||.||.||
plant   783 PDARPLINVCDRFSFVPDLTHYLYTNNMLRYIEGYVQKVNPGNAPLVVGQLLDDECPEDFIKGLI 847

  Fly   835 LVVKGQFSTDELVEEVEKRNRLKLLLPWLESRVHEGCVEPATHNALAKIYIDSNNNPERYLKENQ 899
            |.|:.....:.||||.||||||:||..:||..|.||..:...||||.||.||||||||.:|..|.
plant   848 LSVRSLLPVEPLVEECEKRNRLRLLTQFLEHLVSEGSQDVHVHNALGKIIIDSNNNPEHFLTTNP 912

  Fly   900 YYDSRVVGRYCEKRDPHLACVAYERGLCDRELIAVCNENSLFKSEARYLVGRRDAELWAEVLSES 964
            ||||:|||:|||||||.||.|||.||.||.|||.|.|:|||||.:|||:|.|.|.:||.:||.|:
plant   913 YYDSKVVGKYCEKRDPTLAVVAYRRGQCDEELINVTNKNSLFKLQARYVVERMDGDLWDKVLDEN 977

  Fly   965 NPYKRQLIDQVVQTALSETQDPDDISVTVKAFMTADLPNELIELLEKIILDSSVFSDHRNLQNLL 1029
            |.|:||||||||.|||.|::.|:.:|..||||||||||:|||||||||:|.:|.||.:.||||||
plant   978 NDYRRQLIDQVVSTALPESKSPEQVSAAVKAFMTADLPHELIELLEKIVLQNSAFSGNFNLQNLL 1042

  Fly  1030 ILTAIKADRTRVMDYINRLENYDAPDIANIAISNQLYEEAFAIFKKFDVNTSAIQVLIDQVNNLE 1094
            ||||||||.:|||||||||:|:|.|.:..:|:..|||||||||||||::|..|:.||:|.|.::|
plant  1043 ILTAIKADPSRVMDYINRLDNFDGPAVGEVAVEAQLYEEAFAIFKKFNLNVQAVNVLLDNVRSIE 1107

  Fly  1095 RANEFAERCNEPAVWSQLAKAQLQQGLVKEAIDSYIKADDPSAYVDVVDVASKVESWDDLVRYLQ 1159
            ||.|||.|..|.:||||:|||||::|||.:||:|:|:|||.:.:::|:.|:...:.:||||:||.
plant  1108 RAVEFAFRVEEDSVWSQVAKAQLREGLVSDAIESFIRADDATHFLEVIRVSEDTDVYDDLVKYLL 1172

  Fly  1160 MARKKARESYIESELIYAYARTGRLADLEEFISGPNHADIQKIGNRCFSDGMYDAAKLLYNNVSN 1224
            |.|:|.:|..::||||||||:..||.::||||..||.|::|.:|:|.:.:.:|:|||::|..:||
plant  1173 MVRQKVKEPKVDSELIYAYAKIDRLGEIEEFILMPNVANLQHVGDRLYDEALYEAAKIIYAFISN 1237

  Fly  1225 FARLAITLVYLKEFQGAVDSARKANSTRTWKEVCFACVDAEEFRLAQMCGLHIVVHADELEDLIN 1289
            :.:||:|||.|::||||||:||||||.:|||||||||||||||||||:|||:|::..|:||::..
plant  1238 WGKLAVTLVKLQQFQGAVDAARKANSAKTWKEVCFACVDAEEFRLAQICGLNIIIQVDDLEEVSE 1302

  Fly  1290 YYQNRGYFDELIALLESALGLERAHMGMFTELAILYSKFKPSKMREHLELFWSRVNIPKVLRAAE 1354
            ||||||.|:|||:|:||.|||||||||:||||.:||::::..|:.||::||.:|:||||::||.:
plant  1303 YYQNRGCFNELISLMESGLGLERAHMGIFTELGVLYARYRYEKLMEHIKLFSTRLNIPKLIRACD 1367

  Fly  1355 SAHLWSELVFLYDKYEEYDNAVLAMMAHPTEAWREGHFKDIITKVANIELYYKAIEFYLDFKPLL 1419
            ....|.||.:||.:|:|:|||...:|.|..|||....||||:.||||:||||||:.|||...|.:
plant  1368 EQQHWQELTYLYIQYDEFDNAATTVMNHSPEAWEHMQFKDIVAKVANVELYYKAVHFYLQEHPDI 1432

  Fly  1420 LNDMLLVLAPRMDHTRAVSYFSKTGYLPLVKPYLRSVQSLNNKAINEALNGLLIDEEDYQGLRNS 1484
            :||:|.|||.|:||||.|....|.|:|.|:|||:.:|||.|..|:|||||.:.::||||..||.|
plant  1433 INDLLNVLALRLDHTRVVDIMRKAGHLRLIKPYMIAVQSNNVSAVNEALNEIYVEEEDYDRLRES 1497

  Fly  1485 IDGFDNFDNIALAQKLEKHELTEFRRIAAYLYKGNNRWKQSVELCKKDKLYKDAMEYAAESCKQD 1549
            ||..|:||.|.||||:|||||.|.||:|||:||...|||||:.|.|||.:|||.||.|::|.:.:
plant  1498 IDLHDSFDQIGLAQKIEKHELVEMRRVAAYIYKKAGRWKQSIALSKKDNMYKDCMETASQSGEHE 1562

  Fly  1550 IAEELLGWFLERDAYDCFAACLYQCYDLLRPDVILELAWKHKIVDFAMPYLIQVLREYTTKVDKL 1614
            :||:||.:|:|:...:|||.||:.||||:||||.|||||.:.::|||.|||:|.:|||:.|||:|
plant  1563 LAEQLLVYFIEQGKKECFATCLFVCYDLIRPDVALELAWINNMMDFAFPYLLQFIREYSGKVDEL 1627

  Fly  1615 --ELNEAQREKEDDSTEHKNII---QMEPQLMITAGPAMGIPPQYAQNYPPGAATVTAAGGRNMG 1674
              :..|||:|.:....|.|::|   .|..|::..|.||   ||.      ||     ..||...|
plant  1628 IKDKLEAQKEVKAKEQEEKDVISQQNMYAQMLPLALPA---PPM------PG-----MGGGGGYG 1678

  Fly  1675 YP 1676
            .|
plant  1679 PP 1680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Chc	NP_001096993.1	Clathrin_propel	19..56	CDD:279702	20/36 (56%)
		Clathrin_propel	148..187	CDD:279702	20/42 (48%)
		Clathrin_propel	198..234	CDD:279702	18/39 (46%)
		Clathrin_propel	256..288	CDD:279702	18/31 (58%)
		Clathrin_propel	296..330	CDD:279702	17/33 (52%)
		Clathrin-link	331..353	CDD:286367	9/21 (43%)
		Clathrin_H_link	364..422	CDD:290550	31/57 (54%)
		CLH	542..672	CDD:128594	69/129 (53%)
		Clathrin	546..679	CDD:279031	72/132 (55%)
		CLH	687..825	CDD:128594	87/137 (64%)
		Clathrin	697..827	CDD:279031	84/129 (65%)
		CLH	834..969	CDD:128594	82/134 (61%)
		Clathrin	844..971	CDD:279031	80/126 (63%)
		CLH	980..1118	CDD:128594	89/137 (65%)
		Clathrin	984..1120	CDD:279031	88/135 (65%)
		CLH	1129..1266	CDD:128594	73/136 (54%)
		Clathrin	1134..1268	CDD:279031	72/133 (54%)
		CLH	1275..1417	CDD:128594	77/141 (55%)
		Clathrin	1279..1417	CDD:279031	75/137 (55%)
		CLH	1428..1579	CDD:128594	85/150 (57%)
		Clathrin	1429..1562	CDD:279031	75/132 (57%)
AT3G08530	NP_187466.4	Clathrin_propel	20..56	CDD:396117	20/36 (56%)
		Clathrin_propel	154..197	CDD:396117	20/42 (48%)
		Clathrin_propel	266..301	CDD:396117	20/34 (59%)
		Clathrin-link	344..367	CDD:401271	10/22 (45%)
		Clathrin_H_link	369..434	CDD:404683	37/65 (57%)
		CLH	552..688	CDD:128594	71/136 (52%)
		CLH	701..838	CDD:128594	87/136 (64%)
		CLH	847..982	CDD:128594	82/134 (61%)
		CLH	993..1132	CDD:128594	90/138 (65%)
		CLH	1142..1279	CDD:128594	73/136 (54%)
		CLH	1288..1430	CDD:128594	77/141 (55%)
		Clathrin	1437..1575	CDD:395512	79/137 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	185	1.000	Domainoid score	I1000
eggNOG	1	0.900	-	-		E1_KOG0985
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3572
Inparanoid	1	1.050	1765	1.000	Inparanoid score	I5
OMA	1	1.010	-	-		QHG53703
OrthoDB	1	1.010	-	-		D17940at2759
OrthoFinder	1	1.000	-	-		FOG0002324
OrthoInspector	1	1.000	-	-		otm3142
orthoMCL	1	0.900	-	-		OOG6_101144
Panther	1	1.100	-	-	O	PTHR10292
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1532
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840